Unveiling sialoglycans’ immune mastery in pregnancy and their intersection with tumor biology DOI Creative Commons
Jianmei Huang, Feng Lu, Jianming Huang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 20, 2024

Sialylation is a typical final step of glycosylation, which prevalent post-translational modification proteins. Sialoglycans, the products sialylation, are located on outmost cells and participate in pivotal biological processes. They have been identified as glyco-immune checkpoints currently under rigorous investigation field tumor research. It noteworthy that exploration sialoglycans pregnancy contexts was both initiated 1960s. Mechanisms these two conditions exhibit similarities. Trophoblast infiltration during gets controlled, while invasion uncontrolled. The maternal-fetal immunotolerance balances acceptance semiallogeneic fetus resistance against "non-self" antigen attack simultaneously. Tumors mask themselves with "don't eat me" signals to escape immune surveillance. trophoblastic epithelium covered sialoglycans, demonstrated play an regulatory role throughout entire pregnancy. Immune abnormalities commonly recognized important reason for miscarriages. Therapeutic strategies desialylation targeting receptors studied tumors, agents target not Thus, investigating roles their intersection tumors may facilitate development novel therapies treatment pregnancy-related diseases, such miscarriage preeclampsia.

Language: Английский

From mechanism to therapy: the journey of CD24 in cancer DOI Creative Commons
Kai Zhao,

Caifeng Wu,

Xiangjun Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 31, 2024

CD24 is a glycosylphosphatidylinositol-anchored protein that expressed in wide range of tissues and cell types. It involved variety physiological pathological processes, including adhesion, migration, differentiation, apoptosis. Additionally, has been studied extensively the context cancer, where it found to play role tumor growth, invasion, metastasis. In recent years, there growing interest as potential therapeutic target for cancer treatment. This review summarizes current knowledge CD24, its structure, function, cancer. Finally, we provide insights into clinical application discuss possible approaches development targeted therapies.

Language: Английский

Citations

6
A Dual Enhancing Strategy of Novel Nanovaccine Based on TIM3 Silencing Nanoadjuvants and Desialylated Cancer Cell Membrane Antigens for Personalized Vaccination Immunotherapy of Cancer DOI
Kaiming Li, Xiaolin Li, Jie Wu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Abstract Cancer vaccines represent a promising form of immunotherapy employed in the treatment cancer. However, their efficiency eliciting immune responses is limited, and satisfactory results have yet to be achieved. Optimizing adjuvants antigens an important approach promoting anti‐tumor efficacy cancer vaccines. Here, novel nanoadjuvant (LNP/siRNA) designed silence T‐cell immunoglobulin mucin‐domain containing‐3 (TIM3) activate Toll‐like receptors (TLRs) presented. The LNP/siRNA demonstrates significant potential dendritic cell (DC) maturation enhancing response. Furthermore, desialylated membrane utilized as antigens, providing variety tumor for DCs function. Additionally, they are integrated create core‐shell structured nanovaccine (dClip‐LNP/siRNA) through coextrusion, which collectively enhances cross‐presentation ability DCs, thus achieving dual enhancement strategy. dClip‐LNP/siRNA significantly silences TIM3 expression promotes antigen presentation by DCs. Besides, activation T cells lymph nodes induces robust durable immunity sites eliminate established B16‐OVA tumors, prevent occurrence, suppress lung metastasis. also suitable combination with adoptive OT‐I therapy enhance immunotherapy. represents vaccine platform personalized

Language: Английский

Citations

4
Insights on the Role of Sialic Acids in Acute Lymphoblastic Leukemia in Children DOI Open Access
Kimberley Rinai Radu, Kwang‐Hyun Baek

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2233 - 2233

Published: March 1, 2025

Sialic acids serve as crucial terminal sugars on glycoproteins or glycolipids present cell surfaces. These are involved in diverse physiological and pathological processes through their interactions with carbohydrate-binding proteins, facilitating cell-cell communication influencing the outcomes of bacterial viral infections. The role hypersialylation tumor growth metastasis has been widely studied. Recent research highlighted significance aberrant sialylation enabling cells to escape immune surveillance sustain malignant behavior. Acute lymphoblastic leukemia (ALL) is a heterogenous hematological malignancy that primarily affects children second leading cause mortality among individuals aged 1 14. ALL characterized by uncontrolled proliferation immature lymphoid bone marrow, peripheral blood, various organs. acid-binding immunoglobulin-like lectins (Siglecs) surface proteins can bind sialic acids. Activation Siglecs triggers downstream reactions, including induction apoptosis. Siglec-7 Siglec-9 have reported promote cancer progression driving macrophage polarization, expressions natural killer inhibit death. This comprehensive review aims explore mechanisms effects children. Understanding complex interplay between holds great potential for developing novel diagnostic tools therapeutic interventions managing this pediatric malignancy.

