Amplified Cell Cycle Genes Identified in High-Grade Serous Ovarian Cancer

Cancers, Journal Year: 2024, Volume and Issue: 16(16), P. 2783 - 2783

Published: Aug. 7, 2024

The objective of this study was to identify differentially expressed genes and their potential influence on the carcinogenesis serous-type ovarian cancer tumors. Serous is an epithelial subtype most common type cancer. Transcriptomic profiles serous non-cancerous datasets were obtained from Gene Expression Omnibus (GEO-NCBI). Differentially then derived those profiles; identified consistently upregulated in three or more transcriptomic profiles. These considered as gene set for further study. evaluated ontological functional analysis using Molecular Signatures Database. Next, we examined mutational impact profile high-grade (HGSO) adenocarcinoma cBioPortal database. Results OncoPrint revealed that 26 amplified than 5% HGSO patients. Interestingly, several these are involved cell cycle processes, including ATPase family AAA domain containing 2 (ATAD2), recQ-like helicase 4 (RECQL4), cyclin E1 (CCNE1), anti-silencing function 1B histone chaperone (ASF1B), ribonuclease H2 subunit A (RNASEH2A), structural maintenance chromosome (SMC4), division associated 20 (CDC20), 8 (CDCA8). receiver operating characteristic (ROC) curve results also higher specificity sensitivity Furthermore, may affect recurrence carcinogenesis. Overall, our analytical identifies cycle-related can potentially be targeted diagnostic prognostic markers

Language: Английский

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The transcriptional dysregulation of choline catabolism genes was implicated in HCC stage-specific carcinogenesis

Genome Instability & Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

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Integrating genetic and gene expression data in network-based stratification analysis of cancers

BMC Bioinformatics, Journal Year: 2025, Volume and Issue: 26(1)

Published: May 13, 2025

Cancers are complex diseases that have heterogeneous genetic drivers and varying clinical outcomes. A critical area of cancer research is organizing patient cohorts into subtypes associating with biological outcomes for more effective prognosis treatment. Large-scale studies collected a plethora omics data across multiple tumor types, providing an extensive dataset stratifying cohorts. Network-based stratification (NBS) approaches been presented to classify tumors using somatic mutation data. challenge in integrating yield clinically meaningful subtypes. In this study, we investigate novel approach the NBS framework by RNA sequencing investigating effectiveness integrated on three cancers: ovarian, bladder, uterine cancer. We show significantly associated overall survival or histology. Specifically, observe ovarian bladder were than single-data type subtypes, even when accounting covariates. addition, histology Integrated networks also reveal highly influential genes span subtype-specific genes. Pathway enrichment analysis overarching differences between These pathways involved set cell functions, including ubiquitin homeostasis, p53 regulation, cytokine chemokine signaling, proliferation, emphasizing importance identifying not only cancer-specific gene but drivers. Our study highlights significance multi-omics within enhance subtyping, specifically its utility offering profound implications personalized treatment strategies. insights contribute ongoing advancement computational subtyping methods uncover targeted therapeutic treatments while facilitating discovery driver

Language: Английский

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A Case Report to Reflect on the Origins of MMRd Mesonephric-like Ovarian Adenocarcinoma: Can It Be Defined as a Mϋllerian Neoplasm?

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(11), P. 5245 - 5245

Published: May 29, 2025

Mesonephric-like adenocarcinoma (MLA) of ovaries is a new and rare neoplastic entity, recently classified by the World Health Organization. Its morphological immunohistochemical profile similar to primitive cervical mesonephric adenocarcinoma, but its origin has not been determined yet. Some authors believe that this neoplasm originates from Wolffian remnants in ovarian hilum, while others suggest an Mϋllerian epithelium, followed trans-differentiation. Starting diagnosed mismatch repair-deficient MLA, we try further develop line research. A detailed molecular analysis studied tumor helps clarify our ideas. In fact, typical KRAS mutation was present. We found mutations numerous other genes, which are rarely described literature or already endometrioid histotype. reached some interesting conclusions, which, if supported future studies, will true nature these tumors, allowing for better stratification therapeutic framework.

Language: Английский

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Diffuse subtype-specific gastric carcinogenesis associated with dysregulation of Notch signaling pathways

Genome Instability & Disease, Journal Year: 2024, Volume and Issue: 5(3), P. 116 - 126

Published: June 14, 2024

Language: Английский

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