Comparative Analyses of the Safety Profiles of Vitamin D Receptor Agonists: A Pharmacovigilance Study Based on the EudraVigilance Database DOI Creative Commons
Zsolt Gáll, Melinda Kolcsár

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1686 - 1686

Published: Dec. 13, 2024

Background/Objectives: Vitamin D receptor (VDR) agonists are commonly used in clinical practice for their roles calcium regulation and potential benefits various diseases. However, safety profiles, particularly compounds available as food supplements, remain underexplored real-world settings. This study aimed to analyze the profiles of VDR using EudraVigilance database, focusing on adverse drug reactions (ADRs) reported between 1 January 2004 23 June 2024. Methods: Data ten were collected, de-duplicated, analyzed identify specific signals. Risk factors ADRs assessed multiple logistic regression. Results: 5,369,581 reports system, from which 17,947 (0.33%) involving 80,050 linked agonists. The most-reported drugs cholecalciferol (12,944 cases) calcitriol (1355 cases). Serious more prevalent with paricalcitol, alfacalcidol, than (p < 0.05). Hypercalcemia was a hallmark ADR all agonists, highest risk dihydrotachysterol (ROR = 5668; 95%CI 3332 9641; p 0.0001), alfacalcidol 965.7; 843.6 1106; 726.0; 634.6 830.5; 0.0001). Logistic regression highlighted dehydration, overdose, concomitant administration salts major predictors hypercalcemia. co-administration also found increase hypercalcemia risk. disproportionality analysis showed that only active (e.g., calcitriol, alfacalcidol) associated severe complications like renal urinary disorders cardiac issues due Natural precursors (cholecalciferol, ergocalciferol) often non-calcemic such gastrointestinal symptoms, infants children compared adults. Conclusions: differ significantly compounds. Active derivatives require close monitoring serious calcemia-related complications, whereas is less ADRs, primarily at-risk populations. These findings highlight need targeted further research into uses

Language: Английский

A Comprehensive Review on the Beneficial Roles of Vitamin D in Skin Health as a Bio-Functional Ingredient in Nutricosmetic, Cosmeceutical, and Cosmetic Applications DOI Creative Commons

Sofia Neonilli A. Papadopoulou,

Elena A. Anastasiou,

Theodora Adamantidi

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 796 - 796

Published: Jan. 15, 2025

Vitamin D, also called the “sunshine” vitamin, has gained great attention recently due to observed high percentage of worldwide population being deficient in this essential bioactive vitamin. Primarily, vitamin D was known for its important role bone health. Nevertheless, recent research shown importance brain, heart, muscles, immune system, and skin health, distinct bio-functionality almost every tissue human body. Therefore, deficiency been highly correlated with multiple diseases, including dermatologically associated ones. Moreover, different methodologies are applied synthesize while main sources plasma levels factors that can cause adverse modifications multiple. Further upon exhibited notable against such as psoriasis, atopic dermatitis, vitiligo, acne, rosacea. In article, a critical review most relevant significant information regarding relationship between health is thoroughly conducted, emphasis given potential uses benefits several cosmetic applications. Current status, limitations, future perspectives potent extensively discussed.

Language: Английский

Citations

2
A novel LC-MS/MS analysis of vitamin D metabolites in mice serum and hair: impact of diet and light exposure DOI Creative Commons
Muhammad K. Hakeem, Asma Al Menhali, Satheesh Elangovan

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Numerous physiological systems, such as the functioning of immune system, bone health, and regulation expression genes, depend critically on vitamin D. Considering significance D for it is critical to understand how metabolized factors that affect its levels. The objective this study was develop validate an LC-MS/MS method examine effects light exposure dietary consumption levels metabolites in a mouse model under consistent growth conditions throughout year. Serum hair samples from mice were analyzed various experimental using liquid chromatography-tandem mass spectrometry (LC-MS/MS). included D-deficient diet, D-standard changes ambient ranging complete darkness regular light-dark cycle. Mice fed standard diet exposed cycle exhibited significantly higher 25OHD3 both serum hair, indicating synergistic effect intake exposure. but kept continuous showed moderately elevated levels, demonstrating efficacy maintaining adequate despite absence light. Conversely, housed displayed below limit quantification, highlighting combined detrimental deficiency lack This provides valuable insights into complex interplay between intake, exposure, metabolism mice. Moreover, our results underscore potential implications human suggesting importance sunlight optimal Further research area has unveil additional influencing metabolism, offering strategies optimizing animal models subjects.

Language: Английский

Citations

0
Vitamin D: What role in obesity-related cancer? DOI
Pierrick Martinez, William B. Grant

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Comparative Analyses of the Safety Profiles of Vitamin D Receptor Agonists: A Pharmacovigilance Study Based on the EudraVigilance Database DOI Creative Commons
Zsolt Gáll, Melinda Kolcsár

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1686 - 1686

Published: Dec. 13, 2024

Background/Objectives: Vitamin D receptor (VDR) agonists are commonly used in clinical practice for their roles calcium regulation and potential benefits various diseases. However, safety profiles, particularly compounds available as food supplements, remain underexplored real-world settings. This study aimed to analyze the profiles of VDR using EudraVigilance database, focusing on adverse drug reactions (ADRs) reported between 1 January 2004 23 June 2024. Methods: Data ten were collected, de-duplicated, analyzed identify specific signals. Risk factors ADRs assessed multiple logistic regression. Results: 5,369,581 reports system, from which 17,947 (0.33%) involving 80,050 linked agonists. The most-reported drugs cholecalciferol (12,944 cases) calcitriol (1355 cases). Serious more prevalent with paricalcitol, alfacalcidol, than (p < 0.05). Hypercalcemia was a hallmark ADR all agonists, highest risk dihydrotachysterol (ROR = 5668; 95%CI 3332 9641; p 0.0001), alfacalcidol 965.7; 843.6 1106; 726.0; 634.6 830.5; 0.0001). Logistic regression highlighted dehydration, overdose, concomitant administration salts major predictors hypercalcemia. co-administration also found increase hypercalcemia risk. disproportionality analysis showed that only active (e.g., calcitriol, alfacalcidol) associated severe complications like renal urinary disorders cardiac issues due Natural precursors (cholecalciferol, ergocalciferol) often non-calcemic such gastrointestinal symptoms, infants children compared adults. Conclusions: differ significantly compounds. Active derivatives require close monitoring serious calcemia-related complications, whereas is less ADRs, primarily at-risk populations. These findings highlight need targeted further research into uses

Language: Английский

Citations

0