A two-step, two-sample Mendelian randomization analysis investigating the interplay between gut microbiota, immune cells, and melanoma skin cancer DOI Creative Commons
Jiaqi Lou,

Ziyi Xiang,

Xiaoyu Zhu

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(45), P. e40432 - e40432

Published: Nov. 8, 2024

This study aims to rigorously explore the potential causal relationships among gut microbiota (GM), immune cells, and melanoma skin cancer participants from Europe, where this disease exhibits significant prevalence profound societal impact. Using genome-wide association analysis database, a double-sample Mendelian randomization (MR) was drawn upon investigate GM, cancer. The inverse variance weighted approach applied estimate connections these variables. A two-step MR employed quantitatively gauge impact of cells mediated GM on To address sources bias, such as pleiotropy heterogeneity, multiple analytical techniques were integrated. pinpointed 6 taxa related either an augmented or declined risk late-stage In same vein, 32 cell phenotypes noticed correlates with modified Our also implies that probable between could be facilitated by 5 phenotypes. findings our underline certain influencers onset development Importantly, results spotlight agents mediating association.

Language: Английский

Microbiota and Cytokine Modulation: Innovations in Enhancing Anticancer Immunity and Personalized Cancer Therapies DOI Creative Commons

Hamidreza Farhadi Rad,

Hamed Tahmasebi,

Samaneh Javani

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2776 - 2776

Published: Dec. 6, 2024

The gut microbiota plays a crucial role in modulating anticancer immunity, significantly impacting the effectiveness of various cancer therapies, including immunotherapy, chemotherapy, and radiotherapy. Its impact on development is complex; certain bacteria, like

Language: Английский

Citations

4
The benefits of Lactiplantibacillus plantarum: from immunomodulator to vaccine vector DOI Creative Commons
Joshua Tobias,

Stefan Heinl,

Kristina Dendinovic

et al.

Immunology Letters, Journal Year: 2025, Volume and Issue: 272, P. 106971 - 106971

Published: Jan. 5, 2025

Probiotics have been increasingly recognized for positively influencing many aspects of human health. Lactiplantibacillus plantarum (L. plantarum), a non-pathogenic bacterium, previously known as Lactobacillus plantarum, is one the lactic acid bacteria commonly used in fermentation. The probiotic properties L. highlighted its health benefits to humans when consumed adequate amounts. strains primarily enter body orally and alter intestinal microflora modulate immune responses their host; thereby benefiting Furthermore, use vaccine vectors delivering mucosal antigens has shown be promising strategy. These aspects, from Immunomodulation delivery by preclinical settings, are this review. Along these lines, construction recombinant strain expressing B cell multi-peptide, future immunity confer anti-tumor effect targeting Her-2/neu-overexpressing cancers local distal sites, also presented discussed.

Language: Английский

Citations

0
Microbiota as diagnostic biomarkers: advancing early cancer detection and personalized therapeutic approaches through microbiome profiling DOI Creative Commons
Majid Eslami, Ramtin Naderian, Aisa Bahar

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

The important function of microbiota as therapeutic modulators and diagnostic biomarkers in cancer has been shown by recent developments microbiome research. intricate interplay between the gut development cancer, especially colorectal breast cancers, emphasizes how microbial profiling may be used for precision treatment early diagnosis. Important signatures, including Bacteroides fragilis Fusobacterium nucleatum , have linked to progression providing information on processes behind carcinogenesis. Additionally, influence effectiveness treatments such immunotherapy chemotherapy highlights its dual improving outcomes reducing side effects. To optimize results, strategies dietary changes fecal transplantation (FMT) are being investigated. Despite these developments, there still issues, individual variations composition, a lack standardized procedures, requirement reliable biomarkers. Integrating microbiome-based diagnostics with conventional approaches, liquid biopsies machine learning algorithms, could revolutionize detection management. This review provides an overview current understanding host–microbe immunological axis discusses emerging centered modulation support human health. Further research is essential overcome existing challenges fully realize promise microbiota-driven innovations oncology.

Language: Английский

Citations

0
Evidence for the evolving role of neoadjuvant and perioperative immunotherapy in resectable non-small cell lung cancer DOI Creative Commons

Thomas Fritz Hansen,

Jonathon T. Hill, Gary Tincknell

et al.

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2024, Volume and Issue: 5(6), P. 1247 - 1260

Published: Sept. 29, 2024

The treatment of early-stage non-small cell lung cancer (NSCLC) is becoming increasingly complex. Standard care management for the past decade has been adjuvant chemotherapy following curative intent resection regardless nodal status or tumour profile. With increased incorporation immunotherapy in NSCLC, especially locally advanced, unresectable, metastatic settings, multiple studies have sought to assess its utility disease. While there are suboptimal responses neoadjuvant alone, a strong rationale use downstaging, based upon concept enhanced T priming at time high antigen burden, and demonstrated clinically other solid tumours, such as melanoma. In NSCLC setting, currently over 20 combinations chemoimmunotherapy perioperative setting studied with results variable. Multiple large phase III that result significant advances pathological response, disease free overall survival which led practice change across world. Currently, combination regimens novel agents targeting alternate immunomodulatory pathways now being investigated. Given this, landscape resectable become This review outlines literature discusses potential benefits complexities ongoing considerations into future research.

Language: Английский

Citations

1
Biomarkers for immunotherapy resistance in non-small cell lung cancer DOI Creative Commons

Catriona Rother,

Thomas John, Annie Wong

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 19, 2024

Immunotherapy has revolutionised the treatment landscape of non-small cell lung cancer (NSCLC), significantly improving survival outcomes and offering renewed hope to patients with advanced disease. However, majority experience limited long-term benefits from immune checkpoint inhibition (ICI) due development primary or acquired immunotherapy resistance. Accurate predictive biomarkers for resistance are essential individualising strategies, outcomes, minimising potential treatment-related harm. This review discusses mechanisms underlying immunotherapy, addressing both cell-intrinsic cell-extrinsic processes. We summarise current utility limitations two clinically established biomarkers: programmed death ligand 1 (PD-L1) expression tumour mutational burden (TMB). Following this, we present a comprehensive emerging in NSCLC, including neoantigens, epigenetic signatures, markers microenvironment (TME), genomic alterations, host-microbiome composition, circulating biomarkers. The clinical applications these biomarkers, along novel approaches their biomarker identification targeting, discussed. Additionally, explore strategies overcome propose incorporating into an adaptive trial design, where specific signatures guide subsequent selection.

Language: Английский

Citations

1
A two-step, two-sample Mendelian randomization analysis investigating the interplay between gut microbiota, immune cells, and melanoma skin cancer DOI Creative Commons
Jiaqi Lou,

Ziyi Xiang,

Xiaoyu Zhu

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(45), P. e40432 - e40432

Published: Nov. 8, 2024

This study aims to rigorously explore the potential causal relationships among gut microbiota (GM), immune cells, and melanoma skin cancer participants from Europe, where this disease exhibits significant prevalence profound societal impact. Using genome-wide association analysis database, a double-sample Mendelian randomization (MR) was drawn upon investigate GM, cancer. The inverse variance weighted approach applied estimate connections these variables. A two-step MR employed quantitatively gauge impact of cells mediated GM on To address sources bias, such as pleiotropy heterogeneity, multiple analytical techniques were integrated. pinpointed 6 taxa related either an augmented or declined risk late-stage In same vein, 32 cell phenotypes noticed correlates with modified Our also implies that probable between could be facilitated by 5 phenotypes. findings our underline certain influencers onset development Importantly, results spotlight agents mediating association.

Language: Английский

Citations

0