CALR regulates the proliferation and drug sensitivity of multiple myeloma cells through the BCL2 signaling pathway
Abstract
Background :
Calreticulin
(CALR)
has
been
implicated
in
the
genesis
and
progression
of
numerous
tumors.
Nevertheless,
its
impact
on
multiple
myeloma
(MM)
remains
ambiguous.
This
study
aimed
to
explore
effect
CALR
proliferation
drug
sensitivity
MM
cells
delve
into
underlying
mechanism.
Methods:
First,
expression
was
measured.
Subsequently,
knockdown
validated
both
vitro
vivo.
Finally,
RNA
sequencing
utilized
molecular
mechanisms
associated
with
knockdown.
Results:
We
determined
that
is
upregulated
cells.
Both
vivo
functional
assays
demonstrated
attenuated
proliferative
capacity
cells,
heightened
their
bortezomib
(BTZ),
facilitated
cell
apoptosis.
RNA-sequencing
results
indicated
activates
apoptosis
pathway,
mechanism
potentially
involving
regulation
BCL2
signaling
pathway.
Conclusion:
This
indicates
MM.
Targeting
might
be
a
potential
strategy
further
enhance
treatment
efficacy
for
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: April 29, 2025
Language: Английский