Ubiquitination in lipid metabolism reprogramming: implications for pediatric solid tumors DOI Creative Commons
Weixin Zhang,

Yile Xu,

Yapeng Fang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Pediatric solid tumors represent a significant subset of childhood cancers, accounting for approximately 60% new diagnoses. Despite advancements in therapeutic strategies, survival rates remain markedly disparate between high-income and resource-limited settings, underscoring the urgent need novel effective treatments. Lipid metabolic reprogramming is fundamental hallmark cancer, driving tumor progression, resistance, immune evasion through enhanced fatty acid uptake, increased de novo lipid synthesis, activated β-oxidation (FAO). Ubiquitination, dynamic post-translational modification mediated by ubiquitin-proteasome system (UPS), plays crucial role regulating metabolism modulating stability activity key enzymes transporters involved cholesterol pathways. This review comprehensively examines complex interplay ubiquitination pediatric tumors. It delineates mechanisms which influences biosynthesis, efflux, synthesis oxidation, thereby facilitating growth survival. Furthermore, identifies potential UPS-mediated targets explores feasibility integrating ubiquitination-based strategies with existing By targeting UPS to disrupt pathways, avenues may emerge enhance treatment efficacy overcome resistance oncology. current knowledge aims provide foundation development innovative, precision medicine approaches improve clinical outcomes children afflicted

Language: Английский

Ubiquitination in lipid metabolism reprogramming: implications for pediatric solid tumors DOI Creative Commons
Weixin Zhang,

Yile Xu,

Yapeng Fang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Pediatric solid tumors represent a significant subset of childhood cancers, accounting for approximately 60% new diagnoses. Despite advancements in therapeutic strategies, survival rates remain markedly disparate between high-income and resource-limited settings, underscoring the urgent need novel effective treatments. Lipid metabolic reprogramming is fundamental hallmark cancer, driving tumor progression, resistance, immune evasion through enhanced fatty acid uptake, increased de novo lipid synthesis, activated β-oxidation (FAO). Ubiquitination, dynamic post-translational modification mediated by ubiquitin-proteasome system (UPS), plays crucial role regulating metabolism modulating stability activity key enzymes transporters involved cholesterol pathways. This review comprehensively examines complex interplay ubiquitination pediatric tumors. It delineates mechanisms which influences biosynthesis, efflux, synthesis oxidation, thereby facilitating growth survival. Furthermore, identifies potential UPS-mediated targets explores feasibility integrating ubiquitination-based strategies with existing By targeting UPS to disrupt pathways, avenues may emerge enhance treatment efficacy overcome resistance oncology. current knowledge aims provide foundation development innovative, precision medicine approaches improve clinical outcomes children afflicted

Language: Английский

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