Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1581 - 1581
Published: Dec. 11, 2024
Immunotherapy
has
shown
significant
improvement
in
the
survival
of
patients
with
hepatocellular
carcinoma
(HCC)
compared
to
TKIs
as
first-line
treatment.
Unfortunately,
approximately
30%
HCC
exhibits
intrinsic
resistance
ICIs,
making
new
therapeutic
combinations
urgently
needed.
The
dysregulation
Notch
signaling
pathway
observed
can
affect
immune
cell
response,
reducing
efficacy
cancer
immunotherapy.
Here,
we
provide
an
overview
how
regulates
responses
and
present
rationale
for
combining
inhibition
ICIs
improve
Moreover,
propose
using
exosomes
non-invasive
tools
assess
activation
hepatic
cells,
enabling
accurate
stratification
who
benefit
from
combined
strategies.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(2), P. 314 - 314
Published: Jan. 7, 2025
Transcatheter
arterial
chemoembolization
(TACE)
is
a
proven
and
widely
accepted
treatment
option
for
hepatocellular
carcinoma
it
recommended
as
first-line
non-curative
therapy
BCLC
B/intermediate
HCC
(preserved
liver
function,
multifocal,
no
cancer-related
symptoms)
in
patients
without
vascular
involvement.
Different
types
of
TACE
are
available
nowadays,
including
TAE,
c-TACE,
DEB-TACE,
DSM-TACE,
but
at
present
there
insufficient
evidence
to
recommend
one
technique
over
another
the
choice
left
operator.
This
review
then
aims
provide
comprehensive
overview
current
literature
on
indications,
procedures,
safety,
efficacy
different
treatments.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 24, 2025
Background
Hepatocellular
carcinoma
(HCC)
and
cholangiocarcinoma
(CCA)
represent
the
primary
liver
cancer
types.
Traditional
diagnostic
techniques,
reliant
on
radiologist
interpretation,
are
both
time-intensive
often
inadequate
for
detecting
less
prevalent
CCA.
There
is
an
emergent
need
to
explore
automated
methods
using
deep
learning
address
these
challenges.
Methods
This
study
introduces
HTRecNet,
a
novel
framework
enhanced
precision
efficiency.
The
model
incorporates
sophisticated
data
augmentation
strategies
optimize
feature
extraction,
ensuring
robust
performance
even
with
constrained
sample
sizes.
A
comprehensive
dataset
of
5,432
histopathological
images
was
divided
into
5,096
training
validation,
336
external
testing.
Evaluation
conducted
five-fold
cross-validation
applying
metrics
such
as
accuracy,
area
under
receiver
operating
characteristic
curve
(AUC),
Matthews
correlation
coefficient
(MCC)
against
established
clinical
benchmarks.
Results
validation
cohorts
comprised
1,536
normal
tissue,
3,380
HCC,
180
HTRecNet
showed
exceptional
efficacy,
consistently
achieving
AUC
values
over
0.99
across
all
categories.
In
testing,
reached
accuracy
0.97
MCC
0.95,
affirming
its
reliability
in
distinguishing
between
normal,
CCA
tissues.
Conclusion
markedly
enhances
capability
early
accurate
differentiation
HCC
from
Its
high
efficiency
position
it
invaluable
tool
settings,
potentially
transforming
protocols.
system
offers
substantial
support
refining
workflows
healthcare
environments
focused
malignancies.
Free Radical Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 12
Published: March 25, 2025
Hepatocellular
carcinoma
(HCC)
is
a
common
and
deadly
form
of
liver
cancer
with
limited
treatment
options
for
advanced
stages.
Mesoionic
compounds
MI-D
MI-J
have
shown
potential
treating
HCC
due
to
their
significant
toxicity
these
cells.
This
study
investigated
whether
this
linked
effects
on
oxidative
balance
in
HepG2
cells
cultured
high
glucose
(HG-glycolysis-dependent)
galactose
plus
glutamine
supplemented
(GAL-
phosphorylation-dependent)
DMEM
medium.
ROS
levels
were
increased
both
media
when
exposed
(50
μM).
However,
at
an
intermediate
concentration
(25
μM)
decreased
the
GAL
Superoxide
dismutase
(SOD)
activity
under
all
tested
conditions
by
Conversely,
total
peroxidase
25
50
μM,
respectively.
HG
medium
glutathione
(GPX)
activity,
whereas
reduced
enzyme
μM
it
μM.
In
medium,
GPx
while
reductase
(GR)
was
media.
Furthermore,
P-AMPK/tAMPk
ratio
Our
results
show
that
caused
imbalance,
particularly
affecting
The
data
also
support
mesoionic
depended
substituent
ring.
