Application of Nanocarrier Systems in Cancer Treatment

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Unraveling the interplay: exploring signaling pathways in pancreatic cancer in the context of pancreatic embryogenesis

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 22, 2024

Pancreatic cancer continues to be a deadly disease because of its delayed diagnosis and aggressive tumor biology. Oncogenes risk factors are being reported influence the signaling pathways involved in pancreatic embryogenesis leading genesis. Although studies using rodent models have yielded insightful information, scarcity human tissue has made it difficult comprehend how pancreas develops. Transcription like IPF1/ PDX1 , HLXB9, PBX1, MEIS Islet-1, pathways, including Hedgehog, TGF-β, Notch, directing organogenesis. Any derangements above may lead cancer. TP53 : CDKN2A suppressor genes, mutations somatic loss drivers This review clarifies complex mechanism cancer, same development, current therapeutic approach targeting molecules, action promoting

Language: Английский

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Multicomponent nanosystem for capturing circulating tumor cells from cancer patients with PD-L1 as an immunotherapy oncotarget

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

OncoDiscover® is a novel platform for the capture of rare circulating tumor cells from cancer patients in presence PD-L1 oncotarget. It being used routinely clinic prognosis to improve overall survival patients.

Language: Английский

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Folic Acid-Targeted Mixed Pluronic Micelles for Delivery of Triptolide

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3485 - 3485

Published: Dec. 13, 2024

The present study aimed to explore an ideal delivery system for triptolide (TPL) by utilizing the thin-film hydration method prepare drug-loaded, folate-modified mixed pluronic micelles (FA–F-127/F-68–TPL). Scanning electron microscopy and atomic force showed that drug-loaded had a spherical shape with small particle size, average of 30.7 nm. Cell viability experiments FA–F-127/F-68–TPL significantly reduced HepG2 cell viability, exhibiting strong cytotoxicity. Its cytotoxicity was markedly enhanced compared bare TPL. Nile red (Nr) used as model drug FA–F-127/F-68–Nr further validate its tumor-targeting cellular uptake capability. After coincubation cells, multifunctional microplate reader intracellular fluorescence intensity increased, indicating could more effectively enter cells. A nude mouse subcutaneous hepatocellular carcinoma constructed. Following tail vein injection FA–F-127/F-68–Nr, imaging FA–F127/F-68–Nr target tumor tissue, even if entering small-sized challenging, it be excreted through urine. Nude mice were treated injections (45 µg/kg) every other day 21 days. results growth transplanted tumors slowed, no significant difference In summary, exhibits advantages low cost, excellent biological properties, active/passive targeting capabilities, notable against liver cancer inhibition growth. Significantly, FA–F-127/F-68–TPL, despite challenges in insignificant EPR effect, can efficiently via kidneys, thereby preventing release during prolonged circulation potential damage normal tissues. Therefore, represents promising antitumor system.

Language: Английский

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Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Dec. 24, 2024

Language: Английский

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