A Comprehensive Review of the Potential role of Human Cytomegalovirus (HCMV) Infections in Carcinogenesis DOI Open Access

Kosar Hosseini-Karkaj,

Abolfazl Jafari-Sales, Mehrdad Pashazadeh

et al.

Annals of Military and Health Sciences Research, Journal Year: 2024, Volume and Issue: 22(3)

Published: Sept. 23, 2024

: The herpesvirus family includes Human Cytomegalovirus (HCMV), a potent pathogen capable of infecting humans. In healthy individuals, this infection often presents without specific symptoms. After the initial infection, virus remains dormant in body but can reactivate later. Reactivation is one primary causes illnesses associated with HCMV. lifelong, and cannot be eliminated from human body. Although host cells mount an immune response following HCMV expresses genes that encode products countering adapting to response. commonly transmitted through bodily fluids. immunocompromised extremely dangerous may result severe, potentially life-threatening infections. For decades, researchers have been investigating potential link between cancer. Recent studies shown DNA virus-specific antibodies are present many types cancer, suggesting play significant role cancer development. Further research on its carcinogenesis will enhance our understanding facilitate development more effective prevention treatment strategies. study, we explore relationship

Language: Английский

Dormant cancer cells and polyploid giant cancer cells: The roots of cancer recurrence and metastasis DOI Creative Commons

Yuqi Jiao,

Yongjun Yu,

Minying Zheng

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(2)

Published: Feb. 1, 2024

Abstract Tumour cell dormancy is critical for metastasis and resistance to chemoradiotherapy. Polyploid giant cancer cells (PGCCs) with or multiple nuclei high DNA content have the properties of stem single PGCCs can individually generate tumours in immunodeficient mice. represent a dormant form that survive harsh tumour conditions contribute recurrence. Hypoxic mimics, chemotherapeutics, radiation cytotoxic traditional Chinese medicines induce formation through endoreduplication and/or fusion. After incubation, recover from treatment produce daughter strong proliferative, migratory invasive abilities via asymmetric division. Additionally, resist hypoxia chemical stress distinct protein signature involves chromatin remodelling cycle regulation. Dormant cellular basis therapeutic resistance, metastatic cascade disease This review summarises regulatory mechanisms governing entry exit dormancy, which may be used by PGCCs, potential strategies targeting PGCCs.

Language: Английский

Citations

11
A review of the carcinogenic potential of human papillomavirus (HPV) in urological cancers DOI Creative Commons

Ehsan Zolfi,

Farhood Khaleghi mehr,

Nikoo Emtiazi

et al.

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 28, 2025

Direct skin-to-skin contact during intimate sexual with a human papillomavirus (HPV)-positive individual is often the cause of HPV infection. In addition, many studies have been written up to date that look at role in growth other types tumors. Not all urological cancers are associated HPV. However, penile cancer (PC) caused by HPV, especially high-risk types. HPV-16 has most frequent (68.3%), followed HPV-6 (8.1%) and HPV-18 (6.9%). An increased risk getting certain urinary like prostate, bladder, testicular, kidney also linked these infections. Additionally, may play part continuous inflammation progression different organs tissues. So, making vaccine programs available more people male sex around world could significantly lower number The critical effects on urologic (UCs), such as penile, cancer, importance vaccination seen this study.

Language: Английский

Citations

1
Generation of glioblastoma in mice engrafted with human cytomegalovirus-infected astrocytes DOI Creative Commons
Joris Guyon, Sandy Haidar Ahmad, Ranim El Baba

et al.

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Language: Английский

Citations

6
Polyploidy in Cancer: Causal Mechanisms, Cancer-Specific Consequences, and Emerging Treatments DOI Open Access
Patrick Conway,

Jonathan Dao,

Dmytro Kovalskyy

et al.

Molecular Cancer Therapeutics, Journal Year: 2024, Volume and Issue: 23(5), P. 638 - 647

Published: Feb. 5, 2024

Abstract Drug resistance is the major determinant for metastatic disease and fatalities, across all cancers. Depending on tissue of origin therapeutic course, a variety biological mechanisms can support sustain drug resistance. Although genetic mutations gene silencing through epigenetic are culprits in targeted therapy, efflux polyploidization more global that prevail broad range pathologies, response to treatments. There an unmet need identify patients at risk polyploidy, understand underlying polyploidization, develop strategies predict, limit, reverse polyploidy thus enhancing efficacy standard-of-care therapy improve better outcomes. This literature review provides overview cancer offers perspective patient monitoring actionable therapy.

Language: Английский

Citations

5
Cellular Transformation by Human Cytomegalovirus DOI Open Access
Georges Herbein

Cancers, Journal Year: 2024, Volume and Issue: 16(11), P. 1970 - 1970

Published: May 22, 2024

Epstein–Barr virus (EBV), Kaposi sarcoma human (KSHV), papillomavirus (HPV), hepatitis B and C viruses (HBV, HCV), T-lymphotropic virus-1 (HTLV-1), Merkel cell polyomavirus (MCPyV) are the seven oncoviruses reported so far. While traditionally viewed as a benign causing mild symptoms in healthy individuals, cytomegalovirus (HCMV) has been recently implicated pathogenesis of various cancers, spanning wide range tissue types malignancies. This perspective article defines biological criteria that characterize oncogenic role HCMV based on new findings underlines critical for cellular transformation modeling tumor microenvironment already other oncoviruses.

