Exosomal Lipids in Cancer Progression and Metastasis

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(6)

Published: March 1, 2025

Metastasis is the primary cause of cancer mortality. It responsible for 90% all cancer-related deaths. Intercellular communication a crucial feature underlying metastasis and progression. Cancerous tumors secrete membrane-derived small extracellular vesicles (30-150 nm) into their milieu. These tiny organelles, known as exosomes, facilitate intercellular by transferring bioactive molecules. exosomes harbor different cargos, such proteins, nucleic acids, lipids, that mediate multifaceted functions in various oncogenic processes. Of note, amount lipids multifold higher than other cargos. Most studies have investigated role exosomes' protein acid content processes, while lipid cargo pathophysiology remains largely obscure. We conducted an extensive literature review on progression, specifically addressing topic exosomal involvement This aims to shed light contents metastasis. In this context, signaling pathways, immunomodulation, energy production cell survival provides insights overcoming progression

Language: Английский

Epigenetic Inactivation of RIPK3-Dependent Necroptosis Augments Cisplatin Chemoresistance in Human Osteosarcoma

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3863 - 3863

Published: April 18, 2025

Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents. Unfortunately, drug resistance limits efficacy of chemotherapeutic treatment compromises therapeutic outcomes a substantial proportion cases. Aberrant CpG island methylation-associated transcriptional silencing contributes to chemoresistance pediatric solid tumors. Here, using whole-genome DNA methylation screening on 16 human OS specimens, we identify receptor interacting protein kinase-3 (RIPK3), molecular regulator necroptosis programmed cell death pathway, as gene target aberrant demonstrate its role chemoresistance. We validated these findings via enforced expression DsiRNA silencing, evaluated RIPK3 cisplatin chemosensitivity activation through MLKL phosphorylation. found that results samples lines. Enforced significantly enhanced cytotoxicity cells knockdown reversed cisplatin-sensitive phenotype. In with expression, increased phosphorylation both target, MLKL, indicative induction necroptosis. an important mediator potential pharmacologic improve chemotherapy drug-resistant

Language: Английский

Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(17)

Published: April 29, 2025

Gastric cancer (GC), the fifth most common malignancy worldwide, poses a substantial challenge in clinical oncology, particularly its advanced stages. Despite advancements immunotherapy, patient prognosis remains poor, underscoring need for reliable prognostic tools to refine treatment strategies. A study by Yao et al explores role of triglyceride-glucose (TyG) index as marker GC patients receiving immunotherapy combined with chemotherapy. The results demonstrate that TyG correlates improved survival outcomes, including better progression-free and overall survival. This editorial critically evaluates significance these findings, discusses their implications future research, highlights innovative directions could drive further breakthroughs application therapy. also potential advancing precision oncology advocates global validation mechanistic investigations solidify utility. Future research should focus on validating across various malignancies, exploring influence through metabolic interventions, developing multi-biomarker models integrate immune genomic profiles.

Language: Английский