Epigenetic Regulation of Acute Lymphoblastic Leukemia
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Advances in Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
15(01), P. 642 - 651
Published: Jan. 1, 2025
Language: Английский
Eph/ephrin-mediated immune modulation: a potential therapeutic target
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 22, 2025
Eph/ephrin
signaling,
a
complex
network
of
cell-cell
interactions,
plays
pivotal
role
in
regulating
various
biological
processes,
including
cell
migration,
proliferation,
and
adhesion.
Dysregulation
this
signaling
pathway
has
been
implicated
types
cancer.
In
skin
cancers
such
as
squamous
carcinoma,
basal
malignant
melanoma,
promotes
tumor
invasion
metastasis.
Aberrant
expression
Eph
receptors
ephrin
ligands
can
lead
to
increased
motility,
reduced
adhesion,
enhanced
angiogenesis.
Furthermore,
significantly
impact
the
microenvironment
by
modulating
infiltration
activation
immune
cells,
particularly
T
cells.
Dysregulated
impair
surveillance
mechanisms,
leading
evasion
progression.
For
instance,
certain
inhibit
T-cell
promote
immunosuppressive
conditions
within
microenvironment.
Targeting
offers
promising
therapeutic
approach
combating
cancer
By
disrupting
these
pathways,
invasion,
angiogenesis,
be
inhibited.
This
could
improved
outcomes
for
patients
with
Language: Английский
The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3834 - 3834
Published: March 29, 2024
Pediatric
neoplasms
represent
a
complex
group
of
malignancies
that
pose
unique
challenges
in
terms
diagnosis,
treatment,
and
understanding
the
underlying
molecular
pathogenetic
mechanisms.
Erythropoietin-producing
hepatocellular
receptors
(EPHs),
largest
family
receptor
tyrosine
kinases
their
membrane-tethered
ligands,
ephrins,
orchestrate
short-distance
cell–cell
signaling
are
intricately
involved
cell-pattern
morphogenesis
various
developmental
processes.
Unraveling
role
EPH/ephrin
pathway
pathophysiology
pediatric
its
clinical
implications
can
contribute
to
deciphering
intricate
landscape
these
malignancies.
The
bidirectional
nature
axis
is
underscored
by
emerging
evidence
revealing
capacity
drive
tumorigenesis,
fostering
communication
within
tumor
microenvironment.
In
context
carcinogenesis,
prompts
reevaluation
treatment
strategies,
particularly
oncology,
where
modest
progress
survival
rates
enduring
toxicity
necessitate
novel
approaches.
Molecularly
targeted
agents
have
emerged
as
promising
alternatives,
prompting
shift
focus.
Through
nuanced
pathway’s
intricacies,
we
aim
lay
groundwork
for
personalized
diagnostic
therapeutic
ultimately
contributing
improved
outcomes
young
patients
grappling
with
neoplastic
challenges.
Language: Английский
Association of the rs1966265 and rs351855 FGFR4 Variants with Colorectal Cancer in a Mexican Population and Their Analysis In Silico
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(3), P. 602 - 602
Published: March 7, 2024
The
aim
of
this
study
was
to
associate
FGFR4
rs1966265
and
rs351855
variants
with
colorectal
cancer
(CRC)
in
a
Mexican
population
perform
silico
analysis.
Genomic
DNA
from
412
healthy
individuals
475
CRC
patients
analyzed.
In
analysis
performed
using
the
PolyPhen-V2,
GEPIA,
GTEx,
Cytoscape
platforms.
GA
genotype
dominant
model
(GAAA)
AA
recessive
models
were
identified
as
risk
factors
(p
<
0.05).
aged
≥
50
years
at
diagnosis
who
consumed
alcohol
had
higher
incidence
than
control
group
Associations
observed
between
rectal
stage
III–IV
disease.
factor
for
partial
chemotherapy
response,
+
age
associated
response
haplotype
increased
susceptibility
CRC.
indicated
that
variant
is
likely
pathogenic
(score
=
0.998).
Genotypic
expression
blood
samples
showed
statistically
significant
differences
EFNA4,
SLC3A2,
HNF1A
share
signaling
pathways
FGFR4.
Therefore,
may
be
potential
factors.
Language: Английский