Arhiv za farmaciju, Journal Year: 2024, Volume and Issue: 74(3), P. 375 - 390
Published: Jan. 1, 2024
Obesity represents a serious medical condition and has nowadays reached pandemic proportions. Comorbidities associated with obesity are severe, affect almost all organ systems. Adipose tissue several important functions: to provide energy storage, maintain body temperature through the process of thermogenesis, balance in variety metabolic patterns. is an endocrine numerous biochemical roles, obese individuals adipose becomes either hypertrophic or hyperplastic, impaired function. The immune system activity regulation extremely related processes. A loss on this axis causes disorders obesity, basis these insulin resistance, which hallmark obesity. Hormones that exclusively produced adipocytes studied various biochemistry processes leptin, adiponectin resistin. Successful treatment involves lifestyle diet modification, pharmacotherapy, mainly glucagon-like peptide-1 agonists, bariatric surgery, remains most effective method for selected population severely individuals. Positive effects surgery reflected not only restriction food intake, but hormonal changes, especially those gut hormones responsible hunger metabolism.
Language: Английский