Enhanced Lymph Node Detection in Colon Cancer Using Indocyanine Green Fluorescence: A Systematic Review of Studies from 2020 Onwards

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(2), P. 54 - 54

Published: Jan. 29, 2025

Background: Colon cancer is known as one of the most prevalent malignancies in world. This well-known pathology requires accurate lymph node dissection to achieve effective staging and improved treatment outcomes. Indocyanine green fluorescence imaging has been used a new technique for enhancing visualization during surgical intervention. The high rates local recurrence colon patients require innovative methods improve lymphatic mapping dissection. review evaluates clinical utility efficacy ICG accuracy surgery. Materials methods: A systematic search was conducted October 2024 (last day consulting database 16 November) across Web Science, Scopus, PubMed identify studies published from 2020 onwards focusing on use indocyanine surgeries. terms were “indocyanine green”, “ICG”, “fluorescent imaging”, “near-infrared “colon cancer”, “colorectal carcinoma”,” neoplasms”, “surgery”, “surgical procedure”, resection”, precision”. followed PRISMA guidelines. records underwent two-phase independent screening process by authors, first based title abstract, full record evaluation. Articles excluded following certain exclusion criteria: non-human studies; restricted access publications; other publication type than article (review, meta-analysis, questionnaire-based study, case report, etc.), diseases or that focused metastasis cancer; foreign language (non-English); no data interest current review; rectal grouped cancer. Data extraction involved both quantitative qualitative data, such detection rates, sensitivity, specificity, Risk bias assessed using ROBINS-I, J Joanna Briggs Institute (JBI) Critical Appraisal Checklist, Newcastle–Ottawa Scale, depending study type. not preregistered PROSPERO. However, ensure methodological rigor transparency, it retrospectively registered Open Science Framework (OSF). Results: From 3300 initially identified, 9 included this review. Detection varied 55% 100%, with highest rate reported robot-assisted showed an flow fluorescence. Discussion: demonstrated substantial benefits, improving potentially reducing guiding lymphadenectomy. variability observed largely attributed differences administration, stage, approaches. Conclusions: ICG-guided surgery represents promising advancement, accuracy. Large-scale randomized trials are essential establish standardized protocols validate

Language: Английский

The Medical Basis for the Photoluminescence of Indocyanine Green

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 888 - 888

Published: Feb. 14, 2025

Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye with unique photoluminescent properties, is helpful tool in many medical applications. ICG produces fluorescence when excited by NIR light, enabling accurate tissue visualization and real-time imaging. This study investigates the fundamental processes behind ICG's photoluminescence as well its present possible applications treatments diagnostics. Fluorescence-guided surgery (FGS) has been transformed capacity to visualize tumors, highlight blood flow, facilitate lymphatic mapping, all of which have improved surgical accuracy patient outcomes. Furthermore, being studied for new therapeutic approaches, like photothermal therapy, light can activate target destroy cancer cells. We go over benefits drawbacks qualities contexts, current studies that focus on improving effectiveness, security, adaptability. More precise disease detection, monitoring, tailored therapy options across variety specialties are made ongoing advancement ICG-based imaging methods therapies. In main part our work, we strive take into account latest reports; therefore, used clinical articles going back 2020. However, sake theoretical part, oldest article us from 1995.

Language: Английский

Optimal Indocyanine Green Dosage for Repetitive Angiography for Laparoscopic Colorectal Surgery

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1966 - 1966

Published: Nov. 29, 2024

Background and Objectives: This study aimed to determine the minimal effective dose of indocyanine green (ICG) required for accurately assessing colonic perfusion during laparoscopic colorectal surgery using a laser-assisted near-infrared (NIR) camera system. Materials Methods: In 15 patients with cancer undergoing right hemicolectomy, left branch middle colic artery was preserved, ICG angiography performed in transverse colon. To optimal dose, experimental doses 0.01, 0.02, 0.03, 0.04, 0.05 mg per patient’s body weight (kg) were administered intravenously each group. Additionally, conventional 0.2 mg/kg same more than 30 min after initial dose. For quantitative analysis, fluorescent expression region extracted, fluorescence intensity analyzed automatic image processing. Analysis accessibility, T1/2MAX, time ratio, slope, artificial intelligence (AI)-based pattern washout measured 150 detailed regions interest image. Results: Group 1 (0.01 mg/kg) showed significantly lower accessibility rates analysis (48.0%) compared Groups 2–5 (84.7–100%). The mean slope value 3.7, which fell below acceptable threshold (>4) that other groups (p < 0.001). An AI-based 14.2% 1, (66.4–100%). Washout faster (39.0 ± 15.8 s vs. 117.5 4.9 s, respectively, p Conclusions: supports use doses, ranging from 0.02 mg/kg, optimize repetitive NIR camera.

Language: Английский