Catalysts, Journal Year: 2024, Volume and Issue: 14(7), P. 396 - 396
Published: June 21, 2024
The importance of catalysis is obvious and unquestionable, especially bearing in mind that about 90% all commercially produced chemical products involve catalysts at some step their manufacture [...]
Language: Английский
Tetrahedron Green Chem, Journal Year: 2025, Volume and Issue: unknown, P. 100064 - 100064
Published: Jan. 1, 2025
Language: Английский
Citations
0
JACS Au, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Language: Английский
Citations
0
Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: May 9, 2025
This paper describes a novel coordinating activation strategy that enables the synthesis of medium-to-large sized rings (11-17 members) via an unprecedented difluoroalkylamidation cyclization alkynes. method provides efficient platform for accessing skeleton-diverse difluoroalkyl-containing cyclic enamides with complete regio- and stereoselectivity. The protocol features broad substrate compatibility, functional group tolerance, ease use at dilution concentrations (50 mM) are not high. Moreover, synthetic utility this difunctional is underscored by its application in late-stage modification complex molecules. Additionally, click reaction facilitates derivation alkynyl-substituted products, demonstrating methodology's potential biological sciences.
Language: Английский
Citations
0
Polymers, Journal Year: 2023, Volume and Issue: 15(23), P. 4543 - 4543
Published: Nov. 27, 2023
Supramolecular chemistry enables the manipulation of functional components on a molecular scale, facilitating "bottom-up" approach to govern sizes and structures supramolecular materials. Using dynamic non-covalent interactions, polymers can create materials with reversible degradable characteristics abilities self-heal respond external stimuli. Pillar[n]arene represents novel class macrocyclic hosts, emerging after cyclodextrins, crown ethers, calixarenes, cucurbiturils. Its significance lies in its distinctive structure, comparing an electron-rich cavity two finely adjustable rims, which has sparked considerable interest. Furthermore, straightforward synthesis, uncomplicated functionalization, remarkable properties pillar[n]arene based interactions make it excellent candidate for material construction, particularly generating interpenetrating polymers. Polymers resulting from involving find potential various applications, including fluorescence sensors, substance adsorption separation, catalysis, light-harvesting systems, artificial nanochannels, drug delivery. In this context, we provide overview these recent frontier research fields use pillar[n]arene-based polymers, serves as source inspiration creation innovative polymer derived derivatives.
Language: Английский
Citations
7
Organics, Journal Year: 2023, Volume and Issue: 4(3), P. 333 - 363
Published: July 4, 2023
This review is dedicated to the different varieties of macrocycles synthesis bearing indole units in their architecture by metal-catalyzed strategies. The progress new macrocyclization approaches persisted be a keen area research. Macrocycles contain wide variety molecules, and among those, heteroaryl motifs are valuable constituents that provide an attractive feature macrocyclic systems. Indole represents one privileged pharmacophores against targets with various biological applications. Among nitrogen-based heterocycles, plays prominent role organic synthesis, medicinal chemistry, pharmaceuticals, natural products agrochemicals, dye fragrances, drug design. These scaffolds widely distributed several bioactive synthetic constructed specific biochemical target most common naturally occurring molecules. Due its immense importance, novel for indole-based has increased steadily. majority proceeds through macrolactamization macrolactonization, as well C–C bond process described ring-closing metathesis (RCM) coupling reactions. macrocyclizations, considered powerful tools chemists design macrocycles. aims give comprehensive insight into scaffold catalyzed transition metals emerged literature over last two decades. We hope this will persuade search strategies protocols.
Language: Английский
Citations
6
Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: unknown
Published: June 24, 2024
Abstract Macrocycles are essential in protein‐protein interactions and the preferential intake of bioactive scaffolds. commonly synthesized by late‐stage macrolactonizations, macrolactamizations, transition metal‐catalyzed ring‐closing metathesis, S−S bond‐forming reactions, copper‐catalyzed alkyne–azide cycloaddition. Recently, C−H activation strategies have gained significant interest among chemists to synthesize macrocycles. This article provides a comprehensive overview macrocyclization via bond functionalization heterocycle‐containing peptides, annulations, heterocycle‐ring construction through direct functionalization. In first part, palladium salt catalyzed coupling with indolyl C(sp 3 )−H 2 bonds for is reported. The second part summarizes rhodium‐catalyzed macrocyclizations site‐selective Earth‐abundant, less toxic 3d metal Mn‐catalyzed cyclizations reported latter part. summary expected spark emerging methods macrocycle production organic synthesis chemical biology practitioners, helping develop discipline. We hope that this mini‐review will also inspire synthetic explore new broadly applicable C−C intramolecular activation.
Language: Английский
Citations
1
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 8, 2024
Here we report a macrocyclization route towards the synthesis of glycophane peptides by selective C-H arylation anomeric bond. This approach demonstrates power Pd-catalysis activation to access unusual cyclic peptides.
Language: Английский
Citations
1
Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 12(12)
Published: Nov. 10, 2023
Abstract Pivaloyl‐directed Rh(III)‐catalyzed regioselective C7 Ar ‐H functionalization of protected tryptophans were accomplished with 1,4‐benzoquinones, furnishing a series quinone‐appended tryptophan‐based unnatural amino acids in high yields. Further, the late stage on tryptophan‐containing dipeptides was achieved 1,4‐benzoquinones moderate reactivity.
Language: Английский
Citations
2
Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 8, 2024
Abstract Here we report a macrocyclization route towards the synthesis of glycophane peptides by selective C−H arylation anomeric bond. This approach demonstrates power Pd‐catalysis activation to access unusual cyclic peptides.
Language: Английский
Citations
0
Catalysts, Journal Year: 2024, Volume and Issue: 14(7), P. 396 - 396
Published: June 21, 2024
The importance of catalysis is obvious and unquestionable, especially bearing in mind that about 90% all commercially produced chemical products involve catalysts at some step their manufacture [...]
Language: Английский
Citations
0