Interplay of RNA m6A Modification-Related Geneset in Pan-Cancer

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2211 - 2211

Published: Sept. 27, 2024

: N

Language: Английский

Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 3031 - 3031

Published: Aug. 30, 2024

Background: mTORC1 activity is dependent on the presence of micronutrients, including Asparagine (Asn), to promote anabolic cell signaling in many cancers. We hypothesized that targeting Asn metabolism would inhibit tumor growth by reducing well-differentiated (WD)/dedifferentiated (DD) liposarcoma (LPS). Methods: Human metabolomic analysis was utilized compare abundance WD vs. DD LPS. Gene set enrichment (GSEA) compared relative expression among metabolic pathways upregulated Proliferation assays were performed for LPS lines and organoid models using combination treatment electron transport chain (ETC) inhibitors with Asn-free media. 13C-Glucose-labeling metabolomics evaluated effects nucleotide synthesis. Murine xenograft used assess ETC inhibition combined PEGylated L-Asparaginase (PEG-Asnase) signaling. Results: enriched GSEA indicated Within available models, media resulted reduced proliferation. Combination inhibited synthesis promoted cycle arrest. In vivo, PEG-Asnase restricted growth. Conclusions: upregulation are important factors contributing WD/DD progression. Effective strategies require limiting access extracellular de novo mechanisms. The an effective therapy restrict

Language: Английский

Integrated lipidomics and RNA-seq reveal prognostic biomarkers in well-differentiated and dedifferentiated retroperitoneal liposarcoma

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

Language: Английский