Structural Design, Analysis and Testing of 3D Water Phantom for Proton Therapy DOI Creative Commons
Xinzhi Liu,

Kaisong Wang,

Jianghua Wei

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Proton therapy is an advanced radiation technique that allows for precise treatment of the tumor site. 3D water phantom system important testing equipment proton therapy,which can guarantee dose before treatment, realize distribution scanning detection. It includes a lifting platform, high-precision three-dimensional servo, ionization chambers, control and tank. The platform servo are key factors which affect accuracy beam measurement. structure design carried out to Finite element analysis model established carry mechanical mechanics structure. During detection, vibration generated by motor operation may cause resonance, modal harmonic response analysis, calculate intrinsic frequency within possible resonance intervals. In addition, was utilized Bragg peak detection experiments at different energies therapy.

Language: Английский

Navigating the straits: realizing the potential of proton FLASH through physics advances and further pre-clinical characterization DOI Creative Commons
John D. Fenwick, Christopher N. Mayhew, S. Jolly

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: July 3, 2024

Ultra-high dose-rate ‘FLASH’ radiotherapy may be a pivotal step forward for cancer treatment, widening the therapeutic window between radiation tumour killing and damage to neighbouring normal tissues. The extent of tissue sparing reported in pre-clinical FLASH studies typically corresponds an increase isotoxic dose-levels 5–20%, though gains are larger at higher doses. Conditions currently thought necessary ≥40 Gy s -1 , dose-per-fraction ≥5–10 irradiation duration ≤0.2–0.5 s. Cyclotron proton accelerators first clinical systems adapted irradiate deep-seated tumours dose-rates, but even using these machines it is challenging meet conditions. In this review we describe challenges delivering beam therapy, compromises that ensue if not addressed, resulting dosimetric losses. Some losses on same scale as from found pre-clinically. We therefore conclude succeed clinically must systematically overcome rather than accommodated, survey physical routes achieving this.

Language: Английский

Citations

1
Combined optimization of spot positions and weights for better FLASH proton therapy DOI
P. Lansonneur,

Anthony Magliari,

Luigi Rosa

et al.

Physics in Medicine and Biology, Journal Year: 2024, Volume and Issue: 69(12), P. 125010 - 125010

Published: May 15, 2024

In Intensity Modulated Proton Therapy (IMPT), the weights of individual pencil-beams or spots are optimized to fulfil dosimetric constraints. Theses usually located on a regular lattice and their positions fixed during optimization. many cases, range spot may however be limited, leading sometimes sub-optimal plan quality. An emblematic use case is delivery at ultra-high dose rate (FLASH-RT), for which typically constrained high values.

Language: Английский

Citations

0
Technical note: Dosimetry and FLASH potential of UHDR proton PBS for small lung tumors: Bragg‐peak‐based delivery versus transmission beam and IMPT DOI Creative Commons

Patricia van Marlen,

Steven van de Water,

Ben J. Slotman

et al.

Medical Physics, Journal Year: 2024, Volume and Issue: 51(10), P. 7580 - 7588

Published: May 25, 2024

High-energy transmission beams (TBs) are currently the main delivery method for proton pencil beam scanning ultrahigh dose-rate (UHDR) FLASH radiotherapy. TBs place Bragg-peaks behind target, outside patient, making practical and achievement of high dose-rates more likely. However, they lead to higher integral dose compared conventional intensity-modulated therapy (IMPT), in which placed within tumor. It is hypothesized that, when energy changes not required currents possible, Bragg-peak-based can only achieve conformal distributions than TBs, but also have FLASH-potential.

Language: Английский

Citations

0
A multidisciplinary view of FLASH irradiation DOI

Flavia Gesualdi,

Ludovic De Marzi, Marie Dutreix

et al.

Cancer/Radiothérapie, Journal Year: 2024, Volume and Issue: 28(5), P. 453 - 462

Published: Sept. 28, 2024

Language: Английский

Citations

0
FLASH Radiotherapy: Benefits, Mechanisms, and Obstacles to Its Clinical Application DOI Open Access

Lina Alhaddad,

А. Н. Осипов, Sergey Leonov

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12506 - 12506

Published: Nov. 21, 2024

Radiotherapy (RT) has been shown to be a cornerstone of both palliative and curative tumor care. RT generally reported sharply limited by ionizing radiation (IR)-induced toxicity, thereby constraining the control effect on growth. FLASH-RT is delivery ultra-high dose rate (UHDR) several orders magnitude higher than what presently used in conventional (CONV-RT). The clinical trials have designed examine UHDR deliverability, effectiveness control, tolerance normal tissue, reproducibility treatment effects across institutions. Although it still its infancy, potential rival current terms safety. Several studies suggested that adoption very limited, incorporation this new technique into routine will require use accurate dosimetry methods reproducible equipment enable reliable robust measurements doses rates. purpose review highlight advantages technology, mechanisms underpinning effect, major challenges need tackled transfer FLASH-RT.

Language: Английский

Citations

0
Structural Design, Analysis and Testing of 3D Water Phantom for Proton Therapy DOI Creative Commons
Xinzhi Liu,

Kaisong Wang,

Jianghua Wei

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Proton therapy is an advanced radiation technique that allows for precise treatment of the tumor site. 3D water phantom system important testing equipment proton therapy,which can guarantee dose before treatment, realize distribution scanning detection. It includes a lifting platform, high-precision three-dimensional servo, ionization chambers, control and tank. The platform servo are key factors which affect accuracy beam measurement. structure design carried out to Finite element analysis model established carry mechanical mechanics structure. During detection, vibration generated by motor operation may cause resonance, modal harmonic response analysis, calculate intrinsic frequency within possible resonance intervals. In addition, was utilized Bragg peak detection experiments at different energies therapy.

Language: Английский

Citations

0