Cytokine-based immunotherapy for gastric cancer: targeting inflammation for tumor control DOI Creative Commons

Mathan Muthu Chinakannu Marimuthu,

Bhavani Sowndharya Balamurugan,

Sundaram Vickram

et al.

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: 6

Published: April 26, 2025

Emerging cancer immunotherapy methods, notably cytokine-based ones that modify immune systems’ inflammatory reactions to tumor cells, may help slow gastric progression. Cytokines, tiny signaling proteins communicate between or hinder growth. Pro-inflammatory cytokines encourage development, whereas antitumor the host reject cells. This study considers cytokine-targeted methods for pro-inflammatory and responses. Researchers want renew cells like cytotoxic T lymphocytes (CTLs) natural killer (NK) by delivering interleukin-2 (IL-2), interferons (IFNs), necrosis factor-alpha (TNF-α) activate pathways combat tumors. Since have significant pleiotropic effects, their therapeutic use is difficult cause excessive systemic inflammation immunological suppression. review covers current advancements in synthetic cytokines, cytokine-conjugates, local administration of these aimed enhance index: increase potential kill while minimizing off-target damage. The examines relationship microenvironment (TME), revealing role immunosuppressive IL-10 transforming growth factor-beta (TGF-β) promoting an immune-evasive phenotype. These results suggest inhibitory pathway targeting, therapy overcome resistance mechanisms. Cytokine-based immunotherapies combined with checkpoint inhibitors are predicted change rebuild tumor-immune dynamics, restoring immunity. Comprehensive data from clinical studies will assist establishing position treatments cancer.

Language: Английский

Cytokine-based immunotherapy for gastric cancer: targeting inflammation for tumor control DOI Creative Commons

Mathan Muthu Chinakannu Marimuthu,

Bhavani Sowndharya Balamurugan,

Sundaram Vickram

et al.

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: 6

Published: April 26, 2025

Emerging cancer immunotherapy methods, notably cytokine-based ones that modify immune systems’ inflammatory reactions to tumor cells, may help slow gastric progression. Cytokines, tiny signaling proteins communicate between or hinder growth. Pro-inflammatory cytokines encourage development, whereas antitumor the host reject cells. This study considers cytokine-targeted methods for pro-inflammatory and responses. Researchers want renew cells like cytotoxic T lymphocytes (CTLs) natural killer (NK) by delivering interleukin-2 (IL-2), interferons (IFNs), necrosis factor-alpha (TNF-α) activate pathways combat tumors. Since have significant pleiotropic effects, their therapeutic use is difficult cause excessive systemic inflammation immunological suppression. review covers current advancements in synthetic cytokines, cytokine-conjugates, local administration of these aimed enhance index: increase potential kill while minimizing off-target damage. The examines relationship microenvironment (TME), revealing role immunosuppressive IL-10 transforming growth factor-beta (TGF-β) promoting an immune-evasive phenotype. These results suggest inhibitory pathway targeting, therapy overcome resistance mechanisms. Cytokine-based immunotherapies combined with checkpoint inhibitors are predicted change rebuild tumor-immune dynamics, restoring immunity. Comprehensive data from clinical studies will assist establishing position treatments cancer.

Language: Английский

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