Nanomedicines: Emerging Platforms in Smart Chemotherapy Treatment—A Recent Review

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 315 - 315

Published: Feb. 28, 2024

Cancer continues to pose one of the most critical challenges in global healthcare. Despite wide array existing cancer drugs, primary obstacle remains selectively targeting and eliminating cells while minimizing damage healthy ones, thereby reducing treatment side effects. The revolutionary approach utilizing nanomaterials for delivering therapeutic agents has significantly enhanced efficacy safety chemotherapeutic drugs. This crucial shift is attributed unique properties nanomaterials, enabling nanocarriers transport tumor sites both passive active modes, drug elimination from delivery systems. Furthermore, these can be designed respond internal or external stimuli, thus facilitating controlled release. However, production nanomedications therapy encounters various that impede progress this field. review aims provide a comprehensive overview current state nanomedication treatment. It explores variety focusing on their are overcoming limitations conventional chemotherapy. Additionally, delves into functionalities nanocarriers, highlighting significant impact evolution nanomedicine. also critically assesses recent advancements systems, covering range innovative methodologies. Finally, succinctly addresses encountered developing nanomedications, offering insightful perspectives guide future research

Language: Английский

---

Superparamagnetic polyhemoglobin-tyrosinase nanocapsules: a novel biotherapeutic with enhanced tumor suppression with control by external magnetic field

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 30, 2025

Our recent study shows nanobiotherepeutic Polyhemoglobin-Tyrosinase-Nanocapsules (PolyHb-Tyr-Nano) have strong anti-tumor abilities in multiple cancer lines. However, despite their tumor inhibitory potential, some internal sites can be difficult to reach. In this paper, based on Chang's original finding that artificial cells containing magnetic material controlled by external fields, using nanoprecipitation methods, we modified biotechnological nanotherapeutic with superparamagnetic properties, which shown attracted and guided magnets. By fluorescence microscopy, show field improved the local deposition of nanorobotic PolyHb-Tyr-nano at microenvironment (TME), significantly preventing clearance, stay site repeated washings. This allowed time for them enter act intracellularly. cell proliferation tests migration study, action four lines: Hepa 1-6 liver line, A549 lung HeLa cervical MCF7 breast line are also retained effective, a low viability was observed. Furthermore, addition property has enhanced nanocapsules uptake abilities, drug effect cells. Via test, PAL assay, oxidative stress detection, mitochondria membrane potential studies, killing, amino acid reduction, reactive oxygen species (ROS) generation, activity reduction presence fields. results showed efficacy novel nanobiotherapeutic future therapy, enhance localization, targeted delivery, combination therapies.

Language: Английский

---

Nanoparticles with Core-Shell structure as efficient recoverable corrosion inhibitors for mild steel in acidic media

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137973 - 137973

Published: May 1, 2025

Language: Английский

---

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Metastasis is the leading cause of death in patients with lung cancer. Multidisciplinary comprehensive treatments (MDT), including surgery, chemotherapy, radiotherapy, gene-targeted therapy, immunotherapy, antibody-drug conjugate (ADC), natural products, etc., have been currently used for cancer metastasis. The MDT model has shown promising efficacy against metastasis clinical practice. However, these therapies some limitations, such as unusual toxic side effects, drug resistance, limited indications, and high costs. Therefore, emerging technological platforms are imperative to overcome bottlenecks. Nanomedicine can be prepare efficient delivery systems owing its good biocompatibility, targeting, responsive release, multidrug codelivery plays an important role synergistic antimetastasis because optical, acoustic, electrical, thermal, magnetic functions. This review analyses limitations model, briefly outlines advantages nanotechnology, introduces nanodrug systems, summarizes nanostrategies based on invasion-metastasis cascade process, provides a summary prospects challenges translation nanomedicines.

Language: Английский

---

Enhanced functionalization of superparamagnetic Fe3O4 nanoparticles for advanced drug enrichment and separation applications

BMC Chemistry, Journal Year: 2024, Volume and Issue: 18(1)

Published: Sept. 19, 2024

---