Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy – Significance for cancer treatment?
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2024,
Volume and Issue:
1879(4), P. 189124 - 189124
Published: May 25, 2024
Apoptosis
has
traditionally
been
regarded
as
the
desired
cell
death
pathway
activated
by
chemotherapeutic
drugs
due
to
its
controlled
and
non-inflammatory
nature.
However,
recent
discoveries
of
alternative
pathways
have
paved
way
for
immune-stimulatory
treatment
approaches
in
cancer.
Ferroptosis
(dependent
on
iron)
cuproptosis
copper)
hold
promise
selective
cancer
targeting
overcoming
drug
resistance.
Copper
ionophores
iron-bearing
nano-drugs
show
potential
clinical
therapy
single
agents
adjuvant
treatments.
Here
we
review
up-to-date
evidence
involvement
metal
ion-dependent
cytotoxicity
classical
(alkylating
agents,
topoisomerase
inhibitors,
antimetabolites,
mitotic
spindle
inhibitors)
their
combinations
with
ferroptosis
inducers,
indicating
prospects,
advantages,
obstacles
use.
Language: Английский
NINJ1 in Cell Death and Ferroptosis: Implications for Tumor Invasion and Metastasis
Ssu-Yu Chen,
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Ing-Luen Shyu,
No information about this author
Jen‐Tsan Chi
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et al.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(5), P. 800 - 800
Published: Feb. 26, 2025
NINJ1
was
initially
recognized
for
its
role
in
nerve
regeneration
and
cellular
adhesion.
Subsequent
studies
have
uncovered
participation
cancer
progression,
where
regulates
critical
steps
tumor
metastasis,
such
as
cell
migration
invasion.
More
recently,
has
emerged
a
multifunctional
protein
mediating
plasma
membrane
rupture
(PMR)
several
lytic
death
processes,
including
apoptosis,
necroptosis,
pyroptosis.
However,
ferroptosis-an
iron-dependent
form
of
characterized
by
lipid
peroxidation-remained
unclear
until
2024.
Ferroptosis
is
suppression
mechanism
that
may
be
particularly
relevant
to
detached
metastatic
cells.
This
review
explores
the
invasion
focusing
on
regulation
ferroptosis
via
non-canonical
distinct
from
other
deaths.
We
discuss
process
implications
metastasis.
Furthermore,
we
recent
highlighting
diverse
roles
regulation,
canonical
function
PMR
modulating
intracellular
levels
glutathione
(GSH)
coenzyme
A
(CoA)
interaction
with
xCT
anti-porter.
Given
been
associated
suppression,
elimination
treatment-resistant
cells,
dormancy,
NINJ1's
modulation
presents
promising
therapeutic
target
inhibiting
Understanding
dual
promoting
or
restraining
depending
context
could
open
avenues
novel
anti-cancer
strategies
enhance
ferroptotic
vulnerability
tumors.
Language: Английский
Nanomaterial‐Triggered Ferroptosis and Cuproptosis in Cancer Therapy
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Abstract
Cancer
remains
one
of
the
leading
causes
death
individuals
globally.
Conventional
treatment
techniques
like
chemotherapy
and
radiation
often
suffer
various
drawbacks
toxicity
drug
resistance.
The
study
cell
has
been
predominantly
focused
on
classical
forms
apoptosis,
but
role
metal
ions
in
governing
controlled
is
a
fascinating
less
explored
area.
Metal‐mediated
process
where
triggers
via
unique
mechanism.
Nanomaterial‐based
strategies
have
gained
attention
for
their
ability
to
deliver
precise
therapeutic
agents
while
also
triggering
Regulated
Cell
Death
(RCD)
mechanisms
cancer
cells.
recently
discovered
metal‐mediated
cuproptosis
ferroptosis
can
be
used
as
they
selectively
drug‐resistant
cancer.
Nano
material‐based
delivery
system
targeted
sites.
In
this
review,
we
given
some
idea
about
mechanism
(ferroptosis
cuproptosis)
how
initiate
deaths
using
nanomaterials
treatment.
Language: Английский