Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention DOI Creative Commons
Elena Chitoran, Roxana Elena Bohîlțea, Vlad Rotaru

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 2013 - 2013

Published: Dec. 6, 2024

Lynch syndrome, one of the most common genetic syndromes predisposing to cancer, is associated with a series malignant conditions, among which frequent colorectal but gynecologic cancers (especially endometrial) are also quite common. Despite significant progress made in understanding this condition over time, there still aspects managing that have not demonstrated clear benefits. This article aims summarize recommendations international societies and present latest developments focusing on cancer screening possible prevention strategies. Advances testing procedures discoveries related association between oncological pathology frequency affected pathogenic variant type will probably lead personalized medicine focused individual patient coming years. Although various methods for gynecological patients syndrome been used they shown survival highlights need studying implementing new diagnostic methods, under investigation recent years mentioned article.

Language: Английский

Rheumatoid Arthritis and COVID-19 at the Intersection of Immunology and Infectious Diseases: A Related PRISMA Systematic Literature Review DOI Open Access
Andreea-Iulia Vlădulescu-Trandafir,

Violeta‐Claudia Bojincă,

Constantin Munteanu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11149 - 11149

Published: Oct. 17, 2024

Rheumatoid arthritis (RA) patients face different health challenges when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than the general population, due to both their immunocompromised state and immunosuppressive therapies they receive. This systematic literature review, which follows Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) paradigm, explores interactions between RA SARS-CoV-2 infection, focusing on immunologic issues, disease management, vaccination, adverse outcomes. In order obtain most relevant information, we systematically reviewed specific from 1 January 2021 31 December 2023, based PRISMA method, by eventually selected 35 eligible articles, added other ISI-indexed studies enrich our results further. Consequently, performed a funnel analysis evaluate potential publication bias. Firstly, data collected revealed impact of pandemic diagnoses fear face-to-face medical consultations that delayed adequate treatment. Secondly, cardiovascular metabolic comorbidities increase risk prolonged COVID-19 symptoms, hospitalization, outcomes patients. With respect treatment used control RA, it was observed glucocorticoids (especially high-dose usage) Rituximab (RTX) predispose poor outcomes, as opposed Baricitinib interleukin-6 (IL-6) tumor necrosis factor-alpha (TNF-α) inhibitors. vaccination has proven effective generally safe in some studies, although Methotrexate (MTX), Abatacept (ABA), RTX have been associated impaired vaccine immune response. review brings updated thorough information immunological, clinical, management complex immune-mediated inflammatory (IMID) like setting underlines faced this group The lessons learned can be extended beyond shaping more informed compassionate healthcare system offering long-term care RA.

Language: Английский

Citations

4
A Systematic Review and Meta-Analysis on Opioid Management of Dyspnea in Cancer Patients DOI Open Access
Elena Chitoran, Vlad Rotaru, Giuseppe Gullo

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(8), P. 1368 - 1368

Published: April 19, 2025

Background/Objectives: Dyspnea accompanies end-of-life in many cancer patients, with around 50% experiencing moderate/severe dyspnea, and is an independent factor for poor prognosis declining quality of life. Managing dyspnea becomes a key component palliative treatment support patients. Opioids seem to be the obvious choice patients as they also address pain (often important such patients). Evidence-based conclusions on effectiveness/safety opioids management are scarce, results still controversial. We aim this knowledge gap. Methods: In order achieve objective paper, we conducted comprehensive search international databases (PubMed, Medline, Embase, Cochrane Library) randomized controlled trials use treat refractory adult performed pooled meta-analysis results. Results: The effect relief was significant (SMD −0.44, 95% CI [−0.75,−0.12], p = 0.007). significance opioid maintained only morphine administration −078, [−1.45,−0.10], 0.02) exertional −1.00, [−1.98, −0.03], 0.04). No correlation noted between fentanyl/hydromorphone or administered at rest. subcutaneous route seems significantly correlated −0.73, [−1.27, −0.19], 0.008), while other modalities lack effect. present usage morphine/fentanyl increased odds severe adverse effects (OR 1.48, [0.57,3.86], 0.42); however, fentanyl associated somnolence. Although aimed evaluate how impact life were unable obtain due absolute literature available discussing QoL. Conclusions: managed provide some insights into efficiency safety evidence based low grade. There marked need gap future high-quality studies large sample sizes standardized protocols.

