Macrophages: Key Players in the Battle against Triple-Negative Breast Cancer DOI Open Access
Irena Padzińska-Pruszyńska, Paulina Kucharzewska, Agata Matejuk

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10781 - 10781

Published: Oct. 7, 2024

Triple-negative breast cancer (TNBC) is a challenging subtype of characterized by the absence estrogen and progesterone receptors HER2 expression, leading to limited treatment options poorer prognosis. TNBC particularly prevalent in premenopausal African-descent women associated with aggressive tumor behavior higher metastatic potential. Tumor-associated macrophages (TAMs) are abundantly present within microenvironment play pivotal roles promoting growth, progression, metastasis through various mechanisms, including immune suppression enhancement angiogenesis. This review provides an in-depth overview TNBC, focusing on its epidemiology, molecular characteristics, critical influence TAMs. It discusses pathological aspects that define TNBC’s nature reviews current emerging therapeutic strategies aimed at targeting these dynamics. Special attention given role TAMs, exploring their potential as targets due significant impact patient outcomes. aims highlight complexities landscape innovative approaches currently being pursued improve efficacy survival.

Language: Английский

Triple-Negative Breast Cancer Progression and Drug Resistance in the Context of Epithelial–Mesenchymal Transition DOI Open Access
Ewa Błaszczak, Paulina Miziak, Adrian Odrzywolski

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 228 - 228

Published: Jan. 12, 2025

Triple-negative breast cancer (TNBC) is one of the most difficult subtypes to treat due its distinct clinical and molecular characteristics. Patients with TNBC face a high recurrence rate, an increased risk metastasis, lower overall survival compared other subtypes. Despite advancements in targeted therapies, traditional chemotherapy (primarily using platinum compounds taxanes) continues be standard treatment for TNBC, often limited long-term efficacy. tumors are heterogeneous, displaying diverse mutation profile considerable chromosomal instability, which complicates therapeutic interventions. The development chemoresistance frequently associated process epithelial–mesenchymal transition (EMT), during epithelial tumor cells acquire mesenchymal-like phenotype. This shift enhances metastatic potential, while simultaneously reducing effectiveness chemotherapeutics. It has also been suggested that EMT plays central role stem cells. Hence, there growing interest exploring small-molecule inhibitors target as future strategy overcoming resistance improving outcomes patients TNBC. review focuses on progression drug emphasis these processes. We present TNBC-specific EMT-related features, key protein markers, various signaling pathways involved. discuss important mechanisms factors related within context EMT, highlighting improve patients’ outcomes.

Language: Английский

Citations

2
Latest Therapeutical Approaches for Triple-Negative Breast Cancer: From Preclinical to Clinical Research DOI Open Access
Mariona Pont, Marta Marqués, Anabel Sorolla

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13518 - 13518

Published: Dec. 17, 2024

Triple-negative breast cancer (TNBC) represents roughly one-sixth of all patients, but accounts for 30–40% deaths. Due to the lack typical biomarkers exploited clinically cancer, it remains very difficult treat. Moreover, its intrinsic high heterogeneity and proneness become resistant drugs administered makes treatment management challenging oncologists. Herein, we outline different therapies used currently TNBC list ongoing clinical trials provide an overview most recent therapeutic landscape. In addition, highlight emerging in preclinical stage that hold promise, such as epigenetic modulators, CRISPR, miniproteins, radioconjugates, vaccines, PROTACs. navigate through existing limitations challenges which hamper development new more effective treatments TNBC. Lastly, point directions may revolutionize future therapy

Language: Английский

Citations

4
Cellular Epigenetic Targets and Epidrugs in Breast Cancer Therapy: Mechanisms, Challenges, and Future Perspectives DOI Creative Commons

Ibrahim S. Alalhareth,

Saleh M. Alyami,

Abdulrhman Alshareef

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 207 - 207

Published: Feb. 3, 2025

Breast cancer is the most common malignancy affecting women, manifesting as a heterogeneous disease with diverse molecular characteristics and clinical presentations. Recent studies have elucidated role of epigenetic modifications in pathogenesis breast cancer, including drug resistance efflux characteristics, offering potential new diagnostic prognostic markers, treatment efficacy predictors, therapeutic agents. Key include DNA cytosine methylation covalent modification histone proteins. Unlike genetic mutations, reprogramming landscape epigenome promising targeted therapy for reversal resistance. Epidrugs, which target modifications, can provide novel options by reversing acquired to treatment. Currently, approach involves combination therapies consisting epidrugs immune checkpoint inhibitors. This review examines aberrant regulation initiation progression, focusing on related estrogen signaling, resistance, epithelial–mesenchymal transition (EMT). It existing drugs treating agents that modify DNA, inhibitors acetyltransferases, deacetylases, methyltransferases, demethyltransferases. also delves into ongoing combining other addresses upcoming obstacles this field.

Language: Английский

Citations

0
Incidência crescente de câncer de mama em mulheres entre 40 e 49 anos no Brasil (2014-2023) DOI Creative Commons
Tuany Caroline Bernardi,

Maria Luiza Paes Carpine,

Mariane Fantinelli Venarusso

et al.

