Exploring the metabolic alterations in cervical cancer induced by HPV oncoproteins: From mechanisms to therapeutic targets DOI Creative Commons

Mrudula Gore,

Shama Prasada Kabekkodu, Sanjiban Chakrabarty

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189292 - 189292

Published: March 1, 2025

The role of human Papillomavirus (HPV) in metabolic reprogramming is implicated the development and progression cervical cancer. During carcinogenesis, cancer cells modify various pathways to generate energy sustain their growth development. Cervical cancer, one most prevalent malignancies affecting women globally, involves alterations such as increased glycolysis, elevated lactate production, lipid accumulation. oncoproteins, primarily E6 E7, which are encoded by high-risk HPVs, facilitate accumulation several markers, promoting not only but also metastasis, immune evasion, therapy resistance. HPV oncoproteins interact with cellular MYC (c-MYC), retinoblastoma protein (pRB), p53, hypoxia-inducible factor 1α (HIF-1α), leading induction favour Warburg effect. Metabolic enables persist for an extended period accelerates This review summarizes contributions Additionally, this provides insights into how opens avenues novel therapeutic strategies, including discovery new repurposed drugs that could be applied treat

Language: Английский

Relationship Between Human Papilloma Virus and Upper Gastrointestinal Cancers DOI Creative Commons
Ömer Vefik Özozan, Hikmet Pehlevan Özel, Veli Vural

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 367 - 367

Published: March 4, 2025

The human papillomavirus (HPV) is an oncogenic DNA virus that the most commonly transmitted sexually virus. There substantial evidence HPV associated with different types of cancer. While majority studies have concentrated on urogenital system cancers and head neck cancers, relationship between gastrointestinal particularly esophageal has also been subject investigation. Given a disease can be prevented through vaccination treated antiviral agents, identifying pathogen may inform treatment these cancers. This comprehensive review examines upper tract, highlighting mechanisms its reported prevalence. A deeper understanding HPV’s association cancer relevant to further development therapies.

Language: Английский

Citations

1
Exploring the metabolic alterations in cervical cancer induced by HPV oncoproteins: From mechanisms to therapeutic targets DOI Creative Commons

Mrudula Gore,

Shama Prasada Kabekkodu, Sanjiban Chakrabarty

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189292 - 189292

Published: March 1, 2025

The role of human Papillomavirus (HPV) in metabolic reprogramming is implicated the development and progression cervical cancer. During carcinogenesis, cancer cells modify various pathways to generate energy sustain their growth development. Cervical cancer, one most prevalent malignancies affecting women globally, involves alterations such as increased glycolysis, elevated lactate production, lipid accumulation. oncoproteins, primarily E6 E7, which are encoded by high-risk HPVs, facilitate accumulation several markers, promoting not only but also metastasis, immune evasion, therapy resistance. HPV oncoproteins interact with cellular MYC (c-MYC), retinoblastoma protein (pRB), p53, hypoxia-inducible factor 1α (HIF-1α), leading induction favour Warburg effect. Metabolic enables persist for an extended period accelerates This review summarizes contributions Additionally, this provides insights into how opens avenues novel therapeutic strategies, including discovery new repurposed drugs that could be applied treat

Language: Английский

Citations

0