Association between Chinese visceral adiposity index and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH): a national cohort study

BMC Urology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 23, 2025

Benign prostatic hyperplasia (BPH) and its related lower urinary tract symptoms (LUTS) are commonly observed among aging males have a substantial effect on quality of life. Metabolic syndrome, with specific focus obesity, is believed to play role in the development BPH. This study intends explore relationship between several obesity-related metrics, including Chinese Visceral Adiposity Index (CVAI), LUTS/BPH within national cohort men. Data from China Health Retirement Longitudinal Study (CHARLS) 2015 were analyzed, encompassing sample 5,735 male participants aged 45 older. Eight indices—namely Body mass index (BMI), Waist-height ratio (WHtR), Triglyceride-glucose.BMI (TyG.BMI), TyG. Waist circumference (TyG.WC), TyG.WHtR, CVAI, adiposity (VAI), A body shape (ABSI)—were examined. Logistic regression models, adjusted for potential confounders, utilized evaluate associations these indices LUTS or The predictive capabilities further assessed using receiver operating curves (ROC). Among participants, 718 (12.5%) diagnosed LUTS/BPH. All significantly higher group compared healthy group. CVAI demonstrated highest ability LUTS/BPH, an area under curve (AUC) 0.58. highlighted nonlinear indices, CVAI. underscores significant association visceral fat, as measured by risk emerged most effective predictor evaluated, suggesting utility identifying individuals at Further prospective studies needed confirm findings elucidate underlying mechanisms.

Language: Английский

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Evaluation of the therapeutic potential of Garcinia cambogia alone or in combination with Silodosin in the management of LUTS/BPH: A prospective randomized controlled study

Urology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Metabolic insights into hypoxia adaptation in adolescent athletes at different altitudes: a cross-sectional study

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: May 9, 2025

Athletes use hypoxic training methods to enhance their performance under altitude conditions. Comparative studies involving populations from low (500–2,000 m) and moderate (2,000–3,000 altitudes offer an opportunity understand the mechanisms behind adaptations hypoxia. The present study combined data metabolomics analysis based on gas- liquid-chromatography mass spectrometry (GC-MS LC-MS) compare plasma profiles 80 adolescent athletes at moderate- or altitudes. 161 metabolites were identified, including 84 elevated 77 decreased in moderate-altitude adolescents compared low-altitude counterparts. Pathway revealed that related carbohydrates, amino acids, lipid metabolism differed between groups. Lipid was significantly altered athletes, pathways such as linolenic linoleic acid, sphingolipid, arachidonic well processes transfer of acetyl groups into mitochondria fatty acid biosynthesis. Biomarker looking for signatures chronic adaptation identified glycerol 5-oxoproline amongst variables with strongest sensitivity specificity. This demonstrates differences metabolic highlights potential these differential associated provide new insights altitude.

Language: Английский

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Plasma metabolites as mediators in the relationship between inflammation-related proteins and benign prostatic hyperplasia: insights from mendelian randomization

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 30, 2024

Benign prostatic hyperplasia (BPH) is a condition commonly observed in aging males. Inflammatory and metabolic factors are pivotal the development progression of BPH. The degree to which effects 91 inflammation-related proteins on BPH mediated by 1400 plasma metabolites remains ambiguous. Our research analyzed impact these traits utilizing genetic evidence.Two-sample Mendelian randomization (MR) multivariable MR (MVMR) were utilized our study infer causal effect BPH, with serving as mediators. Increased levels IL-2 linked heightened incidence (β = 0.071, OR:1.074, 95% CI [1.002-1.152], p 0.045), whereas lower concentrations N6,N6-dimethyllysine associated decreased risk (β1=-0.127, 0.02; β2=-0.039, 0.008). mediation was 0.005 (95% [0.0004, 0.012], OR: 1.005, [1.000, 1.012]), accounting for 7.04% total effect. subsequently, we examined phenotypic co-localization two pairings independently, revealing that posterior probability rs145516501 80.7%, likelihood rs4917820 95.9%. indicated seem influence causative relationship between These results elucidate complex interplay metabolism context offering novel diagnostic therapeutic avenues enhancing comprehension disease's etiology prospective research.

