Antimicrobial Activities of Natural Bioactive Polyphenols

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 718 - 718

Published: May 27, 2024

Secondary metabolites, polyphenols, are widespread in the entire kingdom of plants. They contain one or more hydroxyl groups that have a variety biological functions natural environment. These uses include polyphenols food, beauty products, dietary supplements, and medicinal products grown rapidly during past 20 years. Antimicrobial described together with their sources, classes, subclasses. Polyphenols found different such as dark chocolate, olive oil, red wine, almonds, cashews, walnuts, berries, green tea, apples, artichokes, mushrooms, etc. Examples benefits antiallergic, antioxidant, anticancer agents, anti-inflammatory, antihypertensive, antimicrobe properties. From these classes helpful for growth internal functional systems human body, providing healthy fats, vitamins, minerals, lowering risk cardiovascular diseases, improving brain health, rebooting our cellular microbiome health by mitochondrial uncoupling. Among various (curcumin, naringenin, quercetin, catechin, etc.) primarily antimicrobial activities discussed along possible future applications. For agents to be proven safe, adverse impacts must substantiated reliable scientific research well vitro vivo clinical data. Future may influenced this evaluation.

Language: Английский

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Synthesis and physicochemical properties of an aromatic chitosan derivative: In vitro antibacterial, antioxidant, and anticancer evaluations, and in silico studies

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 240, P. 124339 - 124339

Published: April 6, 2023

Language: Английский

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Biocatalytic enzymes in food packaging, biomedical, and biotechnological applications: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140069 - 140069

Published: Jan. 1, 2025

Language: Английский

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Antidiabetic Effects of Quercetin and Silk Sericin in Attenuating Dysregulation of Hepatic Gluconeogenesis in Diabetic Rats Through Potential Modulation of PI3K/Akt/FOXO1 Signaling: In Vivo and In Silico Studies

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(1), P. 16 - 16

Published: Jan. 19, 2025

Type 2 diabetes mellitus (T2DM) is an intricate disease correlated with many metabolic deregulations, including disordered glucose metabolism, oxidative stress, inflammation, and cellular apoptosis due to hepatic gluconeogenesis aberrations. However, there no radical therapy inhibit disturbances yet. We thus sought probe the effectiveness uncover potential mechanism of quercetin (QCT) silk sericin (SS) in mitigating hyperglycemia-induced disorder, which remains obscure. Administration QCT SS diabetic male albino rats markedly restored levels glucose, insulin, advanced glycation end-products (AGEs), liver function enzymes, alpha-fetoprotein (AFP), globulin, glycogen, addition carbohydrate metabolizing enzymes comparison rats. Furthermore, treatment modulated malondialdehyde (MD), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx), nitric oxide, tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), serum interleukin-6 (IL-6) cyclooxygenase-2 (COX-2), implying their safeguarding cells against impairment inflammation. Remarkably, treatments led upregulation expression phosphatidylinositol 3-kinases (PI3K), phospho-Akt (p-Akt), forkhead box-O1 (FOXO1) genes tissues compared rats, orchestrating these singling pathways for curtailing hyperglycemia pernicious consequences tissues. Importantly, immunohistochemical investigations exhibited downregulation caspase-3 treated animals. Beyond that, histopathological results demonstrated notable correlations biochemical findings. Interestingly, silico supported vivo findings, showing binding affinities PI3K, GPx, TNF-α proteins. These imply that could mitigate stress inflammation regulate revealed greater molecular interactions studied proteins than SS. Overall, our emphasize have significant therapeutic effects on attenuating gluconeogenesis, superior effectiveness.

Language: Английский

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Plant Polyphenols as Heart’s Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 915 - 915

Published: Jan. 22, 2025

Polyphenols are micronutrients found in fruits, vegetables, tea, coffee, cocoa, medicinal herbs, fish, crustaceans, and algae. They can also be synthesized using recombinant microorganisms. Interest plant-derived natural compounds has grown due to their potential therapeutic effects with minimal side effects. This is particularly important as the aging population faces increasing rates of chronic diseases such cancer, diabetes, arthritis, cardiovascular, neurological disorders. Studies have highlighted polyphenols’ capacity reduce risk factors linked onset illnesses. narrative review discusses polyphenol families metabolism, cardioprotective polyphenols evidenced from vitro studies, well vivo on different animal models cardiac disease. study explores molecular mechanisms underlying these benefits. Current research suggests that may protect against ischemia, hypertension, hypertrophy, heart failure, myocardial injury through complex mechanisms, including epigenetic genomic modulation. However, further studies under nutritionally physiologically relevant conditions, untargeted multigenomic approaches, needed more comprehensively elucidate firmly prove polyphenols.

