Dual Role of miR-150 in Colorectal Cancer Progression: A Quantitative Real-Time PCR Study DOI Creative Commons
Maryam Jasim Hasan,

Maryam Mohammed Bakheet,

Hiba Hasan Ali

et al.

Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), Journal Year: 2025, Volume and Issue: 8(1), P. 221 - 229

Published: March 18, 2025

Background: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and third most common globally. Non-coding RNAs, including miRNAs, regulate tumor microenvironment CRC play key roles in its progression. Abnormal levels miR-150 are associated with cell migration, invasion, angiogenesis. The expression fundamental biological processes influenced by profiles. Objectives: present study aimed to estimate level miR-150-3p miR-150-5p patients. Methods: involved 50 patients control participants. Liver enzyme renal functions were evaluated. miRNA was extracted from blood samples, followed complementary DNA synthesis. gene measured. Results: found a significant increase ALT ALP patients, highly differences 0.01 0.001, respectively, while AST showed no difference between groups. Urea creatinine also differences. Gene analysis revealed that similar controls (non-significant fold change 1.161), whereas reduced (fold 0.88). Conclusions: downregulated highlighting potential as diagnostic biomarker. However, changes observed levels. results may be affected factors such treatment protocols disease stages.

Language: Английский

Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research DOI
Rishabh Sharma, Jaya Yadav, Sajad Ahmad Bhat

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

Citations

1
Dual Role of miR-150 in Colorectal Cancer Progression: A Quantitative Real-Time PCR Study DOI Creative Commons
Maryam Jasim Hasan,

Maryam Mohammed Bakheet,

Hiba Hasan Ali

et al.

Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), Journal Year: 2025, Volume and Issue: 8(1), P. 221 - 229

Published: March 18, 2025

Background: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and third most common globally. Non-coding RNAs, including miRNAs, regulate tumor microenvironment CRC play key roles in its progression. Abnormal levels miR-150 are associated with cell migration, invasion, angiogenesis. The expression fundamental biological processes influenced by profiles. Objectives: present study aimed to estimate level miR-150-3p miR-150-5p patients. Methods: involved 50 patients control participants. Liver enzyme renal functions were evaluated. miRNA was extracted from blood samples, followed complementary DNA synthesis. gene measured. Results: found a significant increase ALT ALP patients, highly differences 0.01 0.001, respectively, while AST showed no difference between groups. Urea creatinine also differences. Gene analysis revealed that similar controls (non-significant fold change 1.161), whereas reduced (fold 0.88). Conclusions: downregulated highlighting potential as diagnostic biomarker. However, changes observed levels. results may be affected factors such treatment protocols disease stages.

Language: Английский

Citations

0