“Beyond the Knife”—Applying Theranostic Technologies to Enhance Outcomes in Neurosurgical Oncology DOI Creative Commons

Santosh Guru,

Fred C. Lam,

Amirhossein Akhavan-Sigari

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1253 - 1253

Published: Dec. 13, 2024

The current standard of care for brain tumor management includes maximal safe surgical resection followed by concurrent chemotherapy and radiation therapy. Recent advances in image-guided techniques have enhanced the precision resections, yet there remains a critical need innovative technologies to further improve patient outcomes. Techniques such as fluorescence neurosurgery combination with stereotactic radiosurgery improved outcomes patients tumors. In this article Brain Science’s Special Issue Advances Translational Neuro-Oncology, we review use treatment addition, summarize emerging theranostic nanoparticles delivery diagnostic therapeutic enable neurosurgeon perform more precise resections operating room, specifically target existing novel treatments cells, augment efficacy radiosurgery. These translational tools will allow neurosurgeons, neuro-oncologists, oncologists go “beyond knife” survival patients.

Language: Английский

Safety and Efficacy in the Transcortical and Transsylvian Approach in Insular High-Grade Gliomas: A Comparative Series of 58 Patients DOI Creative Commons
Alberto Morello, Francesca Rizzo, A Gatto

et al.

Current Oncology, Journal Year: 2025, Volume and Issue: 32(2), P. 98 - 98

Published: Feb. 10, 2025

Gliomas within the insular region represent one of most challenging problems in neurosurgical oncology. There are two main surgical approaches to address complex vascular network and functional areas around insula: transsylvian approach transcortical approach. In literature, there is not a clear consensus on best terms safety efficacy. The purpose this study evaluate effectiveness these analyze prognostic factors natural history gliomas. Patients with newly diagnosed high-grade gliomas who underwent surgery between January 2019 June 2024 were analyzed. series was analyzed according classification Berger-Sanai Yaşargil. Karnofsky performance score (KPS), extent resection (EOR), progression-free survival (PFS), overall (OS) considered outcome measures. A total 58 primary glioma patients enrolled study. IDH mutation found 13/58 (22.4%); specifically, 3/13 (23.1%) grade 4, 10/13 (76.9%) 3. Furthermore, 40/58 (69%) gross (GTR), 15 (26%) subtotal resection, 3 (5%) partial resection. Middle cerebral artery encasement negatively affected OS. GTR, radiotherapy, KPS, autonomous deambulation at month after positively used 11 47 cases, respectively. comparison different did display differences neurological deficits OS (p > 0.05). related greater achievement GTR = 0.031). According classification, has higher EOR postoperative KPS when lesion zone III-IV 0.029). Greater can be achieved an acceptable morbidity profile predictive improved Both corridors insula associated low profiles. intraoperative mapping more favorable for achieving EOR, particularly inferior border Sylvian fissure.

Language: Английский

Citations

0
Double Fluorescence-Guided Surgery With 5-ALA And Sodium Fluorescein In Grade 2 And Grade 3 adult-type diffuse Gliomas: Retrospective Analysis of 112 cases DOI Creative Commons
Andrea Bianconi,

Marta Bonada,

Pietro Zeppa

et al.

Brain and Spine, Journal Year: 2025, Volume and Issue: unknown, P. 104277 - 104277

Published: May 1, 2025

Language: Английский

Citations

0
Agents for Fluorescence-Guided Glioblastoma Surgery DOI Creative Commons

E. Roméo,

Andreas G. Tzakos,

Timothy Crook

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 637 - 637

Published: May 11, 2025

Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by rapid progression and a median survival of no more than 12–18 months. Fluorescence-guided surgery crucial, as it allows for tumor visualization aids in its complete removal, which essential improving rates. We conducted literature review to identify fluorescent agents that have been utilized removal GBM assess their benefits achieving maximum resection. Our analysis focuses on advantages, limitations, potential impact surgical precision patient outcomes. searched PubMed database studies published fluorescence-guided resection evaluated utility each agent terms outcomes, gross total (GTR), sensitivity specificity tumor. The revealed three successfully are 5-aminolevulinic acid (5-ALA), sodium fluorescein, indocyanine green. In addition these, variety dyes investigated studies, including peptides, lipids, nanosystems, appear be very promising. To date, numerous proposed GBM. However, (5-ALA) remains only widely adopted clinical practice, safety efficacy well-established. Further trials necessary utility, effectiveness, advantages emerging enhancing

Language: Английский

Citations

0
“Beyond the Knife”—Applying Theranostic Technologies to Enhance Outcomes in Neurosurgical Oncology DOI Creative Commons

Santosh Guru,

Fred C. Lam,

Amirhossein Akhavan-Sigari

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1253 - 1253

Published: Dec. 13, 2024

The current standard of care for brain tumor management includes maximal safe surgical resection followed by concurrent chemotherapy and radiation therapy. Recent advances in image-guided techniques have enhanced the precision resections, yet there remains a critical need innovative technologies to further improve patient outcomes. Techniques such as fluorescence neurosurgery combination with stereotactic radiosurgery improved outcomes patients tumors. In this article Brain Science’s Special Issue Advances Translational Neuro-Oncology, we review use treatment addition, summarize emerging theranostic nanoparticles delivery diagnostic therapeutic enable neurosurgeon perform more precise resections operating room, specifically target existing novel treatments cells, augment efficacy radiosurgery. These translational tools will allow neurosurgeons, neuro-oncologists, oncologists go “beyond knife” survival patients.

Language: Английский

Citations

0