Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: June 12, 2024
Lipids, the primary constituents of cell membrane, play essential roles in nearly all cellular functions, such as cell-cell recognition, signaling transduction, and energy provision. Lipid metabolism is necessary for maintenance life since it regulates balance between processes synthesis breakdown. Increasing evidence suggests that cancer cells exhibit abnormal lipid metabolism, significantly affecting their malignant characteristics, including self-renewal, differentiation, invasion, metastasis, drug sensitivity resistance. Prominent oncogenic pathways modulate metabolic gene expression elevate enzyme activity include phosphoinositide 3-kinase (PI3K)/AKT, MAPK, NF-kB, Wnt, Notch, Hippo pathway. Conversely, when are not regulated, they can lead to malfunctions signal transduction pathways. This, turn, enables uncontrolled growth by providing energy, building blocks, redox potentials. Therefore, targeting metabolism-associated could be an effective therapeutic approach decrease incidence promote survival. This review sheds light on interactions reprogramming cancer. Exploring a target provide promising creating anticancer treatments identifying inhibitors. Additionally, we have also provided overview drugs this review.
Language: Английский
Citations
6
Cells, Journal Year: 2024, Volume and Issue: 13(18), P. 1574 - 1574
Published: Sept. 19, 2024
Glioblastoma (GBM) is an aggressive and highly malignant primary brain tumor characterized by rapid growth a poor prognosis for patients. Despite advancements in treatment, the median survival time GBM patients remains low. One of crucial challenges understanding treating GBMs involves its remarkable cellular heterogeneity adaptability. Central to proliferation cells their ability undergo metabolic reprogramming. Metabolic reprogramming process that allows cancer alter metabolism meet increased demands survive often oxygen- nutrient-deficient microenvironment. These changes include Warburg effect, alterations several key pathways including glutamine metabolism, fatty acid synthesis, tricarboxylic (TCA) cycle, uptake utilization glutamine, more. complexity adaptability deeper offers hope developing more effective therapeutic interventions against GBMs.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1875 - 1875
Published: Feb. 21, 2025
Glioblastoma (GBM) is the most aggressive primary brain cancer, with poor prognosis due to its behavior and high heterogeneity. This study aimed identify cellular senescence (CS) lipid metabolism (LM)-related prognostic genes improve GBM treatment. Transcriptome scRNA-seq data, CS-associated (CSAGs), LM-related (LMRGs) were acquired from public databases. Prognostic identified by intersecting CSAGs, LMRGs, differentially expressed (DEGs), followed WGCNA univariate Cox regression. A risk model nomogram constructed. Analyses covered clinicopathological features, immune microenvironment, somatic mutations, drug sensitivity. data key cells gene expression. SOCS1 PHB2 as markers, contributing construction of a robust excellent predictive ability. High-risk group (HRG) patients had poorer survival, higher stromal scores, distinct mutation profiles. Drug sensitivity analysis revealed significant differences in IC50 values. In microglia differentiation, showed dynamic expression patterns. These findings provide new strategies for
Language: Английский
Citations
0
Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: March 17, 2025
Abstract Glioblastoma is a highly malignant tumor of the central nervous system with high mortality rate. The mechanisms driving glioblastoma onset and progression are complex, posing substantial challenges for developing precise therapeutic interventions to improve patient survival. Over century ago, discovery Warburg effect underscored importance abnormal glycolysis in tumors, marking pivotal moment cancer research. Subsequent studies have identified mitochondrial energy conversion as fundamental driver growth. Recently, lipid metabolism has emerged critical factor cell survival, providing an alternative source. Research shown that reprogrammed glioblastoma, playing vital role shaping biological behavior cells. In this review, we aim elucidate impact on tumorigenesis explore potential targets. Additionally, provide insights into regulatory govern metabolism, emphasizing roles key genes regulators involved essential metabolic process.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 28, 2025
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, characterized by rapid proliferation, extensive infiltration, significant intratumoral heterogeneity. Despite advancements conventional treatments, including surgery, radiotherapy, chemotherapy, prognosis for GBM patients remains poor, with a median survival of approximately 15 months. Immunotherapy has emerged as promising alternative; however, unique biological immunological features, its immunosuppressive microenvironment (TME) low mutational burden, render it resistant to many immunotherapeutic strategies. This review explores key challenges immunotherapy, focusing on immune evasion mechanisms, blood-brain barrier (BBB), TME. Immune checkpoint inhibitors CAR-T cells have shown promise preclinical models but limited clinical success due antigen heterogeneity, cell exhaustion, impaired trafficking across BBB. Emerging strategies, dual-targeting cells, engineered secreting therapeutic molecules, advanced delivery systems overcome BBB, show potential enhancing treatment efficacy. Addressing these crucial improving immunotherapy outcomes.
Language: Английский
Citations
0
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: May 13, 2024
Language: Английский
Citations
0
Published: May 22, 2024
Citations
0