Exploring cell death pathways in oral cancer: mechanisms, therapeutic strategies, and future perspectives

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Oral squamous cell carcinoma (OSCC) represents a significant global health challenge, characterized by aggressive progression and poor therapeutic response despite advances in treatment modalities. This review provides comprehensive analysis of diverse death mechanisms OSCC, encompassing traditional pathways (apoptosis, autophagy, necrosis), newly (ferroptosis, pyroptosis, necroptosis), emerging (cuproptosis, anoikis, parthanatos, entosis). By examining the molecular basis these pathways, particularly crucial roles p53 signaling miRNA regulation, we highlight how their dysregulation contributes to resistance tumor progression. The synthesizes recent evidence demonstrating complex interplay between ten distinct impact on microenvironment immune response. We evaluate innovative approaches that target including novel small molecules, combination strategies, immunomodulatory treatments exploit specific enhance efficacy. Special attention is given personalized medicine strategies consider individual characteristics pathway profiles. integrating current challenges with future research directions, this framework for developing more effective can leverage multiple overcome therapy improve outcomes oral cancer patients.

Language: Английский

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Regulated cell death mechanisms in mitochondria-targeted phototherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113720 - 113720

Published: April 1, 2025

Language: Английский

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Neutrophil-mimetic hybrid liposome with ROS cascade amplification for synergistic ferroptosis-photodynamic therapy of breast cancer

Nano Research, Journal Year: 2024, Volume and Issue: 17(11), P. 9932 - 9941

Published: Aug. 13, 2024

Language: Английский

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Glutathione‐Depleted Photodynamic Nanoadjuvant for Triggering Nonferrous Ferroptosis to Amplify Radiotherapy of Breast Cancer

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 13, 2024

Abstract Radiotherapy plays a crucial role in the treatment of advanced breast cancer, but increased antioxidant system, especially rise glutathione (GSH), presents significant obstacle to its effectiveness. To address this challenge, versatile GSH‐depleted photodynamic nanoadjuvant is developed augment efficacy radiotherapy for cancer treatment. This operates within tumor microenvironment effectively deplete intracellular GSH through sequence cascaded processes, including exhaustion, biosynthetic inhibition, and oxidation. leads notable accumulation lipid peroxides (LPO) subsequent suppression peroxidase 4 (GPX4) activity. Consequently, combined depletion induced by markedly promotes nonferrous ferroptosis, thereby contributing augmentation antitumor efficiency during cancer. work an innovative approach designing synthesizing biocompatible nanoadjuvants with goal improving prospective clinical scenarios.

Language: Английский

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Ferroptosis, Metabolic Rewiring, and Endometrial Cancer

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 75 - 75

Published: Dec. 20, 2023

Ferroptosis is a newly discovered form of regulated cell death. The main feature ferroptosis excessive membrane lipid peroxidation caused by iron-mediated chemical and enzymatic reactions. In normal cells, harmful peroxides are neutralized glutathione peroxidase 4 (GPX4). When GPX4 inhibited, occurs. mammalian serves as tumor suppression mechanism. Not surprisingly, in recent years, induction has gained attention potential anticancer strategy, alone or combination with other conventional therapies. However, sensitivity to inducers depends on the metabolic state cell. Endometrial cancer (EC) sixth most common world, more than 66,000 new cases diagnosed every year. Out all gynecological cancers, carcinogenesis EC mostly dependent abnormalities. Changes uptake catabolism iron, lipids, glucose, glutamine affect redox capacity cells and, consequently, their ferroptosis-inducing agents. addition this, ferroptosis-related genes usually mutated overexpressed, which makes promising target for prediction, diagnosis, therapy. successful application ferroptosis, connection between rewiring needs be deciphered, focus this review.

