Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(4), P. 533 - 548.e12

Published: March 18, 2022

Language: Английский

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Mitochondria-associated programmed cell death as a therapeutic target for age-related disease

Experimental & Molecular Medicine, Journal Year: 2023, Volume and Issue: 55(8), P. 1595 - 1619

Published: Aug. 23, 2023

Abstract Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate. Evidence has shown mitochondria as points of convergence for diverse death-inducing pathways that trigger the various mechanisms underlying apoptotic and nonapoptotic programmed death. Thus, dysfunctional eventually lead or contribute to age-related diseases, such neurodegenerative, cardiovascular diseases. mitochondrion-associated death-based treatments show great therapeutic potential, providing novel insights in clinical trials. This review discusses mitochondrial quality control networks with activity triggered by stimuli maintain homeostasis via mitohormesis, unfolded protein response, mitophagy. The also presents details on forms mitochondria-associated death, including apoptosis, necroptosis, ferroptosis, pyroptosis, parthanatos, paraptosis, highlights their involvement disease pathogenesis, collectively suggesting directions further research.

Language: Английский

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AMPK/PPAR-γ/NF-κB axis participates in ROS-mediated apoptosis and autophagy caused by cadmium in pig liver

Environmental Pollution, Journal Year: 2021, Volume and Issue: 294, P. 118659 - 118659

Published: Dec. 8, 2021

Language: Английский

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Anti-Obesity Effects of Metformin: A Scoping Review Evaluating the Feasibility of Brown Adipose Tissue as a Therapeutic Target

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2227 - 2227

Published: Jan. 23, 2023

Brown adipose tissue (BAT) is increasingly recognized as the major therapeutic target to promote energy expenditure and ameliorate diverse metabolic complications. There a general interest in understanding pleiotropic effects of metformin against Major electronic databases search engines such PubMed/MEDLINE, Google Scholar, Cochrane library were used retrieve critically discuss evidence reporting on impact regulating BAT thermogenic activity complications linked with obesity. The summarized suggests that can reduce body weight, enhance insulin sensitivity, improve glucose metabolism by promoting preclinical models Notably, this anti-diabetic agent affect expression transcriptional factors uncoupling protein 1 (UCP1), nuclear respiratory factor (NRF1), peroxisome-proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α) mitochondrial function expenditure. Interestingly, vital molecular markers involved regulation AMP-activated kinase (AMPK) fibroblast growth 21 (FGF21) are similarly upregulated treatment current review also discusses clinical relevance thermogenesis targets. This explored critical components including effective dosage appropriate intervention period, consistent beneficial obesity-associated

Language: Английский

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Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 4, 2024

Obesity presents a significant global health challenge, increasing the susceptibility to chronic conditions such as diabetes, cardiovascular disease, and hypertension. Within context of obesity, lipid metabolism, adipose tissue formation, inflammation are intricately linked endoplasmic reticulum stress (ERS). ERS modulates insulin signaling, inflammation, well cell proliferation death through unfolded protein response (UPR) pathway. Serving crucial nexus, bridges functionality inflammatory response. In this review, we comprehensively elucidate mechanisms by which impacts function in aiming offer insights into targeting for ameliorating metabolic dysregulation obesity-associated diseases hyperlipidemia, hypertension, fatty liver, type 2 diabetes.

Language: Английский

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UCP1 activation: Hottest target in the thermogenesis pathway to treat obesity using molecules of synthetic and natural origin

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 28(9), P. 103717 - 103717

Published: July 18, 2023

Language: Английский

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Anthocyanins and their metabolites promote white adipose tissue beiging by regulating mitochondria thermogenesis and dynamics

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 222, P. 116069 - 116069

Published: Feb. 20, 2024

Language: Английский

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The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue

Biomolecules, Journal Year: 2021, Volume and Issue: 11(12), P. 1757 - 1757

Published: Nov. 24, 2021

Obesity is characterized by excessive accumulation of fat in the body, which triggered a body energy intake larger than consumption. Due to complications such as cardiovascular diseases, type 2 diabetes (T2DM), obstructive pneumonia and arthritis, well high mortality, morbidity economic cost, obesity has become major health problem. The global prevalence obesity, its comorbidities escalating at alarming rates, demanding development additional classes therapeutics reduce burden disease further. As central sensor, AMP-activated protein kinase (AMPK) recently been elucidated play paramount role synthesis catabolism, especially regulating expenditure brown/beige adipose tissue browning white (WAT). This review discussed AMPK metabolism tissue, emphasizing WAT. A deeper understanding can provide new insights into research treatment.

Language: Английский

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AMP‐activated protein kinase activation in skeletal muscle modulates exercise‐induced uncoupled protein 1 expression in brown adipocyte in mouse model

The Journal of Physiology, Journal Year: 2022, Volume and Issue: 600(10), P. 2359 - 2376

Published: March 18, 2022

Abstract Aerobic exercise is an effective intervention in preventing obesity and also important factor associated with thermogenesis. There increasing interest the factors mechanisms induced by aerobic that can influence metabolism thermogenic activity individual. Recent studies suggest circulating (known as ‘exerkines’), which are able to modulate activation of brown adipose tissue (BAT) browning white tissue. However, underlying molecular effect exercise‐induced peripheral on BAT remain poorly understood. Furthermore, role training still debatable. Hence, purpose our study assess whether affects expression uncoupled protein 1 (UCP1) adipocytes via release different blood factors. Four weeks significantly decreased body weight gain fat mass gain. trained mice exhibit higher levels energy expenditure UCP1 than untrained mice. Surprisingly, treatment serum from exercise‐trained increased differentiated adipocytes. To a better understanding these mechanisms, we analysed conditioned media obtained after treating C2C12 myotubes AMP‐activated kinase (AMPK) activator (AICAR; 5‐aminoimidazole‐4‐carboxamide ribonucleotide), leads when added Our observations possibility AMPK skeletal muscles. Key points Exercise promotes thermogenesis activating uncoupling (UCP1), decrease content. little known about exerkines modulating subsequent activation. voluntary wheel‐running reduces induces increase slow‐type muscle fibre marker genes muscles tissues. Incubation isolated their gene levels; moreover, AMPK‐activator‐treated These results show has significant BAT.

Language: Английский

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Mitochondrial UCP1: Potential thermogenic mechanistic switch for the treatment of obesity and neurodegenerative diseases using natural and epigenetic drug candidates

Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155672 - 155672

Published: May 4, 2024

Language: Английский

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