Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 4, 2025

Summary Breast cancer will overtake all other cancers in terms of diagnoses 2024. counts highest among women incidence and death rates. Innovative treatment approaches are desperately needed because resistance brought on by current clinical drugs impedes therapeutic efficacy. The T cell-based immunotherapy known as chimeric antigen receptor (CAR) cell treatment, which uses the patient’s immune cells to fight cancer, has demonstrated remarkable efficacy treating hematologic malignancies; nevertheless, effects solid tumors, like breast have not lived up expectations. We discuss detail role tumor-associated antigens trials, barriers intended CAR-T therapy, potential ways increase Finally, our review aims stimulate readers’ curiosity summarizing most recent advancements therapy for cancer.

Language: Английский

Expanding the cryoprotectant toolbox in biomedicine by multifunctional antifreeze peptides

Biotechnology Advances, Journal Year: 2025, Volume and Issue: unknown, P. 108545 - 108545

Published: Feb. 1, 2025

Language: Английский

Universal CAR cell therapy: Challenges and expanding applications

Translational Oncology, Journal Year: 2024, Volume and Issue: 51, P. 102147 - 102147

Published: Oct. 15, 2024

Language: Английский