The hepatocellular model of fatty liver disease: from current imaging diagnostics to innovative proteomics technologies

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 5, 2025

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a prevalent chronic liver condition characterized by lipid accumulation and inflammation, often progressing to severe damage. We aim review the pathophysiology, diagnostics, clinical care of MASLD, highlights advances in proteomic technologies. Recent proteomics technologies have improved identification novel biomarkers therapeutic targets, offering insight into molecular mechanisms underlying MASLD progression. focus on application mass spectrometry-based including single cell proteomics, proteogenomics, extracellular vesicle (EV-omics), exposomics for biomarker discovery, emphasizing potential blood-based panels noninvasive diagnosis personalized medicine. Future research directions are presented develop targeted therapies improve outcomes patients.

Language: Английский

Advancing cancer therapeutics: Integrating scalable 3D cancer models, extracellular vesicles, and omics for enhanced therapy efficacy

Advances in cancer research, Journal Year: 2024, Volume and Issue: unknown, P. 137 - 185

Published: Jan. 1, 2024

Language: Английский

Exosomes and tissue engineering: A novel therapeutic strategy for nerve regenerative

Tissue and Cell, Journal Year: 2024, Volume and Issue: 93, P. 102676 - 102676

Published: Dec. 13, 2024

Language: Английский