Cuadernos de Educación y Desarrollo, Journal Year: 2025, Volume and Issue: 17(2), P. e7468 - e7468

Published: Feb. 6, 2025

O câncer de mama é a neoplasia maligna mais prevalente entre as mulheres globalmente, representando um desafio significativo à saúde pública. Este estudo investiga crescente incidência em jovens no Brasil 2014 e 2023, com ênfase na faixa etária 40 49 anos, historicamente excluída das diretrizes nacionais rastreamento. A análise dos dados do Sistema Informação Câncer (SISCAN) evidencia aumento substancial número mamografias realizadas, particularmente após 2020, uma recuperação observada período pós-pandêmico. Entretanto, alta proporção exames inconclusivos (BI-RADS 0) revela necessidade aprimoramentos técnicos da capacitação profissionais saúde. Os também mostram detecção carcinomas ductal in situ invasivos, além redução nos diagnósticos estágios avançados, o que sugere possível contribuição rastreamento ampliado para precoce. No entanto, crescimento tumores triplo-negativos, variante agressiva doença, ressalta urgência desenvolvimento estratégias terapêuticas eficazes. geral casos mama, associado às variações estadiamento, indica reformular os programas precoce Brasil. intensificação campanhas conscientização, ampliação acesso preventivos aprimoramento sistema registro oncológico são fundamentais oferecer compreensão detalhada cenário país.

Citations

0
Analysis of single-cell and spatial transcriptomics in TNBC cell-cell interactions DOI Creative Commons
Yan Xin,

Qiji Ma,

Qiang Deng

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Triple-negative breast cancer (TNBC) is a highly malignant tumor in women, characterized by high morbidity, mortality, and recurrence rates. Although surgical treatment, radiotherapy, chemotherapy are the mainstays of current treatment methods, heterogeneity TNBC results unsatisfactory outcomes with low 5-year survival Rapid advancements omics technology have propelled understanding molecular biology. The emergence single-cell RNA sequencing (scRNA-seq) spatial transcriptomics (ST) has significantly enhanced knowledge distribution, functionality, intercellular interactions various cell types within microenvironment, including cells, T B macrophages, fibroblasts. present study provides an overview technical characteristics scRNA-seq ST, highlighting their applications exploring heterogeneity, distribution patterns, interactions. This review aims to enhance comprehension at cellular level for development effective therapeutic targets.

Language: Английский

Citations

0
Silencing of fibronectin type III domain-containing protein 3A (FNDC3A) attenuates epithelial-to-mesenchymal transition (EMT), cancer invasion, and stemness in triple-negative breast cancer (TNBC) DOI
Noriaki Wada, Satoshi Sakai, Yasumichi Inoue

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 119935 - 119935

Published: March 1, 2025

Language: Английский

Citations

0
Gut microbiota reshapes the TNBC immune microenvironment: Emerging immunotherapeutic strategies DOI Creative Commons
Mingyao Huang, Yikai Zhang,

Zhaoji Chen

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 215, P. 107726 - 107726

Published: April 4, 2025

Triple-negative breast cancer (TNBC) is an aggressive subtype of with limited treatment options and poor prognosis. The gut microbiota, a diverse community microorganisms in the gastrointestinal tract, plays crucial role regulating immune responses through gut-immune axis. Recent studies have highlighted its significant impact on TNBC progression efficacy immunotherapies. This review examines interactions between microbiota system TNBC, focusing key cells pathways involved tumor immunity. It also explores modulation strategies, including probiotics, prebiotics, dietary interventions, fecal transplantation, as potential methods to enhance immunotherapeutic outcomes. Understanding these mechanisms offers promising avenues for improving patient prognosis TNBC.

Language: Английский

Citations

0
Impacts of Matrix Metalloproteinase-2 Promoter Genotypes on Breast Cancer Risk DOI Open Access
Chih‐Chiang Hung,

Chung‐Lin Tsai,

YU-TING CHIN

et al.

Cancer Genomics & Proteomics, Journal Year: 2024, Volume and Issue: 21(5), P. 502 - 510

Published: Aug. 27, 2024

Matrix metalloproteinase-2 (MMP-2) has been implicated in the pathogenesis of breast cancer (BC). However, there is limited research on role MMP-2 genotypes BC risk. This study aimed to investigate associations between two promoter polymorphisms, rs243865 and rs2285053,

Language: Английский

Citations

3
Hyaluronic acid application strategies for plant bioactive component delivery: A review DOI
Ailin Zhang,

John Huang,

Yutong Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137129 - 137129

Published: Oct. 31, 2024

Language: Английский

Citations

3
β-D-Glucose-Reduced Silver Nanoparticles Remodel the Tumor Microenvironment in a Murine Model of Triple-Negative Breast Cancer DOI Open Access
Pedro Félix-Piña, Moisés Ármides Franco-Molina, Paola Leonor García Coronado

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8432 - 8432

Published: Aug. 2, 2024

Breast cancer is the most diagnosed type of worldwide and second cause death in women. Triple-negative breast (TNBC) aggressive, due to lack specific targets, it considered challenging subtype treat with worst prognosis. The present study aims determine antitumor effect beta-D-glucose-reduced silver nanoparticles (AgNPs-G) a murine model TNBC, as well its on tumor microenvironment. In an airbag 4T1 cell implantation, administration AgNPs-G or doxorubicin showed antitumoral activity. Using immunohistochemistry was demonstrated that treatment decreased expression PCNA, IDO, GAL-3 increased Caspase-3. microenvironment, percentage memory T cells innate effector CD4+ regulatory cells. There also increase levels TNF-α, IFN-γ, IL-6, while TNF-α serum. conclusion, we suggest has by ability remodel microenvironment mice TNBC.

Language: Английский

Citations

1