Role Of Acute Vascular Distress Syndrome In The Development Of Multisystem Inflammatory Syndrome In Sars-Cov-2 And Modern Views On The Research And Treatment Of Critical Coronavirus DOI Creative Commons
Irina Vasilieva, Maria Vasilieva, Ilie Vasiliev

et al.

Special journal of the Medical Academy and other Life Sciences, Journal Year: 2024, Volume and Issue: 2(4)

Published: May 22, 2024

Background: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the complex pathology of virus, which extends beyond respiratory symptoms to include multisystem inflammatory syndrome (MIS). This review explores role Acute Vascular Distress Syndrome (AVDS) in development MIS both adults (MIS-A) and children (MIS-C), providing a comprehensive overview modern research treatment approaches for severe coronavirus infections. Methods Materials: synthesizes findings from multiple studies clinical reports analyze mechanisms SARS-CoV-2 induces AVDS subsequently MIS. Key materials molecular cellular data, case studies, protocols. Diagnostic tools such as PCR serological testing, well various biomarkers like neurofilament light chain galectin-3, are discussed elucidate their roles identifying managing cases. Results: interaction between host endothelial cells, mediated ACE2 receptors, triggers cascade responses leading AVDS. is characterized dysfunction, cytokine storms, mitochondrial distress, collectively contribute pathogenesis Clinical evidence indicates that critical factor severity COVID-19, with widespread implications organ systems, including central peripheral nervous systems. Conclusion: Understanding offers valuable insights into pathophysiology COVID-19. Effective management requires multifaceted approach, combining antiviral therapies, immunomodulators, supportive treatments extracorporeal membrane oxygenation (ECMO). Future should focus on targeted therapies mitigate damage improve patient outcomes

Language: Английский

Inhibition of MERS-CoV papain-like protease by sunitinib: In vitro and in silico investigations DOI Creative Commons

Ahmed L. Alaofi,

Mudassar Shahid, Mohd Abul Kalam

et al.

Pharmacia, Journal Year: 2025, Volume and Issue: 72, P. 1 - 12

Published: April 4, 2025

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) remains a significant public health threat, with high mortality rates and no approved antiviral therapies. The papain-like protease (PLpro) of MERS-CoV plays critical role in viral replication immune evasion, making it key target for drug discovery. This study evaluated the inhibitory effects four anticancer drugs (sunitinib, olaparib, mitoxantrone, bicalutamide) on recombinant MERS-CoVPLpro using combination vitro silico techniques. Protease inhibition assays revealed that sunitinib displayed potent, dose-dependent PLpro activity, an IC 50 1.75 µM, while bicalutamide exhibited negligible inhibition. Thermal shift confirmed strong interaction PLpro, showing ΔTm 26.64 °C, indicative increased protein stability. Furthermore, molecular dynamics (MD) simulations docking studies provided structural insights into mechanism Sunitinib bound within thumb domain forming stable interactions residues such as D76, R82, F79. Binding induced stabilization PLpro’s structure, reducing flexibility regions, including catalytic domains, indicated by decreased radius gyration alterations free energy landscape. Importantly, was consistent between analyses, highlighting its robust potential. These findings position promising inhibitor MERS-CoVPLpro, binding affinity ability to disrupt enzymatic function. Further preclinical are warranted explore therapeutic potential against MERS-CoV. underscores utility repurposing existing emerging threats contributes development targeted strategies.

Language: Английский

Citations

0
Advances in the understanding of androgen receptor structure and function and in the development of next-generation AR-targeted therapeutics DOI

Wendy Effah,

Marjana Khalil,

Dong‐Jin Hwang

et al.

Steroids, Journal Year: 2024, Volume and Issue: 210, P. 109486 - 109486

Published: Aug. 5, 2024

Language: Английский

Citations

2
The Toxic Effects on the Testis of Flutamide vs. Bicalutamide vs. Cyproterone Acetate: an Experimental Rat Study DOI Creative Commons

Metin Gür,

Eyüp Dil, Ekrem Akdeniz

et al.

New Trends in Medicine Sciences, Journal Year: 2024, Volume and Issue: 5(2), P. 84 - 90

Published: May 27, 2024

The aim of this study was to investigate the toxic effects on rat testis flutamide, bicalutamide, and cyproterone acetate using histopathological methods. Twenty-four male Sprague-Dawley rats were randomly divided into four groups, control (Group 1), flutamide 2), bicalutamide 3), 4). Physiological saline solution or anti-androgens administered via oral gavage for 14 days. At end study, testes harvested histological effect scoring. mean histopathology scores 0 in Group 1, 0.33 ± 0.81 2, 1.66 1.36 3, 2.93 0.98 4. score 4 significantly higher than that 1 (p = 0.002), but not different those groups 2 3 0.317 p 0.028, respectively). No significant difference also observed between other groups. Cyproterone acetate, a steroidal antiandrogen, resulted impairment histology relative non-steroidal antiandrogens bicalutamide. A agent such as should therefore be selected if antiandrogen therapy is initiated reasons acne, hirsutism, paraphilias, particularly young males.

Language: Английский

Citations

1
Update on andrological effects of SARS‐CoV‐2 infection and COVID‐19: An overview review DOI Creative Commons
Giuseppe Lisco, Anna De Tullio, Maima Matin

et al.

Andrology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Evidence indicates a wide range of andrological alterations in patients with the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection and Coronavirus Disease 2019 (COVID-19).

Language: Английский

Citations

1
Role Of Acute Vascular Distress Syndrome In The Development Of Multisystem Inflammatory Syndrome In Sars-Cov-2 And Modern Views On The Research And Treatment Of Critical Coronavirus DOI Creative Commons
Irina Vasilieva, Maria Vasilieva, Ilie Vasiliev

et al.

Special journal of the Medical Academy and other Life Sciences, Journal Year: 2024, Volume and Issue: 2(4)

Published: May 22, 2024

Background: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the complex pathology of virus, which extends beyond respiratory symptoms to include multisystem inflammatory syndrome (MIS). This review explores role Acute Vascular Distress Syndrome (AVDS) in development MIS both adults (MIS-A) and children (MIS-C), providing a comprehensive overview modern research treatment approaches for severe coronavirus infections. Methods Materials: synthesizes findings from multiple studies clinical reports analyze mechanisms SARS-CoV-2 induces AVDS subsequently MIS. Key materials molecular cellular data, case studies, protocols. Diagnostic tools such as PCR serological testing, well various biomarkers like neurofilament light chain galectin-3, are discussed elucidate their roles identifying managing cases. Results: interaction between host endothelial cells, mediated ACE2 receptors, triggers cascade responses leading AVDS. is characterized dysfunction, cytokine storms, mitochondrial distress, collectively contribute pathogenesis Clinical evidence indicates that critical factor severity COVID-19, with widespread implications organ systems, including central peripheral nervous systems. Conclusion: Understanding offers valuable insights into pathophysiology COVID-19. Effective management requires multifaceted approach, combining antiviral therapies, immunomodulators, supportive treatments extracorporeal membrane oxygenation (ECMO). Future should focus on targeted therapies mitigate damage improve patient outcomes

Language: Английский

Citations

0