Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2363 - 2363
Published: Oct. 16, 2024
Neurosurgery
demands
exceptional
precision
due
to
the
brain's
complex
and
delicate
structures,
necessitating
precise
targeting
of
pathological
targets.
Achieving
optimal
outcomes
depends
on
surgeon's
ability
accurately
differentiate
between
healthy
tissues
during
operations.
Raman
spectroscopy
(RS)
has
emerged
as
a
promising
innovation,
offering
real-time,
in
vivo
non-invasive
biochemical
tissue
characterization.
This
literature
review
evaluates
current
research
RS
applications
intraoperative
neurosurgery,
emphasizing
its
potential
enhance
surgical
patient
outcomes.
World Neurosurgery,
Journal Year:
2024,
Volume and Issue:
185, P. e612 - e619
Published: Feb. 28, 2024
Meningiomas
show
variable
tendency
to
recur.
While
risk
factors
of
recurrence
have
been
largely
investigated
in
literature,
paucity
data
are
available
on
the
time
recurrence.
To
identify
main
affecting
assist
preoperative
treatment
decision-making
strategy
and
define
a
tailored
clinical
neuroradiological
follow-up.
Data
35
patients
with
intracranial
meningioma
recurrences
retrospectively
reviewed.
Demographic
(patient
age
at
initial
diagnosis
sex),
radiological
(meningioma
location,
pattern
regrowth
topography
first
reoperation),
pathological
(WHO
grade
Ki67-MIB1
surgery
reoperation,
progesterone
receptor
(PR)
expression),
surgical
(extent
resection
according
Simpsons
grading
system,
number
reoperations)
were
analyzed.
Time
ranged
from
20
120
months.
Extent
was
Simpson
I
7
(20%),
II
10
(28.5%),
III
14
(40%)
IV
4
(11.5%).
Longer
median
observed
for
skull
base
localization
(p<0.01),
grades
versus
(p=0.01)
(p=0.02),
values
Ki67-MIB1≤
4%
(p=0.001)
PR>60%
(p=0.03);
conversely,
sex
age,
reoperations
unchanged/progression
Ki67
and/or
WHO
between
reoperation
did
not
correlate
statistically
significant
way
The
extent
represent
most
important
predicting
shorter
meningiomas.
Patients
incomplete
(Simpson
IV)
high
values,
especially
non-skull
low
PR
need
closer
short-term
follow-up
years
after
surgery.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 5, 2025
Photoacoustic
brain
imaging
(PABI)
has
emerged
as
a
promising
biomedical
modality,
combining
high
contrast
of
optical
with
deep
tissue
penetration
ultrasound
imaging.
This
review
explores
the
application
photoacoustic
in
tumor
imaging,
highlighting
synergy
between
nanomaterials
and
state
art
techniques
to
achieve
high-resolution
deeper
tissues.
PABI
leverages
effect,
where
absorbed
light
energy
causes
thermoelastic
expansion,
generating
waves
that
are
detected
converted
into
images.
technique
enables
precise
diagnosis,
therapy
monitoring,
enhanced
clinical
screening,
specifically
management
complex
diseases
such
breast
cancer,
lymphatic
disorder,
neurological
conditions.
Despite
integration
agents
radiation,
providing
comprehensive
overview
current
methodologies,
major
obstacles
treatment,
future
directions
for
improving
diagnostic
therapeutic
outcomes.
The
underscores
significance
robust
research
tool
medical
method,
potential
revolutionize
disease
diagnosis
treatment.
npj Imaging,
Journal Year:
2025,
Volume and Issue:
3(1)
Published: Jan. 24, 2025
Abstract
Molecular
imaging
is
used
in
clinical
and
research
settings.
Since
tools
to
study
viral
pathogenesis
longitudinally
systemically
are
limited,
molecular
an
attractive
largely
unexplored
tool.
This
review
discusses
probes
techniques
for
studying
viruses,
particularly
those
currently
oncology
that
applicable
virology.
Expanding
the
repertoire
of
better
detect
disease
may
make
even
more
valuable
(pre-)clinical
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(10), P. 4554 - 4554
Published: May 9, 2025
Currently,
the
focus
of
intraoperative
imaging
in
brain
tumor
surgery
is
beginning
to
shift
optical
methods
such
as
coherence
tomography
(OCT),
Raman
spectroscopy,
confocal
laser
endomicroscopy
(CLE),
and
fluorescence
lifetime
(FLIM).
Optical
technologies
provide
vivo
real-time
high-resolution
images
tissues.
“Optical
biopsy”
can
be
considered
an
alternative
traditional
approaches
for
histopathologic
consultation.
Intraoperative
help
achieve
precise
identification
infiltrations
within
surrounding
parenchyma.
Therefore,
it
a
complement
existing
based
on
wide-field
modalities
MRI,
US,
or
5-ALA
fluorescence.
A
promising
future
direction
guidance
during
stereotactic
biopsy
lies
integration
with
machine
learning
techniques,
enabling
automated
differentiation
between
tissue
healthy
We
present
this
review
increase
knowledge
form
critical
opinions
field
using
surgery.
