Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)
Published: March 22, 2025
Abstract Cancer remains a significant global health challenge, claiming numerous lives annually and posing complex hurdles in management. The disease's multifaceted nature, combined with disparities healthcare infrastructure socioeconomic factors worldwide, complicates effective treatment. With alarming mortality rates, there is an urgent need to enhance prevention early detection strategies. Early not only enables less invasive treatments but also improves the chances of successful recovery, highlighting importance proactive approaches. Lung cancer ranks highest followed by breast, prostate, colon cancers. often seen as both "genetic disease," involving gene mutations, "environmental influenced various environmental affecting expression. Metabolic alterations are hallmark cancer, disruptions cellular stability function significantly contribute its progression. Non-coding RNAs (ncRNAs) play crucial regulatory roles across cancers, diverse structures functions. They act oncogenes or tumor suppressors depending on type, intricately modulating genetic epigenetic processes. Recent studies challenge perception ncRNAs' insignificance, revealing their substantial impact mechanisms. Indeed, ncRNAs connect networks, influencing vital protein effectors that dictate responses fate. Consequently, dysregulated pivotal role disease pathogenesis, acting either oncogenic drivers through aberrant expression
Language: Английский