A Comprehensive Review of Niobium Nanoparticles: Synthesis, Characterization, Applications in Health Sciences, and Future Challenges

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(2), P. 106 - 106

Published: Jan. 12, 2025

Niobium nanoparticles (NbNPs) have gained attention as promising materials in biomedical applications due to their exceptional biocompatibility, corrosion resistance, and versatility. These offer potential drug delivery, imaging, tissue engineering, where nanoscale properties allow precise interactions with biological systems. Among niobium-based nanomaterials, niobium pentoxide (Nb2O5) is the most extensively studied its chemical stability, bioactivity, optical properties. Nb2O5 shown significant catalysis, biosensing, photodynamic therapy, stability reactivity make them ideal for functionalization advanced applications. Despite these advantages, challenges remain regarding biodegradability long-term retention of NbNPs Their accumulation tissues can lead risks such chronic inflammation or toxicity, emphasizing importance designing controlled clearance biodegradability. Surface modifications, coatings biocompatible polymers, demonstrated ability mitigate while enhancing therapeutic efficacy. This review provides a comprehensive overview NbNPs, focus on Nb2O5, highlighting unique properties, current applications, limitations. By addressing remaining challenges, this work aims guide development safer more effective nanomaterials future medical innovations.

Language: Английский

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Revolutionizing Oncology: Iron Oxide Nanoparticles in Cancer Diagnosis and Treatment

International Journal of Scientific Research in Science and Technology, Journal Year: 2025, Volume and Issue: 12(1), P. 161 - 173

Published: Jan. 26, 2025

Iron oxide nanoparticles (IONPs) have emerged as a transformative tool in oncology, offering unprecedented opportunities for early cancer diagnosis and effective treatment. These exhibit unique physicochemical properties, including superparamagnetism, biocompatibility, large surface area-to-volume ratio. properties make them particularly suitable applications such high-resolution imaging, targeted drug delivery, hyperthermia therapy. Additionally, their ability to be functionalized with various biomolecules enables precision targeting of cancerous tissues, further enhancing efficacy. This article delves into the cutting-edge advancements utilization IONPs, examines multifunctional roles addresses challenges clinical translation, outlines future directions research application this dynamic field.

Language: Английский

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Iron Oxide Nanoparticles as Enhancers for Radiotherapy of Tumors

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

This research aimed to evaluate the potency of preparation based on heparinized iron oxide nanoparticles (hIONPs) in combination with radiation therapy, including magnetic delivery via applied field (AMF), sarcoma and cervical cancer models. For vitro studies, cells rhabdomyosarcoma (RD), fibrosarcoma (HT1080), (HeLa S3) were treated hIONPs analyzed for survival rate hIONP uptake. Then, cell morphology, cycle, increase reactive oxygen species, mitochondria depolarization, ability form colonies assessed combined treatment (hIONPs + 3Gy). vivo research, administered once hybrids CBAxC57Bl/6j mice, grafted (S37) (CC5) strains. The ultimate modes were: (1) i.v. (14 μg/kg) 5 Gy; (2) AMF (3) i.t. (2,8 Gy. overall rates, life expectancy, inhibition tumor growth (tumor inhibition), degree (T/C) determined, pathomorphological changes experimental groups. 3Gy) promotes multiple death high-severity peroxide effects compared other more sensitive than cells. vivo, an enhancing effect was revealed by radiotherapy magnetic-delivered hIONPs. S37 tumor, regimen characterized as having a high antitumor effect, ≪++++ ≫, 20% cure mice. CC5 accompanied growth, expectancy animals, significant ≪+++/++ ≫. From data obtained, it can be concluded that radiosensitizing potential may taken basis protocols.

Language: Английский

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Erbium oxide nanoparticles induce potent cell death, genomic instability and ROS-mitochondrial dysfunction-mediated apoptosis in U937 lymphoma cells

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Erbium oxide nanoparticles (Er 2 O 3 -NPs) have attracted significant attention for their unique physicochemical properties, including high surface area, biocompatibility, and stability. However, the impact of Er -NPs on lymphoma cells (LCs) has not been explored, making this an innovative avenue exploration. Therefore, current study aimed to explore influence cell viability, genomic mitochondrial DNA integrity, reactive oxygen species (ROS) generation apoptosis induction in human U937 LCs. were characterized using X-ray diffraction (XRD) transmission electron microscopy (TEM). The effect viability integrity was estimated after 48 h WST-1 cytotoxicity alkaline Comet assays, respectively. level membrane potential also analyzed. Flow Cytometry used assess quantitative RT-PCR conducted measure apoptotic ( p53 ), anti-apoptotic Bcl2 ND3 ) gene expression. Our results demonstrated purity well distribution revealed that induce strong cells, as evidenced by a concentration-dependent reduction with IC50 value 3.20 µg/ml. Exposure LCs concentration (3.20 µg/ml) promoted excessive ROS generation, leading dramatic damage potential, marked dysregulation This cascade events triggered both necrosis -NPs-treated In conclusion, these findings highlight vitro cytotoxic against highly aggressive LCs, mediated production, which leads severe damage, profound alterations apoptotic, Future research is needed further investigate use treating optimize therapeutic efficacy.

Language: Английский

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Stabilization and enhanced anticancer activity of zinc oxide nanoparticles functionalized with chitosan and terephthalic acid

Journal of Sol-Gel Science and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

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Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer

Hereditas, Journal Year: 2025, Volume and Issue: 162(1)

Published: April 17, 2025

Abstract Lung cancer remains one of the leading causes cancer-related death worldwide, with a significant number patients succumbing to disease each year. Olea europaea, commonly known as olive tree, offers range health benefits due its rich content antioxidants. In present study, we have reported green synthesis bimetallic nanocomposite zinc and copper using leaf extract europae (Zn/Cu NCs@ europaea ). The nanoparticles were characterized common chemical techniques. antioxidant activity Zn/Cu was evaluated DPPH assay. cytotoxicity anti-lung investigated MTT results XRD analysis FE-SEM imaging showed crystalline structure for semi-spherical morphology an average size 49.37 nm. scavenged free radical IC 50 363.42 ± 5.02 µg/mL. Furthermore, exhibited acceptable by preventing growth in cell lines SK-MES-1, A-549, LK-2 154.00 1.83, 228.83 10.59, 250.55 8.04 µg/mL respectively. NPs inactive against normal HUVEC even at high concentrations. study indicate that , which is synthesized sufficient nano size, can be considered potent agent.

Language: Английский

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