Towards Aptamer-Targeted Drug Delivery to Brain Tumors: The Synthesis of Ramified Conjugates of an EGFR-Specific Aptamer with MMAE on a Cathepsin B-Cleavable Linker DOI Creative Commons
Vladimir A. Brylev, Ekaterina V. Ryabukhina, Evgeniya V. Nazarova

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1434 - 1434

Published: Nov. 11, 2024

Targeted delivery of chemotherapeutic agents is a well-established approach to cancer therapy. Antibody-drug conjugates (ADCs) typically carry toxic payloads attached tumor-associated antigen-targeting IgG antibody via an enzyme-cleavable linker that releases the drug inside cell. Aptamers are promising alternative antibodies in terms antigen targeting; however, their polynucleotide nature and smaller size result completely different PK/PD profile compared IgG. This may prove advantageous: owing lower molecular weight, aptamer-drug achieve better penetration solid tumors ADCs.

Language: Английский

Generation and characterization of 7DC-DM1: a non-cleavable CD47-targeting antibody-drug conjugates with antitumor effects DOI

Zu-Chian Chiang,

Shan Xu,

Xiangqian Zhao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142844 - 142844

Published: April 1, 2025

Language: Английский

Citations

0
Targeting Non-histone Methylation in Gastrointestinal Cancers: From biology to clinic DOI
Zhanbo Sun,

Lixian Liu,

Jun Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 278, P. 116802 - 116802

Published: Aug. 26, 2024

Language: Английский

Citations

0
Amitriptyline nanoparticle repositioning prolongs the anti-allodynic effect of enhanced microglia targeting DOI
Song I Kim,

Jiah Yang,

Juhee Shin

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(25), P. 2099 - 2112

Published: Sept. 4, 2024

Amitriptyline (AMI) has been used to treat neuropathic pain. However, the clinical outcomes remain unsatisfactory, presumably due a limited understanding of underlying molecular mechanisms. Here, we investigated drug repositioning strategy using low-dose AMI encapsulated in poly (D, L lactic-co-glycolic acid) (PLGA) nanoparticles (AMI NPs) for pain, since PLGA are known enhance delivery microglia.

Language: Английский

Citations

0
Towards Aptamer-Targeted Drug Delivery to Brain Tumors: The Synthesis of Ramified Conjugates of an EGFR-Specific Aptamer with MMAE on a Cathepsin B-Cleavable Linker DOI Creative Commons
Vladimir A. Brylev, Ekaterina V. Ryabukhina, Evgeniya V. Nazarova

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1434 - 1434

Published: Nov. 11, 2024

Targeted delivery of chemotherapeutic agents is a well-established approach to cancer therapy. Antibody-drug conjugates (ADCs) typically carry toxic payloads attached tumor-associated antigen-targeting IgG antibody via an enzyme-cleavable linker that releases the drug inside cell. Aptamers are promising alternative antibodies in terms antigen targeting; however, their polynucleotide nature and smaller size result completely different PK/PD profile compared IgG. This may prove advantageous: owing lower molecular weight, aptamer-drug achieve better penetration solid tumors ADCs.

Language: Английский

Citations

0