Seeing clearly to treat precisely: Advances in molecular imaging and theranostics in precision health DOI
Christopher H. Contag

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 67 - 82

Published: Nov. 29, 2024

Language: Английский

From antibodies to nanobodies: The next frontier in cancer theranostics for solid tumors DOI
Sanjana Mehrotra, Navdeep Kaur, Sukhpreet Kaur

et al.

Advances in protein chemistry and structural biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Aptamers and Nanobodies as New Bioprobes for SARS-CoV-2 Diagnostic and Therapeutic System Applications DOI Creative Commons
Ki Sung Park, Tae-In Park,

Jae Eon Lee

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(3), P. 146 - 146

Published: March 15, 2024

The global challenges posed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have underscored critical importance of innovative and efficient control systems for addressing future pandemics. most effective way to is rapidly suppress spread virus through early detection using a rapid, accurate, easy-to-use diagnostic platform. In biosensors that use bioprobes, binding affinity molecular recognition elements (MREs) primary factor determining dynamic range sensing Furthermore, sensitivity relies mainly on bioprobe quality with sufficient functionality. This comprehensive review investigates aptamers nanobodies recently developed as advanced MREs SARS-CoV-2 therapeutic applications. These bioprobes might be integrated into organic bioelectronic materials devices, promising enhanced specificity. offers valuable insights advancing biosensing technologies infectious disease diagnosis treatment new bioprobes.

Language: Английский

Citations

6
Next-Generation Therapeutic Antibodies for Cancer Treatment: Advancements, Applications, and Challenges DOI
A. Raja,

Abhishek Kasana,

Vaishali Verma

et al.

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Language: Английский

Citations

6
GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy DOI Creative Commons

Huifang Wang,

Runhua Zhou, Chengchao Xu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

The lack of targetable antigens poses a significant challenge in developing effective cancer-targeted therapies. Cell surface translocation endoplasmic reticulum (ER) chaperones, such as glucose-regulated protein 78 (GRP78), during malignancy, drug resistance, and ER stress induced by therapies, offers promising pan-cancer target. To target GRP78, nanobody C5, identified from phage library exhibiting high affinity for human mouse is utilized to develop the Pseudomonas exotoxin (PE) immunotoxin C5-PE38. C5-PE38 stress, apoptosis immunogenic cell death targeted cells showed antitumor efficacy against colorectal cancer melanoma models without obvious toxicity. Mechanistically, transcriptome profiling that reshaped tumor immune microenvironment with enhanced innate adaptive response interferon beta. Moreover, C5-PE38-induced could trans-activate STING pathway dendritic macrophages, promoting CD8+ T infiltration. It also sensitizes both primary metastatic melanomas anti-PD1 therapy, partly through activation. Overall, this study unveils feasible GRP78 nanobody-directed therapy strategy single or combinatorial intervention. This work finds stimulates STING-dependent cytosolic DNA release promote immunity, mechanism not previously reported PE38, providing valuable insights its clinical use.

Language: Английский

Citations

0
Advancements in nanobody-based immunodiagnostics and infectious pathogens, foodborne hazards, and human biomarkers DOI
Yawen Liu, Jiajie Liu, Z. Q. Qiu

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 114083 - 114083

Published: May 1, 2025

Language: Английский

Citations

0
The cutting edge: Promising oncology radiotracers in clinical development DOI
Jorge D. Oldan, Martin G. Pomper, Rudolf A. Werner

et al.

Diagnostic and Interventional Imaging, Journal Year: 2024, Volume and Issue: 105(10), P. 400 - 406

Published: May 14, 2024

Language: Английский

Citations

3
Challenges and opportunities in single-domain antibody-based tumor immunotherapy DOI
Xiaozhi Xi,

Guo Shu-hua,

Yuchao Gu

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189284 - 189284

Published: Feb. 1, 2025

Language: Английский

Citations

0
Seeing clearly to treat precisely: Advances in molecular imaging and theranostics in precision health DOI
Christopher H. Contag

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 67 - 82

Published: Nov. 29, 2024

Language: Английский

Citations

0