Photonics,
Journal Year:
2024,
Volume and Issue:
11(5), P. 435 - 435
Published: May 8, 2024
Brain
tumors
arise
from
abnormal
cell
growth
in
the
brain.
Glioblastoma,
most
common
and
aggressive
type,
poses
significant
challenges
for
identification
during
surgery.
The
primary
goal
of
this
study
is
to
identify
differentiate
normal
brain
tissue
glioblastoma
using
optical
coherence
tomography
(OCT)
OCT
angiography
(OCTA).
These
techniques
offer
a
non-invasive
way
analyze
morphological
microvascular
alternations
associated
with
an
animal
model.
To
monitor
changes
morphology
vascular
distribution
as
grow,
time-series
OCTA
results
were
collected
comparison.
Texture
analysis
images
was
proposed
gray-level
co-occurrence
matrix
(GLCM),
which
homogeneity
variance
calculated
discriminative
parameters.
Additionally,
used
assess
characteristics,
including
vessel
diameter,
density,
fractal
dimension.
findings
demonstrate
that
methods
can
effectively
distinguish
between
cancerous
vivo.
Abstract
Background
Gliomas,
particularly
glioblastoma
multiforme
(GBM),
are
highly
aggressive
brain
tumors
that
present
significant
challenges
in
oncology
due
to
their
rapid
progression
and
resistance
conventional
therapies.
Despite
advancements
treatment,
the
prognosis
for
patients
with
GBM
remains
poor,
necessitating
exploration
of
novel
therapeutic
approaches.
One
such
emerging
strategy
is
development
glioma
vaccines,
which
aim
stimulate
immune
system
target
destroy
tumor
cells.
Aims
This
review
aims
provide
a
comprehensive
evaluation
current
landscape
vaccine
development,
analyzing
types
vaccines
under
investigation,
outcomes
clinical
trials,
opportunities
associated
implementation.
The
goal
highlight
potential
advancing
more
effective
personalized
treatments
patients.
Materials
Methods
narrative
systematically
assessed
role
by
including
full‐text
articles
published
between
2000
2024
English.
Databases
as
PubMed/MEDLINE,
EMBASE,
Cochrane
Library,
Scopus
were
searched
using
key
terms
like
“glioma,”
“brain
tumor,”
“glioblastoma,”
“vaccine,”
“immunotherapy.”
incorporated
both
pre‐clinical
studies,
descriptive
animal‐model
cohort
observational
studies.
Exclusion
criteria
applied
omit
abstracts,
case
reports,
posters,
non‐peer‐reviewed
ensuring
inclusion
high‐quality
evidence.
Results
Clinical
trials
investigating
various
peptide‐based,
DNA/RNA‐based,
whole‐cell,
dendritic‐cell
have
shown
promising
results.
These
demonstrated
extending
survival
rates
managing
adverse
events
However,
remain,
heterogeneity
evasion
mechanisms.
Moreover,
lack
standardized
guidelines
evaluating
responses
issues
related
ethical
considerations,
regulatory
hurdles,
acceptance
among
further
complicate
implementation
vaccines.
Discussion
Addressing
involves
exploring
combination
therapies,
targeted
approaches,
medicine.
Combining
traditional
therapies
radiotherapy
or
chemotherapy
may
enhance
efficacy
boosting
system’s
ability
fight
Personalized
tailored
individual
patient
profiles
an
opportunity
improved
outcomes.
Furthermore,
global
collaboration
equitable
distribution
critical
access
especially
low‐
middle‐income
countries
limited
healthcare
resources
Conclusion
Glioma
represent
avenue
against
gliomas,
offering
hope
improving
disease
notoriously
difficult
treat.
challenges,
continued
research
innovative
strategies,
essential
overcoming
barriers
transforming
treatment
Brain and Spine,
Journal Year:
2024,
Volume and Issue:
4, P. 102794 - 102794
Published: Jan. 1, 2024
The
field
of
neurosurgery
faces
challenges
with
the
increasing
involvement
other
medical
specialties
in
areas
traditionally
led
by
neurosurgeons.
This
paper
examines
implications
this
development
for
neurosurgical
practice
and
patient
care,
a
focus
on
specialized
like
pain
management,
peripheral
nerve
surgery,
stereotactic
radiosurgery.
To
assess
expanded
scope
to
consider
response
EANS
Frontiers
Neurosurgery
Committee
these
challenges.
Analysis
recent
trends
neurosurgery,
including
shift
various
procedures
specialties,
demographic
challenges,
emergence
minimally
invasive
techniques.
analysis
draws
relevant
literature
initiatives
Committee.
We
explore
possible
decrease
certain
areas,
which
may
have
care
access
interventions.
Committee's
role
addressing
concerns
is
highlighted,
particularly
terms
training,
education,
research,
networking
neurosurgeons,
especially
those
early
their
careers.
potential
warrants
attention.
emphasizes
importance
carefully
considered
responses
societies,
such
as
EANS,
ensure
neurosurgeons
continue
play
vital
managing
neurological
diseases.
Emphasis
ongoing
integration
techniques,
multidisciplinary
collaboration
essential
maintaining
field's
competence
quality
care.