Language: Английский

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Combining untargeted and targeted metabolomics to reveal the mechanisms of herb pair Anemarrhena asphodeloides Bunge and Phellodendron chinense C. K. Schneid on benign prostatic hyperplasia

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118539 - 118539

Published: Nov. 1, 2024

Language: Английский

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Effects of Prostatic Inflammation on Clinical Outcomes in Patients with Benign Prostate Hyperplasia

Journal of Health and Rehabilitation Research, Journal Year: 2024, Volume and Issue: 4(1), P. 471 - 476

Published: Feb. 7, 2024

Background: Benign prostate hyperplasia (BPH), a non-cancerous enlargement of the gland, prevalently impacts aging male population, often disrupting quality life with its accompanying urinary symptoms. The intersection between BPH and prostatic inflammation has emerged as focal point in urological research, speculated to exacerbate progression Understanding this relationship is pivotal refining therapeutic approaches improving patient outcomes. Objective: This study aimed elucidate effects on clinical outcomes patients BPH, focusing symptom progression, treatment efficacy, long-term complications. Methods: Study Conducted at Gajju Khan Medical College Swabi, KPK, Pakistan, duration from January, 2023 June, 2023. prospective cohort involved 126 men categorized into two groups based presence (n=63) or absence inflammation. Data were collected over three years, assessments including demographic information, histories, examinations. Primary measured symptoms, function, size. Secondary included life, acute retention, need for surgical intervention, medication Statistical analyses employed Chi-square tests, t-tests, ANOVA, SPSS software. Results: group showed significantly more severe (p < 0.01), impaired function increased size 0.01) compared non-inflamed group. also favored better scores (75.2 ± 5.2 vs. 78.8 4.8, p lower rates retention (20.3% 15.5%, 0.01). Conclusion: Prostatic worsens affecting response, likelihood These findings suggest integrated strategies that address both optimize care.

Language: Английский

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Plasma metabolites as mediators in inflammation-related proteins - benign prostatic hyperplasia risk: insights from Mendelian randomization

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

Benign prostatic hyperplasia (BPH) is a chronic disease that pretends to occur in elderly men. Inflammatory and metabolic factors play key role the pathogenesis progression of BPH. The extent which effects 91 inflammation-related proteins on BPH are mediated by 1400 plasma metabolites unclear. In our study we examined these traits using genetic evidence. We used two-sample Mendelian randomization ( MR) Multivariable MR (MVMR) determine:there causal relationship between Interleukin-2 levels (IL-2)and BPH,N6,N6-dimethyllysine mediation role:higher IL-2 was associated with higher risk BPH(β = 0.071, OR:1.074,95%CI[1.002–1.152],p 0.045 lower N6,N6-dimethyllysine (β1=-0.127 p 0.02).The (β2=-0.039,p 0.008) negatively BPH.The effect 0.005,95% confidence interval(CI) [0.0004,0.012],odds-ratio (OR) :1.005,95%CI[1.000,1.012].Then,we analyzed phenotypic co-localization two pairs : IL-2—BPH levels—BPH, showed co-locate SNP rs145516501 NO. 13 chromosome. levels, co-located rs4917820 10 chromosome.The proportion 7.04%.The suggested appear mediate

Language: Английский

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Altered amino and fatty acids metabolism in Sudanese prostate cancer patients: insights from metabolic analysis

Journal of Circulating Biomarkers, Journal Year: 2024, Volume and Issue: 13(1), P. 36 - 44

Published: Dec. 16, 2024

Introduction: Prostate cancer (PCa) management presents a multifaceted clinical challenge, intricately linking oncological considerations with cardiovascular health. Despite the recognized importance of lipid metabolism and hypertension in this interwoven relationship, their involvement PCa development remains partially understood. This study aimed to explore variations plasma metabolome among Sudanese patients associated comorbidities. Methods: Plasma samples were collected from 50 across four hospitals Sudan profiled by nuclear magnetic resonance (NMR) spectroscopy. One-dimensional proton NMR spectra acquired for each sample using standard Overhauser effect spectroscopy pulse sequence presat on 500 MHz Bruker Avance III HD spectrometer. Metabolite concentrations quantified R scripts developed in-house. Univariate multivariate analyses generated software. Results: Patients categorized into distinct metabotypes based metabolic profiles, statistical conducted evaluate significance observed differences. Our findings revealed high levels fatty acids, phospholipids, cholesterol, valine, leucine, isoleucine non-hypertensive patients. In contrast, hypertensive GlycA GlycB altered amino acid metabolism. Conclusion: These underscore intricate interplay between dysregulation Further research is warranted elucidate precise molecular pathways underlying therapeutic potential targeting these pathways. conclusion, our contributes deeper understanding landscape patients, emphasizing personalized approaches management.

Language: Английский

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