Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
74, P. 101760 - 101760
Published: June 24, 2023
Medium
chain
fatty
acids
(MCFAs),
which
are
with
lengths
of
8-12
carbon
atoms,
have
been
shown
to
reduce
food
intake
in
rodents
and
humans,
but
the
underlying
mechanisms
unknown.
Unlike
most
other
acids,
MCFAs
absorbed
from
intestine
into
portal
vein
enter
first
liver.
We
thus
hypothesized
that
trigger
release
hepatic
factors
appetite.The
liver
transcriptome
mice
were
orally
administered
as
C8:0
triacylglycerol
(TG)
was
analyzed.
Circulating
growth/differentiation
factor
15
(GDF15),
tissue
Gdf15
mRNA
investigated
after
acute
oral
gavage
or
C10:0
TG
mice.
Effects
subchronic
administration
on
body
weight
determined
lacking
either
receptor
for
GDF15,
GDNF
Family
Receptor
Alpha
Like
(GFRAL),
GDF15.Hepatic
small
intestinal
expression
circulating
GDF15
increased
ingestion
MCFAs,
while
typical
dietary
long-chain
(LCFAs)
had
no
effect.
Plasma
levels
also
MCFA
intake,
indicating
addition
liver,
contributes
rise
GDF15.
Acute
provision
decreased
over
24
h
compared
a
LCFA-containing
bolus,
this
anorectic
effect
required
receptor,
GFRAL.
Moreover,
reduced
7
days,
an
blunted
GFRAL.We
identified
novel
nutritional
approach
increases
revealed
GDF15-GFRAL
axis
is
full
MCFAs.
Respiratory Research,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: May 9, 2024
Abstract
Growth
differentiation
factor
15
(GDF15)
as
a
stress
response
cytokine
is
involved
in
the
development
and
progression
of
several
diseases
associated
with
metabolic
disorders.
However,
regulatory
role
underlying
mechanisms
GDF15
sepsis
remain
poorly
defined.
Our
study
analyzed
levels
its
correlations
clinical
prognosis
patients
sepsis.
In
vivo
vitro
models
were
applied
to
elucidate
sepsis-associated
lung
injury.
We
observed
strong
plasma
C-reactive
protein
(CRP),
procalcitonin
(PCT),
lactate
dehydrogenase
(LDH),
well
Sequential
Organ
Failure
Assessment
(SOFA)
scores
mouse
model
lipopolysaccharide-induced
sepsis,
recombinant
inhibited
proinflammatory
responses
alleviated
tissue
addition,
decreased
cytokines
produced
by
alveolar
macrophages
(AMs).
The
anti-inflammatory
effect
glycolysis
inhibitor
2-DG
on
AMs
during
was
mediated
via
inducing
phosphorylation
α-subunit
eukaryotic
initiation
2
(eIF2α)
expression
activating
transcription
4
(ATF4).
Furthermore,
we
explored
mechanism
beneficial
effects
found
that
mitogen-activated
kinases
(MAPK)/nuclear
factor-κB
(NF-κB)
signaling
promoting
AMPK
phosphorylation.
This
demonstrated
NF-κB/MAPKs
AMP-activated
kinase
(AMPK),
thereby
alleviating
inflammatory
findings
provided
new
insights
into
novel
therapeutic
strategies
for
treating
Journal of Cachexia Sarcopenia and Muscle,
Journal Year:
2024,
Volume and Issue:
15(4), P. 1549 - 1557
Published: June 18, 2024
Growth
differentiation
factor-15
(GDF-15)
has
been
associated
with
senescence,
lower
muscle
strength,
and
physical
performance
in
healthy
older
people.
Still,
it
is
not
clear
whether
GDF-15
can
be
utilized
as
a
biomarker
of
sarcopenia
frailty
the
early
stages
hospitalization.
We
investigated
association
plasma
older,
acutely
admitted
medical
patients.
EMBO Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
15(7)
Published: May 24, 2023
Abstract
Mitochondrial
diseases
are
a
heterogeneous
group
of
monogenic
disorders
that
result
from
impaired
oxidative
phosphorylation
(OXPHOS).
As
neuromuscular
tissues
highly
energy‐dependent,
mitochondrial
often
affect
skeletal
muscle.
Although
genetic
and
bioenergetic
causes
OXPHOS
impairment
in
human
myopathies
well
established,
there
is
limited
understanding
metabolic
drivers
muscle
degeneration.
This
knowledge
gap
contributes
to
the
lack
effective
treatments
for
these
disorders.
Here,
we
discovered
fundamental
remodeling
mechanisms
shared
by
disease
patients
mouse
model
myopathy.
triggered
starvation‐like
response
evokes
accelerated
oxidation
amino
acids
through
truncated
Krebs
cycle.
While
initially
adaptive,
this
evolves
an
integrated
multiorgan
catabolic
signaling,
lipid
store
mobilization,
intramuscular
accumulation.
We
show
feed‐forward
involves
leptin
glucocorticoid
signaling.
study
elucidates
systemic
dyshomeostasis
underlie
identifies
potential
new
targets
intervention.
Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
74, P. 101760 - 101760
Published: June 24, 2023
Medium
chain
fatty
acids
(MCFAs),
which
are
with
lengths
of
8-12
carbon
atoms,
have
been
shown
to
reduce
food
intake
in
rodents
and
humans,
but
the
underlying
mechanisms
unknown.
Unlike
most
other
acids,
MCFAs
absorbed
from
intestine
into
portal
vein
enter
first
liver.
We
thus
hypothesized
that
trigger
release
hepatic
factors
appetite.The
liver
transcriptome
mice
were
orally
administered
as
C8:0
triacylglycerol
(TG)
was
analyzed.
Circulating
growth/differentiation
factor
15
(GDF15),
tissue
Gdf15
mRNA
investigated
after
acute
oral
gavage
or
C10:0
TG
mice.
Effects
subchronic
administration
on
body
weight
determined
lacking
either
receptor
for
GDF15,
GDNF
Family
Receptor
Alpha
Like
(GFRAL),
GDF15.Hepatic
small
intestinal
expression
circulating
GDF15
increased
ingestion
MCFAs,
while
typical
dietary
long-chain
(LCFAs)
had
no
effect.
Plasma
levels
also
MCFA
intake,
indicating
addition
liver,
contributes
rise
GDF15.
Acute
provision
decreased
over
24
h
compared
a
LCFA-containing
bolus,
this
anorectic
effect
required
receptor,
GFRAL.
Moreover,
reduced
7
days,
an
blunted
GFRAL.We
identified
novel
nutritional
approach
increases
revealed
GDF15-GFRAL
axis
is
full
MCFAs.
