Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 16, 2024
Abstract
We
investigated
the
association
of
prediagnostic
use
menopausal
hormone
therapy
(MHT)
with
breast
cancer
survival
among
women
type
2
diabetes
(T2D).
The
study
cohort
was
identified
from
a
Finnish
nationwide
database,
and
consisted
T2D,
who
were
diagnosed
between
2000
2011
(n
=
3189).
patients
classified
according
to
their
previous
MHT
use:
systemic
MHT,
local
no
history
any
MHT.
cumulative
mortality
cancer,
cardiovascular
diseases,
other
causes
in
three
groups
described
by
Aalen-Johansen
estimator.
cause-specific
rates
analyzed
Cox
models,
adjusted
hazard
ratios
(HRs)
estimated
for
appeared
be
lower
users
(HR
0.49,
95%
Cl
0.36–0.67)
compared
non-users
diseases
death
found
users,
0.32–0.74),
0.51,
0.35–0.76),
respectively.
In
conclusion,
is
associated
reduced
cardiovascular,
T2D.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 1, 2025
Breast
cancer
is
a
significant
healthcare
challenge,
and
despite
advancements
in
treatment,
the
risk
of
recurrence
remains
critical
concern,
particularly
for
postmenopausal
women.
Understanding
factors
that
contribute
to
this
essential
improving
monitoring
prevention
strategies,
ultimately
enhancing
long-term
care
disease
management
patient
population.
The
study
analyzes
scholarly
literature
on
patterns
Caucasian
women
with
prior
breast
cancer,
highlighting
potential
innovative
insights
reduce
mortality
improve
survival.
We
used
R
software
"R-Bibliometrix"
package
analyze
recurrence.
Data
was
collected
from
Web
Science
Core
Collection
database
identify
relevant
documents
highlight
collaborative
efforts
commonly
terminology.
extensive
analysis
included
500
articles
authored
by
3,204
individuals
195
distinct
sources,
all
published
between
2010
2024.
It
specifically
focused
assessing
results
underscored
several
influencing
recurrence,
encompassing
hormonal
factors,
lifestyle
influences,
effectiveness
various
types
adjuvant
therapy,
role
genetic
factors.
In
conclusion,
research
highlights
multifaceted
nature
contributing
believe
not
only
enhances
current
understanding
but
also
provides
clear
directions
future
improvements
clinical
practice
health
policy.
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 18
Published: April 22, 2025
Breast
cancer
is
one
of
the
most
common
types
cancer,
however,
preventive
screening
has
contributed
to
a
significant
reduction
in
mortality
over
past
four
decades.
The
first-line
methods
for
breast
such
as
mammography
and
tomosynthesis,
are
x-ray-based
modalities.
Unfortunately,
their
detection
rates
low
patients
with
dense
breasts.
These,
other
high-risk
women,
now
encouraged
receive
supplemental
screening.
imaging
diverse,
including
ultrasound,
MRI,
nuclear
imaging,
X-ray-based
modalities
CT
contrast-enhanced
mammography/tomosynthesis.
Due
cost
wide
availability,
see
clinical
use
worldwide.
These
techniques
benefit
from
contrast
agents,
which
currently
iodinated
small
molecules
designed
purposes.
Consequently,
developing
new
agents
that
specifically
interest.
This
review
describes
these
nanoparticle-based
being
researched
enhanced
performance.
relevant
parameters
agent
design
evaluated,
generation
potential
biointeractions.
Iodinated
discussed
comparison.
Nanoparticles
covered
include
silver
sulfide,
telluride,
gold,
bismuth
sulfide-based
among
others.
Finally,
perspectives
on
future
developments
this
field
offered.
npj Imaging,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: Feb. 19, 2024
There
are
limited
options
for
primary
prevention
of
breast
cancer
(BC).
Experimental
procedures
to
locally
prevent
BC
have
shown
therapeutic
efficacy
in
animal
models.
To
determine
the
suitability
FDA-approved
iodine-containing
and
various
metal-containing
(bismuth,
gold,
iodine,
or
tantalum)
preclinical
nanoparticle-based
contrast
agents
image-guided
intraductal
(ID)
ablative
treatment
rodent
models,
we
performed
a
prospective
longitudinal
study
imaging
performance,
local
retention
systemic
clearance,
safety
profile,
compatibility
with
solution
each
agent.
