Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 3, 2024
Abstract
Proton
therapy
is
an
advanced
radiation
technique
that
allows
for
precise
treatment
of
the
tumor
site.
3D
water
phantom
system
important
testing
equipment
proton
therapy,which
can
guarantee
dose
before
treatment,
realize
distribution
scanning
detection.
It
includes
a
lifting
platform,
high-precision
three-dimensional
servo,
ionization
chambers,
control
and
tank.
The
platform
servo
are
key
factors
which
affect
accuracy
beam
measurement.
structure
design
carried
out
to
Finite
element
analysis
model
established
carry
mechanical
mechanics
structure.
During
detection,
vibration
generated
by
motor
operation
may
cause
resonance,
modal
harmonic
response
analysis,
calculate
intrinsic
frequency
within
possible
resonance
intervals.
In
addition,
was
utilized
Bragg
peak
detection
experiments
at
different
energies
therapy.
International Journal of Scientific Research in Science and Technology,
Journal Year:
2025,
Volume and Issue:
12(1), P. 126 - 131
Published: Jan. 20, 2025
Delivering
an
accurate
dose
to
the
target
in
radiotherapy
is
crucial
for
maximizing
effectiveness
of
prostate
cancer
treatment
while
minimizing
side
effects.
Proton
therapy
offers
significant
potential
advantages
over
conventional
due
its
unique
physical
properties,
particularly
ability
precisely
deposit
energy
at
a
specific
depth
using
Spread-Out
Bragg
Peak
(SOBP)
technique.
The
SOBP
ensures
uniform
distribution
across
tumor,
sparing
surrounding
healthy
tissues.
However,
challenges
remain
designing
optimal
that
achieves
precise
delivery,
especially
given
complex
interplay
proton
energies
and
depths.
This
study
addresses
these
by
utilizing
Geant4
simulations
model
generation
through
use
multiple
pencil
beam
energies.
Additionally,
MATLAB
Linear
Least
Squares
(lsqlin)
optimization
tool
was
employed
determine
weighting
configurations
achieving
desired
distributions.
results
demonstrate
optimized
can
be
successfully
achieved,
offering
promising
foundation
enhancing
treatment.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(18), P. 4560 - 4560
Published: Sept. 14, 2023
Bragg
peak
FLASH-RT
can
deliver
highly
conformal
treatment
and
potentially
offer
improved
normal
tissue
protection
for
radiotherapy
patients.
This
study
focused
on
developing
ultra-high
dose
rate
(≥40
Gy
×
RBE/s)
intensity-modulated
proton
therapy
(IMPT)
hypofractionated
of
early-stage
breast
cancer.
A
novel
tracking
technique
was
developed
to
enable
pencil
beaming
scanning
(PBS)
single-energy
protons
adapt
the
(BP)
target
distally.
Standard-of-care
PBS
plans
consecutively
treated
cancer
patients
using
multiple
energy
layers
were
reoptimized
this
technique,
metrics
compared
between
layer
BP
FLASH
conventional
IMPT
plans.
coverage
by
volume
(V40Gy/s)
also
evaluated
sparing
effect.
Distal
precisely
stop
at
distal
edge.
All
(n
=
10)
achieved
IMPT-like
distributions
under
clinical
machine
parameters.
No
statistically
significant
differences
observed
in
any
heart,
ipsilateral
lung,
most
breast,
CTV
(p
>
0.05
all).
Conventional
yielded
slightly
superior
skin
uniformities
with
4.5%
12.9%
lower
maxes,
respectively.
reached
46.7%
61.9%
average-dose
tissues
receiving
more
than
1
5
plan
total
250
minimum
MU
condition.
techniques
comparable
quality
while
reaching
adequate
ratios,
demonstrating
feasibility
applications.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(4), P. 798 - 798
Published: Feb. 15, 2024
Bragg
peak
FLASH
radiotherapy
(RT)
uses
a
distal
tracking
method
to
eliminate
exit
doses
and
can
achieve
superior
OAR
sparing.
This
study
explores
the
application
of
this
novel
in
stereotactic
body
prostate
FLASH-RT.
An
in-house
platform
was
developed
enable
intensity-modulated
proton
therapy
(IMPT)
planning
using
single-energy
method.
The
patients
involved
were
previously
treated
with
(SBRT)
pencil
beam
scanning
(PBS)
technique
40
Gy
five
fractions.
plans
optimized
four-beam
arrangement
generate
dose
distribution
similar
conventional
opposing
beams.
All
beams
had
small
angle
two
degrees
from
lateral
direction
increase
dosimetry
quality.
Dose
metrics
compared
between
PBS
plans.
rate
histogram
(DRVH)
Gy/s
coverage
(V40Gy/s)
investigated
for
There
no
significant
difference
clinical
rectum,
bladder,
femur
heads,
large
bowel,
penile
bulb
metrics,
except
Dmax.
For
CTV,
resulted
higher
Dmax
than
(116.9%
vs.
103.3%).
V40Gy/s
reached
94%
93%
1
thresholds
composite
single-field
evaluations,
respectively.
Additionally,
ratio
close
100%
after
5
threshold
assessment.
In
conclusion,
yield
comparable
plan
quality
most
OARs
while
preserving
sufficient
coverage,
demonstrating
that
ultra-high
be
applied
SBRT.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(19), P. 3249 - 3249
Published: Sept. 24, 2024
Ultrahigh-dose-rate
therapy,
also
known
as
FLASH
radiotherapy
(RT),
is
an
emerging
technique
that
garnering
significant
interest
in
cancer
treatment
due
to
its
potential
revolutionize
therapy.
This
method
can
achieve
comparable
tumor
control
conventional-dose-rate
RT
while
offering
the
enhanced
protection
of
normal
tissue
through
FLASH-sparing
effect.
innovative
has
demonstrated
promising
results
preclinical
studies
involving
animals
and
cell
lines.
Particularly
noteworthy
application
treating
head
neck
(HN)
cancers,
especially
patients
with
challenging
recurrent
tumors
reirradiation
cases,
where
toxicity
rates
conventional
are
high.
Such
applications
aim
enhance
minimizing
side
effects
preserving
patients’
quality
life.
In
comparison
electron
or
photon
modalities,
proton
therapy
superior
dosimetric
delivery
characteristics
a
safe
effective
for
human
malignancies.
Compared
transmission
FLASH,
single-energy
Bragg
peak
novel
allows
highly
conformal
doses
targets
minimal
radiation
crucial
OARs.
Proton
HN
still
not
been
well
studied.
review
highlights
significance
enhancing
by
examining
advantages
challenges
using
it
reirradiation.
Clinical and Translational Radiation Oncology,
Journal Year:
2023,
Volume and Issue:
45, P. 100712 - 100712
Published: Dec. 9, 2023
This
study
explores
the
effects
of
UHDR
irradiation
on
Caenorhabditis
elegans
embryos.
proton
and
electron
beams
demonstrate
a
sparing
effect,
aligning
with
literature
findings.
highlights
C.
suitability
as
screening
model
for
studying
LET
impact
FLASH
reinforcing
its
potential
in
radiation
research.