Language: Английский

Citations

5
Environmental factors inducing gastric cancer: insights into risk and prevention strategies DOI Creative Commons

Puyi He,

Xiaomei Li,

Dan Zou

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 9, 2025

Gastric cancer, a prevalent malignant tumor worldwide, poses significant challenge to global health. Despite ongoing advancements in treatment methods, its high incidence and mortality rates remain concerning. Although progress treating gastric cancer is encouraging, more critical focus on enhancing prevention efforts. Understanding the risk factors associated with crucial for prevention. This article summarizes environmental related development of their prevention, including: Living or working environment (air pollution, water quality, soil radiation, altitude, climate), dietary habits (meat, high-fat diet, high-salt diet), lifestyle (smoking, Drinking, sleep, coffee), viral bacterial exposures (Epstein-Barr virus, Human cytomegalovirus, Helicobacter pylori). Additionally, discusses current research directions aims provide reference researchers, paving way future preventive therapeutic strategies.

Language: Английский

Citations

0
Human cytomegalovirus UL82 promotes cell cycle progression of colorectal cancer by upregulating AGR2 DOI Creative Commons
Haitao Ren, Bing Wang,

Lanni Wang

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 17, 2025

The correlation between persistent human cytomegalovirus (HCMV) infection and poor prognosis in colorectal cancer (CRC) patients has garnered increasing attention. UL82 is a tegument protein of HCMV, our previous research indicated that the presence significantly associated with reduced overall survival CRC patients. However, mechanism by which affects remains unclear. In this study, we investigated role progression through both vitro vivo experiments, revealed its downstream regulatory pathways integrating transcriptomics, metabolomics, proteomics. Our findings first promoted cell proliferation proportion cells S phase cycle. Additionally, enhanced expression oncogene AGR2, while knockdown AGR2 abolished proliferative effect UL82. Interestingly, interacted transcription factor DDX5, transcriptionally inhibited expression. Furthermore, UL82-AGR2 axis nucleotide metabolism enhancing levels synthesis enzymes DTYMK, RRM2, TYMS. conclusion, study suggests UL82/DDX5 complex may promote cycle upregulating serve as potential prognostic biomarker for Human promotes AGR2.

Language: Английский

Citations

0
EZH2-Myc Hallmark in Oncovirus/Cytomegalovirus Infections and Cytomegalovirus’ Resemblance to Oncoviruses DOI Creative Commons
Ranim El Baba, Georges Herbein

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 541 - 541

Published: March 19, 2024

Approximately 15–20% of global cancer cases are attributed to virus infections. Oncoviruses employ various molecular strategies enhance replication and persistence. Human cytomegalovirus (HCMV), acting as an initiator or promoter, enables immune evasion, supporting tumor growth. HCMV activates pro-oncogenic pathways within infected cells direct cellular transformation. Thus, demonstrates characteristics reminiscent oncoviruses. Cumulative evidence emphasizes the crucial roles EZH2 Myc in oncogenesis stemness. Myc, pivotal regulators processes, gain significance context oncoviruses This axis becomes a central focus for comprehending mechanisms driving virus-induced oncogenesis. Elevated expression is evident cancers, making it prospective target therapy. On other hand, deregulated over 50% human serves potent transcription factor governing processes contributing tumorigenesis; induces gene expression. The Myc/EZH2 plays critical role promoting growth Considering that has been shown manipulate axis, there emerging suggesting could be regarded potential oncovirus due its ability exploit this pathway implicated tumorigenesis.

Language: Английский

Citations

3
Polyploid Giant Cancer Cells: A Distinctive Feature in the Transformation of Epithelial Cells by High-Risk Oncogenic HCMV Strains DOI Creative Commons
Georges Herbein, Ranim El Baba

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1225 - 1225

Published: July 31, 2024

Human cytomegalovirus (HCMV) infection is common in tumor tissues across different types of cancer. While HCMV has not been recognized as a cancer-causing virus, numerous studies hint at its potential role cancer development where presence various cancers corresponds with the hallmarks Herein, we discuss and demonstrate that high-risk HCMV-DB BL strains have to trigger transformation epithelial cells, including human mammary cells (HMECs), ovarian (OECs), prostate (PECs), through generation polyploid giant (PGCCs). A discussion provided on how creates cellular environment promotes oncogenesis, supporting continuous growth CMV-transformed cells. The aforementioned transformed named CTH, CTO, CTP underwent cell cycling PGCC parallel dedifferentiation, displaying stem-like characteristics an epithelial-mesenchymal transition (EMT) phenotype. Furthermore, propose PGCCs, increased EZH2 expression, EMT, acquisition malignant traits represent deleterious response stress induced by oncogenic strains, latter being origin process upon leading adenocarcinoma poor prognosis.

Language: Английский

Citations

3
HPV and HCMV in Cervical Cancer: A Review of Their Co-Occurrence in Premalignant and Malignant Lesions DOI Creative Commons
Rancés Blanco, Juan P. Muñoz

Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1699 - 1699

Published: Oct. 30, 2024

Cervical cancer remains a significant global health concern, particularly in low- and middle-income countries. While persistent infection with high-risk human papillomavirus (HR-HPV) is essential for cervical development, it not sufficient on its own, suggesting the involvement of additional cofactors. The cytomegalovirus (HCMV) widespread β-herpesvirus known ability to establish lifelong latency reactivate under certain conditions, often contributing chronic inflammation immune modulation. Emerging evidence suggests that HCMV may play role various cancers, including cancer, through potential influence oncogenic pathways disrupt host responses. This review explores clinical regarding co-presence HR-HPV premalignant lesions cancer. literature reviewed indicates frequently detected lesions, those co-infected HPV, synergistic interaction could enhance HPV's effects, thereby facilitating progression from low-grade squamous intraepithelial (LSIL) high-grade (HSIL) invasive Although precise molecular mechanisms were thoroughly investigated this review, importance considering alongside HPV management lesions. A better understanding between lead improved diagnostic, therapeutic, preventive strategies

Language: Английский

Citations

3