Association Between Pentraxins and Obesity in Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus Patients DOI Open Access

Roxana-Viorela Ahrițculesei,

Lidia Boldeanu,

Daniel Cosmin Caragea

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3661 - 3661

Published: April 12, 2025

Systemic inflammation has an important role in the prognosis and progression of many chronic diseases, including diabetes (T2DM). This retrospective study aimed to evaluate inflammatory status by determining serum biomarkers (PTX3, hs-CRP, TNF-α, IL-6) new indices, like mean corpuscular volume (MCV) lymphocyte ratio (MCVL) cumulative index (IIC), a cohort patients with prediabetes (PreDM) newly diagnosed T2DM. We also wanted assess association clinical parameters different obesity-related identify possible correlations diagnostic accuracy using ROC curve analysis. In this study, we included 60 T2DM 30 PreDM. The ELISA method was applied. Elevated PTX3, IL-6 levels were found compared preDM patients. An independent relationship between indices MCVL exhibited inverse trend proportional rising HbA1c group. Spearman’s analysis revealed group that PTX3 values correlated much better IIC (rho = 0.445, p-value 0.014) 0.338, 0.048). Hs-CRP expressed moderate-to-weak both groups. Additionally, showed (AUC 0.720; p 0.003; cut-off value 1888.00 pg/mL, 67.60% sensitivity 73.30% specificity) 0.677; 0.047; 39.60, 63.30% 66.70% have good, accurate diagnosis 0.866; < 0.0001; 40.30 100.00% 60.00% specificity). 61.70% specificity, AUC 0.572, 0.027 2.35. can serve as predictor factors patients, supporting their potential for management future research.

Language: Английский

Association Between Pentraxins and Obesity in Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus Patients DOI Open Access

Roxana-Viorela Ahrițculesei,

Lidia Boldeanu,

Daniel Cosmin Caragea

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3661 - 3661

Published: April 12, 2025

Systemic inflammation has an important role in the prognosis and progression of many chronic diseases, including diabetes (T2DM). This retrospective study aimed to evaluate inflammatory status by determining serum biomarkers (PTX3, hs-CRP, TNF-α, IL-6) new indices, like mean corpuscular volume (MCV) lymphocyte ratio (MCVL) cumulative index (IIC), a cohort patients with prediabetes (PreDM) newly diagnosed T2DM. We also wanted assess association clinical parameters different obesity-related identify possible correlations diagnostic accuracy using ROC curve analysis. In this study, we included 60 T2DM 30 PreDM. The ELISA method was applied. Elevated PTX3, IL-6 levels were found compared preDM patients. An independent relationship between indices MCVL exhibited inverse trend proportional rising HbA1c group. Spearman’s analysis revealed group that PTX3 values correlated much better IIC (rho = 0.445, p-value 0.014) 0.338, 0.048). Hs-CRP expressed moderate-to-weak both groups. Additionally, showed (AUC 0.720; p 0.003; cut-off value 1888.00 pg/mL, 67.60% sensitivity 73.30% specificity) 0.677; 0.047; 39.60, 63.30% 66.70% have good, accurate diagnosis 0.866; < 0.0001; 40.30 100.00% 60.00% specificity). 61.70% specificity, AUC 0.572, 0.027 2.35. can serve as predictor factors patients, supporting their potential for management future research.

Language: Английский

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