Language: Английский

Citations

0
Multi-targeted olink proteomics analyses of cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage DOI Creative Commons
Rui Ding,

Liquan Wu,

Shanshan Wei

et al.

Proteome Science, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 27, 2024

The complexity of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) may require the simultaneous analysis variant types protein biomarkers to describe it more accurately. In this study, we analyzed for first time alterations cerebrospinal fluid (CSF) proteins in patients with aSAH by multi-targeted Olink proteomics, aiming reveal pathophysiology DCI and provide insights into diagnosis treatment aSAH. Six six control were selected, CSF samples Proteomics (including 96-neurology panel 96-inflammation panel) based on Proximity Extension Assay (PEA). Differentially expressed (DEPs) acquired bioinformatics was performed. PCA revealed better intra- inter-group reproducibility groups. 23 neurology-related 31 inflammation-relevant differential identified. neurology panel, compared controls, up-regulated SAH predominantly included macrophage scavenger receptor 1 (MSR1), siglec-1, siglec-9, cathepsin C (CTSC), S (CTSS), etc. Meanwhile, inflammation group, incremental mainly contained interleukin-6 (IL-6), MCP-1, CXCL10, CXCL-9, TRAIL, Cluster exhibited significant differences between two GO function enrichment hinted that pertinent involved regulation defense response, vesicle-mediated transport immune response; while related largely connected cellular response chemokine, chemokine chemokine-mediated signaling pathway. Additionally, KEGG indicated significantly enriched phagosome, apoptosis microRNAs cancer And pathway, viral interaction cytokine toll-like These identified unique pathophysiological characteristics secondary Further characterization these aberrant pathways future research could enable their application as potential therapeutic targets

Language: Английский

Citations

1
Mechanistic and Therapeutic Implications of Protein and Lipid Sialylation in Human Diseases DOI Open Access
Xiaotian Zhong, Aaron M. D’Antona, Jason C. Rouse

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11962 - 11962

Published: Nov. 7, 2024

Glycan structures of glycoproteins and glycolipids on the surface glycocalyx luminal sugar layers intracellular membrane compartments in human cells constitute a key interface between biological processes external environments. Sialic acids, class alpha-keto acid sugars with nine-carbon backbone, are frequently found as terminal residues these glycoconjugates, forming critical components layers. Changes status content cellular sialic acids closely linked to many diseases such cancer, cardiovascular, neurological, inflammatory, infectious, lysosomal storage diseases. The molecular machineries responsible for biosynthesis sialylated glycans, along their interacting partners, important therapeutic strategies targets drug development. purpose this article is comprehensively review recent literature provide new scientific insights into mechanisms implications sialylation across various Recent advances clinical developments acid-related therapies also summarized discussed.

Language: Английский

Citations

0
Unveiling sialoglycans’ immune mastery in pregnancy and their intersection with tumor biology DOI Creative Commons
Jianmei Huang, Feng Lu, Jianming Huang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 20, 2024

Sialylation is a typical final step of glycosylation, which prevalent post-translational modification proteins. Sialoglycans, the products sialylation, are located on outmost cells and participate in pivotal biological processes. They have been identified as glyco-immune checkpoints currently under rigorous investigation field tumor research. It noteworthy that exploration sialoglycans pregnancy contexts was both initiated 1960s. Mechanisms these two conditions exhibit similarities. Trophoblast infiltration during gets controlled, while invasion uncontrolled. The maternal-fetal immunotolerance balances acceptance semiallogeneic fetus resistance against "non-self" antigen attack simultaneously. Tumors mask themselves with "don't eat me" signals to escape immune surveillance. trophoblastic epithelium covered sialoglycans, demonstrated play an regulatory role throughout entire pregnancy. Immune abnormalities commonly recognized important reason for miscarriages. Therapeutic strategies desialylation targeting receptors studied tumors, agents target not Thus, investigating roles their intersection tumors may facilitate development novel therapies treatment pregnancy-related diseases, such miscarriage preeclampsia.

Language: Английский

Citations

0