Review on Contemporary Synthetic Recipes to Access Versatile Coumarin Heterocycles

Polycyclic aromatic compounds, Journal Year: 2023, Volume and Issue: 44(5), P. 3576 - 3600

Published: July 21, 2023

Coumarin and its derivatives are extensively used as scaffolds in the synthesis of novel heterocyclic motifs. In literature, several approaches especially involving metal metal-free catalysts have been developed to get biological potential coumarin analogs. This review spotlights recent advancements associated molecules recounting literature articles from 2015 middle 2022. Further, this review, we focused on contents based classical non-classical methods for synthesis.

Language: Английский

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A Comprehensive Review of Magnetic Nanocatalysts for C−S, C−Se Bond Formation

ChemistryOpen, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract This review manuscript examines magnetic nanocatalysts and their pivotal role in forming carbon‐sulfur (C−S) carbon‐selenium (C−Se) bonds. The study delves into the latest advancements synthesis, characterization, application of nanocatalysts, highlighting unique advantages, including enhanced catalytic activity, superior selectivity, easy recovery through separation, which align with principles green chemistry. Through a critical analysis recent research findings, this also explores mechanistic pathways facilitated by these offering insights operational efficiency potential for recyclability. aims not only to catalog current achievements burgeoning field but identify challenges propose future directions developing more efficient, sustainable, versatile systems C−S C−Se bond formation. By encompassing broad spectrum ranging from bare magnets functionalized composite materials, is comprehensive resource researchers engaged organic catalysis, sustainable

Language: Английский

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Recent Approaches in Transition Metal-Catalyzed Chalcogenative Heteroannulation of Alkenes and Alkynes

Catalysts, Journal Year: 2023, Volume and Issue: 13(9), P. 1300 - 1300

Published: Sept. 16, 2023

Organochalcogen-bearing heterocycles are important scaffolds in compounds under the spotlight of scientific interest optoelectronic fields and for biological applications. The use transition metals has been a versatile reliable way to carry out synthesis these molecules efficiently, delivering products high yields with wide functional diversity. In last 10 years, many classes have synthesized cyclization reaction acyclic alkenes alkynes incorporation chalcogen atom on its structure. Transition metal catalysts including Cu, Co, Pd, Ni, In, Ag, Fe salts used development new methodologies, expansion substrate scope, mechanistic studies. This review provides an overview recent approaches aim being useful resource interested researchers this area.

Language: Английский

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Synthesis, structural characterization of phenoxo-bridged zinc(II) complexes and their binding interaction with the spike protein of SARS-CoV-2

Phosphorus, sulfur, and silicon and the related elements, Journal Year: 2024, Volume and Issue: 199(5), P. 406 - 419

Published: May 3, 2024

The research article reports the synthesis and structural study of optimized geometry selenium (Se) bearing 24- 28- membered macrocyclic Schiff bases, LaH2, LbH2 their reactions with zinc metal ion. bases ZnCl2 in 1:2 molar ratios result formation bimetallic Zn(II) complexes having molecular composition [Se{(CH2)2N = CPh(4-CH3-C6H2O) PhC O}2 · Zn2Cl2], (1) [Se{(CH2)3N CPh(4-CH3-C6H2O)PhC (2). Moreover, as confirmed by various physico-chemical techniques such elemental analysis, UV–Vis, FTIR,1H NMR, mass spectrometry, proligands underwent partial hydrolytic cleavage at one C N positions behave like hexadentate (N2O4) ligands binding to two ions via bridging through Ophenolic atoms, which results a square pyramidal around chlorine atom occupying axial positions. Further, following density functional study, stable configuration LaH2 is found adopt bowl shape geometry. Conversely, docking studies, synthesized complex 1 exhibits significantly stronger affinity (−8.7 kcal/mol) spike protein Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) compared common coronavirus disease 2019 (COVID-19) treatment drugs chloroquine, hydroxychloroquine, remdesivir activity percentage showing more than 20% overall effectiveness thus indicating its potential for COVID-19 therapeutics.

Language: Английский

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Green synthesis of organometallic compounds and their medicinal aspects

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 433 - 448

Published: Jan. 1, 2024

Language: Английский

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Selenylated Analogs of Tacrine: Synthesis, in Silico and in Vitro Studies of Toxicology and Antioxidant Properties

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

We present our results on the synthesis and preliminary in silico vitro studies of toxicology antioxidant properties selenylated analogs Tacrine. Initially, we synthesized 2-aminobenzonitriles containing an organic selenium moiety, resulting sixteen compounds with various substituents linked to portion derived from diorganyl diselenide. These were then used as substrates reactions cyclic ketones, presence 1.4 equivalents trifluoroboroetherate a Lewis acid, synthesize Tacrine yields ranging 20 % 87 %. In explored computational parameters related activity hepatotoxicity. elucidated effects its hybrid (TSe) neutralizing ABTS radicals, scavenging DPPH reducing iron ions. Additionally, acute oral toxicity one compound was evaluated.

Language: Английский

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Visible light–driven organic synthesis under Eosin Y photocatalysis

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 91 - 149

Published: Aug. 16, 2024

Language: Английский

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