Leukoencephalopathy following stereotactic radiosurgery for breast cancer brain metastases: a single-center analysis of 1,077 lesions DOI Creative Commons
Salem M. Tos, Bardia Hajikarimloo, Georgios Mantziaris

et al.

Acta Neurochirurgica, Journal Year: 2025, Volume and Issue: 167(1)

Published: March 14, 2025

Abstract Background Leukoencephalopathy is the most prevalent and delayed adverse radiation effect (ARE) after intracranial radiotherapy (RT). Patients with leukoencephalopathy experience some levels of cognitive neurological dysfunction. This investigation assessed frequency clinical outcomes following stereotactic radiosurgery (SRS) alone or SRS whole-brain therapy (WBRT) in breast cancer brain metastasis. Methods We retrospectively evaluated data metastases from individuals who underwent between 2007 2022. MRI sequences were examined to assess white matter changes tumor control. Results Among 125 patients 1,077 metastases, 58 (46.4%) received WBRT prior SRS. By year 3, 23.4% + developed high-grade (grades 2–3) compared 5.7% SRS-only group ( p < 0.001). In univariate analyses, significant predictors included (HR: 18.4, = 0.005), cumulative integral dose > 3 J 4.17, 0.029), total number lesions 1.22, multivariate 11.1, 0.022) 1.14, 0.037) remained predictors. Conclusion Our findings demonstrated that plus associated higher rates than alone. underscores importance carefully weighing benefits risks different ionizing approaches management metastasis cancer.

Language: Английский

Leukoencephalopathy following stereotactic radiosurgery for breast cancer brain metastases: a single-center analysis of 1,077 lesions DOI Creative Commons
Salem M. Tos, Bardia Hajikarimloo, Georgios Mantziaris

et al.

Acta Neurochirurgica, Journal Year: 2025, Volume and Issue: 167(1)

Published: March 14, 2025

Abstract Background Leukoencephalopathy is the most prevalent and delayed adverse radiation effect (ARE) after intracranial radiotherapy (RT). Patients with leukoencephalopathy experience some levels of cognitive neurological dysfunction. This investigation assessed frequency clinical outcomes following stereotactic radiosurgery (SRS) alone or SRS whole-brain therapy (WBRT) in breast cancer brain metastasis. Methods We retrospectively evaluated data metastases from individuals who underwent between 2007 2022. MRI sequences were examined to assess white matter changes tumor control. Results Among 125 patients 1,077 metastases, 58 (46.4%) received WBRT prior SRS. By year 3, 23.4% + developed high-grade (grades 2–3) compared 5.7% SRS-only group ( p < 0.001). In univariate analyses, significant predictors included (HR: 18.4, = 0.005), cumulative integral dose > 3 J 4.17, 0.029), total number lesions 1.22, multivariate 11.1, 0.022) 1.14, 0.037) remained predictors. Conclusion Our findings demonstrated that plus associated higher rates than alone. underscores importance carefully weighing benefits risks different ionizing approaches management metastasis cancer.

Language: Английский

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