Language: Английский

Citations

0
Clinical and biochemical amenorrhea in premenopausal patients with breast cancer treated with chemotherapy - a prospective cohort study DOI Creative Commons
Ciniraj Raveendran,

Suma Susan Meloot,

Induprabha Yadev

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 22, 2025

Language: Английский

Citations

0
Vitamins, Coenzyme Q10, and Antioxidant Strategies to Improve Oocyte Quality in Women with Gynecological Cancers: A Comprehensive Review DOI Creative Commons

Isaic Alexandru,

Daciana Nistor, Alexandru Cătălin Motofelea

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1567 - 1567

Published: Dec. 19, 2024

Background: Gynecological cancers, including ovarian, cervical, and endometrial significantly affect both survival reproductive health in women. Cancer treatments such as chemotherapy radiotherapy can impair ovarian function, reducing oocyte quality fertility potential. Objective: This review aims to evaluate how vitamins antioxidants enhance preservation outcomes for women diagnosed with gynecological particularly the context of assisted technologies (ART). Standard these hysterectomy, bilateral salpingo-oophorectomy, radiation, chemotherapy, often compromise function quality. focuses on potential role interventions improving quality, thereby supporting successful ART outcomes. Methods: A comprehensive narrative current literature was conducted, examining effects A, C, D3, E, Coenzyme Q10 oxidative stress inflammation induced by cancer its treatments. Results: The evidence suggests that certain may mitigate damage Vitamin supports cumulus–oocyte complex integrity, while C E act potent antioxidants, tissues. D3 enhances reserve markers modulates inflammatory cytokines. improves mitochondrial reduces DNA damage, increasing viability fertilization Conclusions: incorporation specific into strategies cancers. Although preliminary findings are promising, further research is needed determine optimal dosages establish standardized protocols clinical use.

Language: Английский

Citations

2
Pelvic Exenteration in Advanced, Recurrent or Synchronous Cancers—Last Resort or Therapeutic Option? DOI Creative Commons
Vlad Rotaru, Elena Chitoran,

Daniela-Luminita Zob

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(16), P. 1707 - 1707

Published: Aug. 6, 2024

First described some 80 years ago, pelvic exenteration remain controversial interventions with variable results and ever-changing indications. The previous studies are not homogenous have different inclusion criteria (different populations disease characteristics) methodologies (including evaluation of results), making it extremely difficult to properly assess the role in cancer treatment. This study aims describe indications exenterations, main prognostic factors oncologic results, possible complications intervention.

Language: Английский

Citations

1
Cardiovascular Mortality in Patients with Gynecological Cancers: A Population-based Cohort Study DOI
Yue Yang,

Jun-Ping Yang,

Bing-Shu Li

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

ABSTRACT Objective The survival rate of gynecological cancers (GCs) has improved significantly in recent decades. Patients with GCs did not necessarily succumb to the primary cancer. Cardiovascular health might be a critical determinant long-term survival. This study aimed investigate mortality and risk factors associated cardiovascular disease (CVD) death patients GCs. Methods A total 399,399 cases diagnosed between 2000 2020 from Surveillance, Epidemiology, End Results (SEER) database were included this study. standardized ratio (SMR) for CVD was estimated. Prognostic assessed using cause-specific hazard ratios 95% confidence intervals within competing model, considering non-cardiovascular as risk. Of GCs, 117,551 (29%) died 16,371 (4.1%) CVD. deaths, 73.2% attributed heart disease. SMR highest survivors before age 45 years, remained elevated throughout follow-up period compared general United States (US) population. In SMRs increased steadily all subtypes except vulvar Older age, black race, localized stage, unmarried/single/divorced, vaginal cancers, radiation therapy higher mortality. nomogram developed validated these variables predict Conclusions US constructed forecast individuals More attention should paid during diagnosis improve rates. HIGHLIGHTS ⇒ 29% cancer, while 4.1% CVD, deaths across GC subtypes, Higher linked older unmarried/single/divorced status, prior therapy, especially cancers. We patients, aiding personalized patient management.

Language: Английский

Citations

0
Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention DOI Creative Commons
Elena Chitoran, Roxana Elena Bohîlțea, Vlad Rotaru

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 2013 - 2013

Published: Dec. 6, 2024

Lynch syndrome, one of the most common genetic syndromes predisposing to cancer, is associated with a series malignant conditions, among which frequent colorectal but gynecologic cancers (especially endometrial) are also quite common. Despite significant progress made in understanding this condition over time, there still aspects managing that have not demonstrated clear benefits. This article aims summarize recommendations international societies and present latest developments focusing on cancer screening possible prevention strategies. Advances testing procedures discoveries related association between oncological pathology frequency affected pathogenic variant type will probably lead personalized medicine focused individual patient coming years. Although various methods for gynecological patients syndrome been used they shown survival highlights need studying implementing new diagnostic methods, under investigation recent years mentioned article.

Language: Английский

Citations

0