Neuro-Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 7, 2024
Supratotal-Resection (SpTR) is a promising surgical strategy in Lower-grade gliomas (LGGs). SpTR assessment, feasibility and distinctive features, as well clinical benefit at first second surgery on overall-survival must be better characterized. The critical percentage of resection exceeding FLAIR margins to obtain its impact long-term functional performance are also undefined.
Language: Английский
Molecular Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: April 3, 2024
In recent years, the discovery of functional and communicative cellular tumour networks has led to a new understanding malignant primary brain tumours. this review, authors shed light on diverse nature cell‐to‐cell connections in tumours propose an innovative treatment approach address detrimental connectivity these networks. The proposed therapeutic outlook revolves around three main strategies: (a) supramarginal resection removing substantial portion communicating cell front far beyond gadolinium‐enhancing mass, (b) morphological isolation at single level disrupting structural contacts facilitated by elongated membrane protrusions known as microtubes (TMs), (c) blocking TM‐mediated intercellular cytosolic exchange inhibiting neuronal excitatory input into network. We draw analogy between Alcatraz Federal Penitentiary, where inmates faced impassable sea barrier experienced both spatial within individual cells. Based current translational efforts ongoing clinical trials, we Alcatraz‐Strategy promising framework tackle harmful effects
Language: Английский
Citations
7
Current Neurology and Neuroscience Reports, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 9, 2025
Language: Английский
Citations
0
CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(4)
Published: April 1, 2025
The current study aimed to investigate brain network abnormalities in glioma-related epilepsy (gre) patients through high-density electroencephalography (eeg) data analysis. included 35 with newly diagnosed frontal gliomas. All participants underwent 128-channel resting-state EEG recordings before surgery. Afterward, graph theory and microstate analyses were performed, the resulting metrics compared between GRE those without GRE. topology analysis demonstrated that group had a higher clustering coefficient, global efficiency, local efficiency; lower characteristic path length; small-worldness coefficient than non-GRE (adjusted p < 0.05 for all). Additionally, indicated occurrence explained variance of E D Moreover, was significantly negatively correlated maximum tumor diameter (r = -0.542, 0.009). revealed specific based on data. These findings can enhance our comprehension mechanisms behind offer potential biomarkers improving individualized management glioma patients.
Language: Английский
Citations
0
Acta Neurochirurgica, Journal Year: 2024, Volume and Issue: 166(1)
Published: Oct. 28, 2024
Language: Английский
Citations
1
Neuro-Oncology, Journal Year: 2023, Volume and Issue: 26(3), P. 528 - 537
Published: Oct. 31, 2023
Abstract Background Patients with low-grade gliomas (LGG) treated surgery, generally function well and have a favorable prognosis. However, LGG can affect neurocognitive functioning. To date, little is known about social cognition (SC) in these patients, although impaired SC related to social-behavioral problems poor societal participation. Frontal brain areas are important for frequently frontal location. Therefore, the aim of present study was investigate whether emotion recognition, key component SC, impaired, general cognition, tumor location, laterality, volume, histopathological characteristics patients LGG, postsurgery, before start adjuvant therapy. Methods A total 121 were matched 169 healthy controls (HC). Tumor location [including (frontal) subregions; insula, anterior cingulate cortex, lateral prefrontal cortex (LPFC), orbitofrontal-ventromedial PFC] volume determined on MRI scans. Emotion recognition measured Ekman 60 faces test Facial Expressions Emotion-Stimuli Tests (FEEST). Results performed significantly lower FEEST than HC, 33.1% showing impairment compared norm data. not correlated characteristics, but weakly volume. Conclusions (strongly) specific or cognition. Hence, measuring individual neuropsychological assessment crucial, irrespective inform clinicians possible impairments, consequently offer appropriate care.
Language: Английский
Citations
3
Bulletin de l Académie Nationale de Médecine, Journal Year: 2024, Volume and Issue: 208(6), P. 824 - 831
Published: April 26, 2024
Citations
0
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(9), P. 887 - 887
Published: Aug. 30, 2024
Incidentally discovered low-grade gliomas (iLGGs) are very rare and little is still known about their associated functional imaging activation patterns, white-matter status, plasticity potential. Recent studies shed light on several clinical factors responsible for the good status observed in these patients versus those with symptomatic counterpart (sLGGs), including small volume. Comparisons were typically carried out by comparing iLGGs wider more heterogeneous sLGG group. In this study, we investigated whether affect brain differently from comparably sLGGs.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0
Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 337 - 350
Published: Jan. 1, 2024
Language: Английский
Citations
0
Neuro-Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 7, 2024
Supratotal-Resection (SpTR) is a promising surgical strategy in Lower-grade gliomas (LGGs). SpTR assessment, feasibility and distinctive features, as well clinical benefit at first second surgery on overall-survival must be better characterized. The critical percentage of resection exceeding FLAIR margins to obtain its impact long-term functional performance are also undefined.
Language: Английский
Citations
0