Language: Английский

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Anti-Inflammatory and Antioxidant Effects of White Grape Pomace Polyphenols on Isoproterenol-Induced Myocardial Infarction

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2035 - 2035

Published: Feb. 26, 2025

Grape pomace (GP), the residue left after grape pressing in winemaking, is rich polyphenols, including flavonoids, tannins, and phenolic acids, which have antioxidant anti-inflammatory properties. The present study aimed to evaluate cardioprotective effects of white (WGP) extract two concentrations polyphenols (795 mg from WGP/kg body weight (bw) 397.5 bw)), on isoproterenol (ISO)-induced myocardial infarction (MI), focusing its effects. White administration for 14 days offered a cardio-protective effect prevented prolongation QT QTc intervals electrocardiogram. Both WGP elevation nitric oxide (NO) malondialdehyde (MDA) serum, with best results being observed highest concentration (p < 0.05). reduction pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), 1β (IL-1β) both serum tissue dose-dependent manner, having Moreover, reduced histological changes associated MI. findings demonstrate that exerts cardio protective by reducing MI-associated inflammation oxidative stress.

Language: Английский

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The Synergistic Influence of Polyflavonoids from Citrus aurantifolia on Diabetes Treatment and Their Modulation of the PI3K/AKT/FOXO1 Signaling Pathways: Molecular Docking Analyses and In Vivo Investigations

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2306 - 2306

Published: Sept. 12, 2023

This study was aimed at probing the modulatory influence of polyflavonoids extracted from Citrus aurantifolia, lemon peel extract (LPE-polyflavonoids), on attenuating diabetes mellitus (DM) and its complications. HPLC investigations LPE exhibited incidence five flavonoids, including diosmin, biochanin A, hesperidin, quercetin, hesperetin. The in silico impact ligand-phosphatidylinositol 3-kinase (PI3K) interaction investigated terms polyflavonoid class to explore non-covalent intakes binding affinity known protein active site. drug likeness properties pharmacokinetic parameters LPE-polyflavonoids were assess their bioavailability relation Myricetin as a control. Remarkably, molecular docking studies demonstrated prominent score all these agents together with PI3K, implying potency orchestrate which is predominant signal for lessening level blood glucose. To verify findings, vivo conducted, utilizing diabetic male albino rats treated other groups hesperidin diosmin single flavonoids. Our findings that significantly ameliorated levels glucose, insulin, glycogen, liver function, carbohydrate metabolizing enzymes, G6Pd, AGEs compared those exposed diosmin. Furthermore, regulated TBARS, GSH, CAT, TNF-α, IL-1β, IL-6, AFP pancreatic hepatic tissues, suggesting antioxidant anti-inflammatory properties. In addition, GLUT4 GLUT2 noticeably increased addition p-AKT administered rats. administration upregulated expression AMPK, FOXO1 genes, emphasizing efficiency orchestrating signaling pathways necessitated reduce mellitus. Notably, histopathological examinations tissues corroborated biochemical results. Altogether, our accentuated potential therapeutic role controlling

Language: Английский

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Preparation, characterization, and pharmacological application of oral Honokiol-loaded solid lipid nanoparticles for diabetic neuropathy

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 645, P. 123399 - 123399

Published: Sept. 11, 2023

Language: Английский

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Efficacy of propolis and royal jelly in attenuating cadmium-induced spermatogenesis and steroidogenesis dysregulation, causing infertility in rats

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(40), P. 53052 - 53073

Published: Aug. 22, 2024

Language: Английский

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Liquid chromatography-mass spectrometry profiling of propolis and royal jelly and their ameliorative effects on cadmium-instigated pathological consequences in ovarian tissues of rats

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111800 - 111800

Published: Sept. 1, 2024

Language: Английский

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