Exploring the Link between Head and Neck Cancer and Elevated Risk of Rheumatoid Arthritis: A National Population-Based Cohort Study

Cancers, Journal Year: 2024, Volume and Issue: 16(6), P. 1081 - 1081

Published: March 7, 2024

An increased risk of cancer among patients with rheumatoid arthritis (RA) has been reported. However, the RA events head and neck (HNC) is unknown. Therefore, we investigated incidence HNC. This study was based on a cohort dataset. Overall, 2824 individuals without HNC 706 were selected using propensity score matching. The overall event rate 12.19 for 7.60 those A significantly developing also observed over time relatively high within first year after diagnosis; further, it during follow-up period. Moreover, middle-aged male exhibited an compared controls; however, no significant difference noted female or other age groups. Notably, subgroup analysis according to subtype revealed that only oral survivors had RA. These results underscore importance vigilant monitoring by clinicians promptly identify onset in

Language: Английский

Alzheimer’s disease and oral manifestations: a bi-directional Mendelian randomization study

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: May 15, 2024

Epidemiological studies have provided evidence suggesting an association between Alzheimer's disease (AD) and various oral manifestations. However, conflicting conclusions been drawn, whether a causal truly exists remains unclear. In order to investigate the potential AD prevalent diseases, we conducted bi-directional two-sample Mendelian randomization analysis based on summary statistics from genome-wide of (N = 63,926), as well mouth ulcer 461,103), cavity cancer 4,151), periodontal 527,652). We identified that one standard increase in risk was causally associated with reduced (OR 0.76, 95% CI: 0.63-0.92, p 3.73 × 10-3). opposite direction, conditions were not AD. The present findings contributed better understanding correlation conditions, specifically cancer. These results also new avenues for exploring underlying mechanisms

Language: Английский

Characterizing Physiologic Swallowing Impairment Profiles: A Large-Scale Exploratory Study of Head and Neck Cancer, Stroke, Chronic Obstructive Pulmonary Disease, Dementia, and Parkinson's Disease

Journal of Speech Language and Hearing Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Nov. 18, 2024

Purpose: The purpose of the present study was to use a large swallowing database explore and compare swallow-physiology impairment profiles five dysphagia-associated diagnoses: chronic obstructive pulmonary disease (COPD), dementia, head neck cancer (HNC), Parkinson's (PD), stroke. Method: A total 8,190 patients across diagnoses were extracted from de-identified database, that is, Modified Barium Swallow Impairment Profile Swallowing Data Registry, for exploratory cross-sectional analysis. To identify diagnoses, we fit 18 partial proportional odds models, one each 17 components Penetration–Aspiration Scale, with score as dependent variable age, sex, race independent variables interactions between age PD dementia (in effect creating [PDwDem] group). For > 5% missingness, applied inverse probability weighting correct bias. Results: COPD did not significantly differ on 13 outcome (all p s .02). Dementia, stroke, PDwDem all showed worse impairments than or six oral < .007). HNC had except nine 10 pharyngeal .006). Stroke penetration/aspiration other .003). Conclusions: results show there are both common differing among these diagnoses. These commonalities differences in provide basis generation hypotheses about nature severity dysphagia populations. also likely highly generalizable given size representativeness data set. Supplemental Material: https://doi.org/10.23641/asha.27478245

Language: Английский