At
least
six
abdominal
mammary
glands
(>3
female
FVB/JN
mice
and/or
Sprague-Dawley
rats,
10-11
weeks
age)
were
intraductally
injected
commercially
available
(Omnipaque
Geburtshilfe und Frauenheilkunde,
Journal Year:
2024,
Volume and Issue:
84(06), P. 541 - 554
Published: June 1, 2024
Abstract
Breast
cancer
(BC)
stands
as
a
global
concern,
given
its
high
incidence
and
impact
on
women’s
mortality.
This
complex
disease
has
roots
in
various
risk
factors,
some
modifiable
others
not.
Understanding
identifying
these
factors
can
be
instrumental
both
preventing
BC
improving
survival
rates.
Remarkably,
reproductive
behaviors
have
emerged
critical
determinants
of
susceptibility.
Numerous
studies
shed
light
how
aspects
including
age
menarche,
first
pregnancy
menopause
along
with
number
pregnancies,
hormone
replacement
therapies,
influence
one’s
developing
BC.
Furthermore,
the
act
breastfeeding
duration
shown
an
inverse
relationship
risk.
review
delves
into
biological
molecular
mechanisms
associated
that
contribute
to
protection.
It
highlights
role
endocrine
processes
triggered
by
suckling
stimulation,
gradual
onset
lactational
amenorrhea,
delayed
weaning,
reduced
lifetime
menstrual
cycles,
chromosomal
repair
mechanisms,
immunological
events
throughout
lactation
cycle.
These
insights
provide
potential
explanation
for
protective
effects
conferred
against
breast
carcinomas.
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: July 5, 2024
Objectives
This
study
aimed
to
develop
a
deep
learning
radiomic
model
using
multimodal
imaging
differentiate
benign
and
malignant
breast
tumours.
Methods
Multimodality
data,
including
ultrasonography
(US),
mammography
(MG),
magnetic
resonance
(MRI),
from
322
patients
(112
with
tumours
210
tumours)
histopathologically
confirmed
were
retrospectively
collected
between
December
2018
May
2023.
Based
on
imaging,
the
experiment
was
divided
into
three
parts:
traditional
radiomics,
feature
fusion.
We
tested
performance
of
seven
classifiers,
namely,
SVM,
KNN,
random
forest,
extra
trees,
XGBoost,
LightGBM,
LR,
different
models.
Through
fusion
ensemble
stacking
strategies,
we
obtained
optimal
classification
for
Results
In
terms
strategy
achieved
highest
accuracy,
AUC,
specificity,
values
0.892,
0.942
[0.886–0.996],
0.956
[0.873–1.000],
respectively.
The
early
US,
MG,
MRI
sensitivity
0.952
[0.887–1.000].
sensitivity,
0.937,
0.947
[0.887–1.000],
1.000
[0.999–1.000],
strategies
US+MRI
US+MG
specificity
0.954
[0.867–1.000].
fusion,
approaches
late
accuracy
0.968.
addition,
AUC
which
0.997
[0.990–1.000]
depth
features
+
MR
[0.999–1.000]
under
strategy.
Conclusion
demonstrated
potential
integrating
images.
As
single
modality,
based
greater
than
US
or
MG.
MG
models
higher
transfer
single-mode
strategy,
showed
diagnostic
performance,
provided
more
valuable
information
differentiation
Journal of Education Health and Sport,
Journal Year:
2024,
Volume and Issue:
69, P. 49454 - 49454
Published: May 16, 2024
Individuals
with
BRCA1
and
BRCA2
mutations
face
significantly
heightened
likelihood
of
developing
breast
ovarian
cancers.
Besides
some
lifestyle
recommendations,
like
maintaining
physical
activity,
healthy
BMI,
possibly
early
parenthood
breastfeeding,
the
management
BRCA1/2
mutation
carriers
includes
gene
early-detection,
screening,
risk-reducing
surgeries,
chemoprevention.
Various
prevention
strategies
exist,
all
aimed
at
monitoring
patients
mitigating
cancer
risks.
However,
even
existence
national
international
guidelines
to
direct
efforts,
there
is
no
ideal
protocol
that
would
be
universally
applicable
for
individuals
mutated
BRCA
gene.
This
article
aims
delve
into
currently
available
surveillance
preventive
explore
potential
future
avenues
detection
risk
reduction
in
carriers.