Language: Английский

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Glycopolymeric Photoactive Micelles for Glucose Transporter-Targeted Synergistic Combination Therapy

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(7), P. 4149 - 4163

Published: March 21, 2024

Drug delivery systems for cancer therapy have been investigated to alter the properties of therapeutic molecules through covalent/noncovalent interactions, lessen harmful side effects, and enhance outcomes. Nevertheless, it is important sustain targeting ability drug platforms, which are beneficial progress precision medicine. In present study, a series protoporphyrin IX (PpIX)-containing glucose fructose-based-glycoblock copolymers were synthesized via reversible addition–fragmentation chain transfer (RAFT) polymerization click coupling reaction. Glycopolymeric photoactive micelles (GPMs) based on glycoblock (P(G/FMAlPpIXm-b-nBAn); l = 25, m 5, n 75) prepared with antineoplastic loadings (paclitaxel, PTX) using nanoprecipitation method. Glycosylated fructosylated GPMs -GPM1–PTX GPM2–PTX, respectively- different diameters (127.02 121.20 nm) serve as suppliers reactive oxygen species (ROS) PTX. This dual-engineered glyconanomedicine effectively induces synergistic interference against breast owing dual-modal effect mediated by PpIX/PTX transporter (GLUT) targeting. Moreover, GPM1–PTX GPM2–PTX overperformed 4.0 1.8 times lower IC50 values in cytotoxicity assays had 3.59 3.55 higher apoptosis/necrosis rates upon light irradiation when compared that combined free drugs formulation (PpIX + cells vitro, respectively. Therefore, this work contributes platform establishing benefit GLUT-targeted photodynamic-chemotherapy, suggesting better than monotherapy: PpIX, PTX well.

Language: Английский

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Facile synthesis of MoS2@red phosphorus heterojunction for synergistically photodynamic and photothermal therapy of renal cell carcinoma

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 114031 - 114031

Published: June 12, 2024

Language: Английский

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Cold Plasma Irradiation Inhibits Skin Cancer via ferroptosis

Biomedical Physics & Engineering Express, Journal Year: 2024, Volume and Issue: 10(6), P. 065036 - 065036

Published: Oct. 1, 2024

Abstract Cold atmospheric plasma (CAP) has been extensively utilized in medical treatment, particularly cancer therapy. However, the underlying mechanism of CAP skin treatment remains elusive. In this study, we established a model using vitro . Also, Xenograft experiment vivo The results demonstrated that with induced ferroptosis, resulting significant reduction viability, migration, and invasive capacities A431 squamous cell carcinoma, type cancer. Mechanistically, production reactive oxygen species (ROS) by induces DNA damage, which then activates Ataxia-telangiectasia mutated (ATM) p53 through acetylation, while simultaneously suppressing expression Solute Carrier Family 7 Member 11 (SLC7A11). Consequently, cascade led to down-regulation intracellular Glutathione peroxidase 4 (GPX4), ultimately ferroptosis. exhibits favorable impact on suggesting its potential application

Language: Английский

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Ce6-modified Fe Ions-doped Carbon Dots as Multifunctional Nanoplatform for Ferroptosis and Photodynamic Synergistic Therapy of Melanoma

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 10, 2024

Abstract Background Despite the higher sensitivity of melanoma towards ferroptosis and photodynamic therapy (PDT), lack efficient inducers poor solubility photosensitizers restrict their synergistic strategies. With unique advantages, carbon dots (CDs) are expected to serve as innovative building blocks for combination cancers. Results Herein, an ferroptosis/PDT integrated nanoplatform is constructed based on chlorin e6-modified Fe ions-doped (Fe-CDs@Ce6). As novel type iron-carbon hybrid nanoparticles, as-prepared Fe-CDs can selectively activate ferroptosis, prevent angiogenesis inhibit migration mouse skin cells (B16), but have no toxicity normal cells. The nano-conjugated structures facilitate not only aqueous dispersibility Ce6, also self-accumulation ability Fe-CDs@Ce6 within area without requiring extra targets. Moreover, therapeutic effects synergistically enhanced due increased GSH depletion by PDT elevated singlet oxygen ( 1 O 2 ) production efficiency Fe-CDs. When combined with laser irradiation, tumor growth be significantly suppressed through cyclic administration. T -weighted magnetic resonance imaging (MRI) capability reveals potentials cancer diagnosis navigation therapy. Conclusions Our findings indicate multifunctionality in effectively combining therapy, targeting MRI imaging, which enables become promising biocompatible treatment melanoma.

Language: Английский

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Hypericin mediated photodynamic therapy induces ferroptosis via inhibiting the AKT/mTORC1/GPX4 axis in cholangiocarcinoma

Translational Oncology, Journal Year: 2024, Volume and Issue: 52, P. 102234 - 102234

Published: Dec. 13, 2024

Language: Английский

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