New Relevant Evidence in Cholangiocarcinoma Biology and Characterization DOI Open Access

N. M. Porro,

Elena Spínola-Lasso, Mirella Pastore

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4239 - 4239

Published: Dec. 19, 2024

Among solid tumors, cholangiocarcinoma (CCA) emerges as one of the most difficult to eradicate. The silent and asymptomatic nature this tumor, particularly in its early stages, well high heterogeneity at genomic, epigenetic, molecular levels delay diagnosis, significantly compromising efficacy current therapeutic options thus contributing a dismal prognosis. Extensive research has been conducted on pathobiology CCA, recent advances have made classification characterization new targets. Both targeted therapy immunotherapy emerged effective safe strategies for various types cancers, demonstrating potential benefits advanced CCA. Furthermore, deeper comprehension cellular components tumor microenvironment (TME) opened up possibilities innovative treatment methods. This review discusses evidence biology highlighting novel possible druggable

Language: Английский

Interdependence of macrophages and T-cells in partial spontaneous regression of intrahepatic cholangiocarcinoma in a cow: a histopathologic perspective DOI
S. Ohfuji

Comparative Clinical Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

0
Research progress of T cells in cholangiocarcinoma DOI Creative Commons
Zhiming Wang,

Yunyan Dai,

Yunpeng Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 25, 2025

Cholangiocarcinoma (CCA), a malignant tumor, is typically challenging to detect early and often results in poor prognosis. In recent years, research interest has grown the potential application of immunotherapy for CCA treatment. T cells, as crucial component immune system, play significant role surveillance therapy cholangiocarcinoma. This article provides review advancements concerning cells cholangiocarcinoma patients, including their distribution, functional status, correlation with patient prognosis within tumor microenvironment. It further discusses applications challenges strategies targeting treatment anticipates future directions. A more profound understanding cells' can guide development clinical strategies, thereby enhancing survival rates quality life. Finally, we explored risks side effects T-cell

Language: Английский

Citations

0
Research hotspots and trends in immunotherapy for cholangiocarcinoma: a bibliometric analysis (2014-2023) DOI Creative Commons

Xi-lin Qu,

Qian Wang,

Fengfeng Zhu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 26, 2024

Cholangiocarcinoma (CCA) is a malignant tumor of the gastrointestinal tract with poor prognosis. Immunotherapy plays an important role in treatment CCA. This study aimed to investigate research hotspots and trends immunotherapy for

Language: Английский

Citations

0
New Relevant Evidence in Cholangiocarcinoma Biology and Characterization DOI Open Access

N. M. Porro,

Elena Spínola-Lasso, Mirella Pastore

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4239 - 4239

Published: Dec. 19, 2024

Among solid tumors, cholangiocarcinoma (CCA) emerges as one of the most difficult to eradicate. The silent and asymptomatic nature this tumor, particularly in its early stages, well high heterogeneity at genomic, epigenetic, molecular levels delay diagnosis, significantly compromising efficacy current therapeutic options thus contributing a dismal prognosis. Extensive research has been conducted on pathobiology CCA, recent advances have made classification characterization new targets. Both targeted therapy immunotherapy emerged effective safe strategies for various types cancers, demonstrating potential benefits advanced CCA. Furthermore, deeper comprehension cellular components tumor microenvironment (TME) opened up possibilities innovative treatment methods. This review discusses evidence biology highlighting novel possible druggable

Language: Английский

Citations

0