Giant,
Journal Year:
2024,
Volume and Issue:
19, P. 100314 - 100314
Published: June 28, 2024
In
this
work,
for
the
first
time,
films
were
obtained
based
on
biodegradable
polyhydroxyalkanoates
(PHAs)
-
a
copolymer
of
3-hydroxybutyrate-co-3-hydroxyvalerate
P(3HB-co-3HV)
and
3-hydroxybutyrate-co-4-hydroxybutyrate
P(3HB-co-4HB),
containing
drugs
different
chemical
structure
action
antibiotics
(ceftazidime,
doripenem),
antiseptic
(chlorhexidine)
tissue
regeneration
stimulator
(Actovegin)
drug
delivery
cell
culture.
Using
SEM,
AFM
measuring
contact
angles
water
wetting,
it
is
shown
how
PHAs
composition
loading
P(3HB-co-4HB)
with
affect
porosity,
roughness
indicators
adhesive
properties
surface.
The
constructed
are
depot
form
drug,
release
which
in
vitro
realized
long
without
burst
releases,
corresponds
to
Korsmeyer-Peppas
Higuchi
models
diffusion
character.
Films
loaded
have
pronounced
antibacterial
activity
suppress
development
pathogens
S.
aureus
E.
coli,
negative
effect
adhesion
proliferation
epidermal
cells.
cultures
human
keratinocytes
HaCaT
was
that
presence
actovegin,
as
well
ceftazidime
films,
exhibits
stimulating
effect,
increasing
their
number.
results
demonstrate
suitability
depot-films
cellular
technologies
promising
reconstruction
tissues
complicated
by
infection.
Results in Engineering,
Journal Year:
2023,
Volume and Issue:
20, P. 101511 - 101511
Published: Oct. 18, 2023
Eco-friendly
bio-active
materials
designed
from
available
natural
resources
have
been
signified
a
big
challenge
in
the
past
few
decades.
Nevertheless,
deficiency
of
most
essential
knowledge
regarding
effective
processing
starting
which
has
used
to
fabricate
targeted
bio-polymeric
composites
framework
is
considered
foremost
encounter.
However,
cellulosic
fibers
(generally
extracted
different
parts
plants
like
bast/bark,
leaf,
steam)
received
more
attention
researchers,
due
their
outstanding
physiochemical,
thermomechanical,
morphological
properties
and
eco-friendly
nature/sustainability.
Basically,
features
hinge
on
proper
preparation
modification
process.
Conversely,
main
problem
fiber
its
hydrophilic
nature
while
polymeric
matrix
are
hydrophobic
thus
it
urgent
reduce
by
conducting
various
significant
chemical
techniques
so
as
improve
overall
quality
reinforcement
sustainable
biocomposite.
Therefore,
will
be
proposed
with
detailed
overview
focusing
notable
process
modifications
characterization
methods
this
review.
We
also
summarize
important
findings
earlier
literature
effects
treatments
being
emphasized.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 12, 2023
Petro-plastic
wastes
cause
serious
environmental
contamination
that
require
effective
solutions.
Developing
alternatives
to
petro-plastics
and
exploring
feasible
degrading
methods
are
two
solving
routes.
Bio-plastics
like
polyhydroxyalkanoates
(PHAs),
polylactic
acid
(PLA),
polycaprolactone
(PCL),
poly
(butylene
succinate)
(PBS),
(ethylene
furanoate)
s
(PEFs)
(PES)
have
emerged
as
promising
alternatives.
Meanwhile,
biodegradation
plays
important
roles
in
recycling
plastics
(e.g.,
bio-plastics
PHAs,
PLA,
PCL,
PBS,
PEFs
PES)
terephthalate)
(PET)
plasticizers
phthalate
esters,
PAEs).
All
these
bio-
petro-materials
show
structure
similarity
by
connecting
monomers
through
ester
bond.
Thus,
this
review
focused
on
summarized
the
sequences
structures
of
microbial
enzymes
catalyzing
ester-bond
synthesis.
Most
synthetic
belonged
α/β-hydrolases
with
conserved
serine
catalytic
active
site
catalyzed
polymerization
forming
For
enzymatic
plastic
degradation,
about
PEFs,
PES
PET
were
discussed,
most
also
α/β
hydrolases
a
residue
serine,
nucleophilically
attacked
bond
substrate
generate
cleavage
backbone.
Enzymes
hydrolysis
representative
plasticizer
PAEs
divided
into
three
types
(I,
II,
III).
Type
I
hydrolyzed
only
one
PAEs,
type
II
mono-ester
phthalates,
III
di-ester
bonds
PAEs.
Divergences
mechanisms
among
still
unclear.
This
provided
references
for
producing
bio-plastics,
or
from
an
point
view.
Biotechnology Advances,
Journal Year:
2023,
Volume and Issue:
69, P. 108264 - 108264
Published: Sept. 27, 2023
Cupriavidus
necator
is
a
bacterium
with
high
phenotypic
diversity
and
versatile
metabolic
capabilities.
It
has
been
extensively
studied
as
model
hydrogen
oxidizer,
well
producer
of
polyhydroxyalkanoates
(PHA),
plastic-like
biopolymers
potential
to
substitute
petroleum-based
materials.
Thanks
its
adaptability
diverse
lifestyles
the
ability
accumulate
large
amounts
PHA,
C.
employed
in
many
biotechnological
processes,
particular
focus
on
PHA
production
from
waste
carbon
sources.
The
availability
genomic
information
enabled
characterization
necator's
metabolism,
leading
establishment
models
which
are
used
devise
optimize
culture
conditions
genetic
engineering
approaches.
