Role of circulating tumor DNA and cell-free DNA biomarkers in diagnosis and prognosis of oral cancer - a systematic review DOI Creative Commons

Samrina Mohammad,

Ihsan Ullah, Asif Ali

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 11, 2025

Abstract Background Oral squamous cell carcinoma is the most common malignant neoplasm of oral cavity, contributing significantly to cancer-related mortality worldwide. Circulating tumor DNA could be a promising biomarker for early diagnosis and prognosis cancer. Objective The aim this systematic review was consolidate existing literature on role circulating (ctDNA) cell-free (cfDNA) in Methodology protocol followed PRISMA guidelines. A search conducted across PubMed, Web Science, Google Scholar SCOPUS. Only English-language studies were included, while narrative reviews, HPV-positive OSCC, meta-analyses, abstracts, letters editor excluded. Data extracted study design, country, sample size, participant characteristics, assessment methods, type cancer measured outcomes. Risk bias evaluated using Newcastle-Ottawa Scale (NOS). Results total 3,155 records identified, out which 17 met inclusion criteria. These comprised eleven cohort studies, one case series, two descriptive three case-control studies. primarily addressed (OSCC) head neck (HNSCC). Findings revealed that elevated cfDNA levels are associated with poor prognosis, lymph node metastasis, larger size advanced disease stages. ctDNA acts as predictive tool monitoring progression, treatment response, recurrence risk, overall survival. Among 12 NOS, 8 good quality, 4 fair quality. Conclusion exhibit prognostic diagnostic potential OSCC HNSCC. Elevated correlate shows progression response.

Language: Английский

Role of circulating tumor DNA and cell-free DNA biomarkers in diagnosis and prognosis of oral cancer - a systematic review DOI Creative Commons

Samrina Mohammad,

Ihsan Ullah, Asif Ali

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 11, 2025

Abstract Background Oral squamous cell carcinoma is the most common malignant neoplasm of oral cavity, contributing significantly to cancer-related mortality worldwide. Circulating tumor DNA could be a promising biomarker for early diagnosis and prognosis cancer. Objective The aim this systematic review was consolidate existing literature on role circulating (ctDNA) cell-free (cfDNA) in Methodology protocol followed PRISMA guidelines. A search conducted across PubMed, Web Science, Google Scholar SCOPUS. Only English-language studies were included, while narrative reviews, HPV-positive OSCC, meta-analyses, abstracts, letters editor excluded. Data extracted study design, country, sample size, participant characteristics, assessment methods, type cancer measured outcomes. Risk bias evaluated using Newcastle-Ottawa Scale (NOS). Results total 3,155 records identified, out which 17 met inclusion criteria. These comprised eleven cohort studies, one case series, two descriptive three case-control studies. primarily addressed (OSCC) head neck (HNSCC). Findings revealed that elevated cfDNA levels are associated with poor prognosis, lymph node metastasis, larger size advanced disease stages. ctDNA acts as predictive tool monitoring progression, treatment response, recurrence risk, overall survival. Among 12 NOS, 8 good quality, 4 fair quality. Conclusion exhibit prognostic diagnostic potential OSCC HNSCC. Elevated correlate shows progression response.

Language: Английский

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