Biomarkers of Survival in Patients with Colorectal Liver Metastases Treated with Percutaneous Microwave Ablation DOI Open Access
J Franke, Grzegorz Rosiak, Krzysztof Milczarek

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1112 - 1112

Published: March 26, 2025

Background/Objectives: To evaluate the prognostic value of easily obtainable biomarkers for patients undergoing percutaneous microwave ablation (MWA) colorectal liver metastases (CLMs). Prior studies showed that simple biomarkers, such as lymphocyte-to-monocyte ratio (LMR), albumin-to-globulin (AGR), platelet-to-lymphocyte (PLR), and neutrophil-to-lymphocyte (NLR), well cancer-specific markers, like carcinoembryonic antigen (CEA), might have a role in various malignancies; however, none these were assessed MWA CLMs. Methods: Based on laboratory results, which determined prior to ablation, several including LMR, AGR, PLR, NLR, calculated. The log-rank test's optimal cutoff points continuous variables determined. Subsequently, univariable multivariable Cox regression models utilized determine association between features overall survival (OS). Results: This study included 57 CLM with mean age 63 ± 12.5 years at time follow up 30.9 months. model demonstrated high level CEA (cutoff: 29.1 ng/mL; HR: 3.70) LMR 5.32; 4.05) related worse OS, whereas NLR 2.05; 0.31) primary left-sided colon cancer (HR: 0.36) positive factors. confirmed findings, exception was no longer significantly associated OS. Conclusions: demonstrates feasibility prediction thus patient stratification based clinicopathological MWA.

Language: Английский

Biomarkers of Survival in Patients with Colorectal Liver Metastases Treated with Percutaneous Microwave Ablation DOI Open Access
J Franke, Grzegorz Rosiak, Krzysztof Milczarek

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1112 - 1112

Published: March 26, 2025

Background/Objectives: To evaluate the prognostic value of easily obtainable biomarkers for patients undergoing percutaneous microwave ablation (MWA) colorectal liver metastases (CLMs). Prior studies showed that simple biomarkers, such as lymphocyte-to-monocyte ratio (LMR), albumin-to-globulin (AGR), platelet-to-lymphocyte (PLR), and neutrophil-to-lymphocyte (NLR), well cancer-specific markers, like carcinoembryonic antigen (CEA), might have a role in various malignancies; however, none these were assessed MWA CLMs. Methods: Based on laboratory results, which determined prior to ablation, several including LMR, AGR, PLR, NLR, calculated. The log-rank test's optimal cutoff points continuous variables determined. Subsequently, univariable multivariable Cox regression models utilized determine association between features overall survival (OS). Results: This study included 57 CLM with mean age 63 ± 12.5 years at time follow up 30.9 months. model demonstrated high level CEA (cutoff: 29.1 ng/mL; HR: 3.70) LMR 5.32; 4.05) related worse OS, whereas NLR 2.05; 0.31) primary left-sided colon cancer (HR: 0.36) positive factors. confirmed findings, exception was no longer significantly associated OS. Conclusions: demonstrates feasibility prediction thus patient stratification based clinicopathological MWA.

Language: Английский

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