In
this
work,
characteristics
available
strains
genomes
reviewed,
underlining
how
thorough
comprehension
variability
lacking
it
could
be
instrumental
for
wider
application
microorganism.
paradigms
they
connected
accumulation
described,
also
recapitulating
variety
substrates
accumulation,
highlighting
most
promising
strategies
increase
yield.
Finally,
review
describes
critically
analyzes
currently
genome-scale
reduced
network
applications
commonly
optimization
production.
Overall,
appears
that
capacity
performing
CO
Journal of Cleaner Production,
Journal Year:
2024,
Volume and Issue:
447, P. 141542 - 141542
Published: March 3, 2024
Polyhydroxyalkanoate
(PHA)
is
a
biodegradable
biopolymer
synthesized
from
renewable
resources,
providing
sustainable
and
eco-friendly
plastics.
The
utilization
of
activated
sludge
for
PHA
production
has
gained
prominence
due
to
its
cost-effectiveness
abundant
availability.
Upscaling
can
contribute
waste
management
resource
recovery
simultaneously,
thereby
reducing
the
dependence
on
petroleum-based
This
review
critically
examines
progress
challenges
in
this
field,
while
offering
valuable
insights
into
strategies
enhancing
productivity,
improving
product
quality,
costs.
analysis
primarily
focuses
identifying
key
factors
influencing
each
stage
three-stage
process
aimed
at
increasing
productivity.
Noteworthy
proposed
include
optimizing
enrichment
feast/famine
ratio.
For
high-quality
PHA,
emphasis
oriented
acid
production,
selection
appropriate
extraction
methods
crucial.
also
addresses
cost
reduction,
discussing
simplification
through
two-stage
process,
integration
nitrogen
removal
with
production.
Future
research
directions
are
outlined,
highlighting
optimization
scalability
development
efficient
methods,
assessment
environmental
impacts,
alignment
policy
measures.
Conclusively,
sludge-based
shows
great
promise
necessitates
further
industrialization.
Sustainability,
Journal Year:
2025,
Volume and Issue:
17(3), P. 820 - 820
Published: Jan. 21, 2025
The
development
of
new
biopolymer
production
technologies
is
becoming
increasingly
relevant
for
tackling
the
negative
impact
linear
plastics.
Despite
these
potential
benefits,
their
and
commercialization
still
face
several
obstacles
that
might
hinder
widespread
adoption.
present
systematic
review
aimed
to
offer
a
thorough
analysis
multi-level
supply-side
barriers
across
researchers,
policymakers,
industry
professionals.
Searches
were
performed
in
Web
Science,
SCOPUS,
PubMed,
IEEE
Xplore
between
June
July
2023.
Publications
2019
2023
considered
(n
=
176).
Content
was
coded
following
PICO
structure
results
reported
PRISMA
checklist.
We
found
technological
knowledge
most
identified,
followed
by
economic,
regulatory,
supply
stability,
behavioral
challenges.
Moreover,
we
82%
documents
identified
more
than
one
barrier,
reflecting
complex
interaction
different
challenges
field.
Fostering
interdisciplinary
collaboration,
establishing
clear
regulatory
frameworks,
enhancing
communication
strategies
are
recommendations
overcoming
barriers.
These
findings
draft
multifaceted
roadmap
key
new,
sustainable
technologies,
carry
significant
implications
future
research,
policy
development,
practices.
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(5), P. 287 - 287
Published: May 22, 2023
Replacement
of
missing
teeth
is
possible
using
biocompatible
devices
such
as
endosseous
implants.
This
study
aims
to
analyze
and
recognize
the
best
characteristics
different
implant
surfaces
that
ensure
good
peri-implant
tissue
healing
thus
clinical
success
over
time.
The
present
review
was
performed
on
recent
literature
concerning
implants
made
titanium,
a
material
most
frequently
used
because
its
mechanical,
physical,
chemical
characteristics.
Thanks
low
bioactivity,
titanium
exhibits
slow
osseointegration.
Implant
are
treated
so
cells
do
not
reject
surface
foreign
accept
it
fully
biocompatible.
Analysis
types
coatings
in
order
identify
ideal
improve
osseointegration,
epithelial
attachment
site,
overall
health.
shows
surface,
with
adhesion,
proliferation,
spreading
capabilities
osteoblastic
cells,
influences
involved
anchorage.
must
have
antibacterial
prevent
disease.
Research
still
needs
minimize
failure.
C – Journal of Carbon Research,
Journal Year:
2023,
Volume and Issue:
9(1), P. 30 - 30
Published: March 7, 2023
Due
to
the
rising
worldwide
demand
for
green
chemicals,
bio-based
polymer
market
is
anticipated
expand
substantially
in
future.
The
synthesis
of
functional
polymers
has
been
a
burgeoning
area
research
decades.
primary
driving
force
behind
development
their
compostability
and
biodegradability,
which
are
critical
given
public
concern
about
waste.
Significant
advancements
method
refining
biomass
raw
materials
towards
creation
construction
products
this
rise.
Bio-based
with
chemical
structure
more
flexible
adaptive,
allows
them
attain
intended
characteristics
functionalities.
In
commercial
applications
healthcare
biotechnology,
where
completely
manufactured,
naturally
occurring
biomolecules
utilized
such
have
greatest
impact.
At
same
time,
limitations
architectural
control,
biostability,
structural
dynamics
hinder
biocompatible
functionally
varied
polymers.
From
standpoint,
importance
biosynthetic
future
years
highlighted,
as
well
new
methods
addressing
aforementioned
challenges.
article
comprehensively
highlighted
current
strategies,
dynamics,
trends
emerging
Bio-Based
Polymers.
addition,
most
recent
scientific
breakthroughs
discussed.
