Deleted Journal,
Journal Year:
2022,
Volume and Issue:
1(2), P. 587 - 604
Published: Nov. 8, 2022
Biopolymers,
including
extracellular
matrix
proteins
and
polysaccharides,
are
used
as
substrates
for
cell
culture
scaffolds
in
tissue
engineering.
Ionizing
radiation,
example
with
gamma
rays
or
electron
beams,
is
to
sterilize
materials
modify
the
physical
chemical
properties
of
materials.
The
principles
effect
ionizing
radiation
on
biopolymers
discussed
this
review
article.
Among
types
beams
widely
biomaterials
construct
medical
devices.
Water
molecules
split
by
irradiation
give
hydrated
electrons,
proton
radicals
hydroxyl
radicals.
These
reactive
molecular
species
react
polymer
chains
provoke
scission
crosslinking
reactions.
Both
can
occur,
depending
conditions.
Sterilization
necessary
if
they
devices
implants.
advantages
disadvantages
comparison
other
methods
sterilization
also
discussed.
Irradiations
strong
three
biopolymers—Type
I
collagen,
wool
keratin
alginate—are
described
examples
biopolymers.
a
very
useful
tool
sterilizing
constructing
devices,
but
it
important
that
we
know
its
merits
demerits,
well
limitations,
safety
risks,
applications.
Environment International,
Journal Year:
2024,
Volume and Issue:
185, P. 108535 - 108535
Published: Feb. 27, 2024
Ultraviolet
(UV)
radiation
is
ubiquitous
in
the
environment,
which
has
been
classified
as
an
established
human
carcinogen.
As
largest
and
outermost
organ
of
body,
direct
exposure
skin
to
sunlight
or
UV
can
result
sunburn,
inflammation,
photo-immunosuppression,
photoaging
even
cancers.
To
date,
there
are
tactics
protect
by
preventing
reducing
amount
skin.
Nevertheless,
deciphering
essential
regulatory
mechanisms
may
pave
way
for
therapeutic
interventions
against
UV-induced
disorders.
Additionally,
light
considered
beneficial
specific
skin-related
conditions
medical
therapy.
Recent
evidence
indicates
that
biological
effects
extend
beyond
include
treatment
inflammatory
diseases,
solid
tumors
certain
abnormal
behaviors.
This
review
mainly
focuses
on
Moreover,
novel
findings
other
organs
systems
also
summarized.
through
affects
organism
remain
be
fully
elucidated
achieve
a
more
comprehensive
understanding
its
effects.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(37)
Published: March 17, 2024
Abstract
The
emergence
of
metamaterials
and
their
continued
prosperity
have
built
a
powerful
working
platform
for
accurately
manipulating
the
behavior
electromagnetic
waves,
providing
sufficient
possibility
realization
metamaterial
absorbers
with
outstanding
performance.
However,
composed
metallic
materials
typically
possess
many
unfavorable
factors,
such
as
non‐adjustable
absorption,
easy
oxidation,
low‐melting,
expensive
preparation
costs.
selection
dielectric
provides
excellent
alternatives
due
to
remarkable
properties,
thus
dielectric‐based
(DBMAs)
attracted
much
attention.
To
promote
breakthroughs
in
DBMAs
guide
future
development,
this
work
systematically
deeply
reviews
recent
research
progress
from
four
different
but
progressive
aspects,
including
physical
principles;
classifications,
material
selections
tunable
properties;
technologies;
functional
applications.
Five
types
theories
related
mechanisms,
Mie
resonance,
guided‐mode
Anapole
are
briefly
outlined
explain
having
near‐perfect
absorption
Mainstream
selections,
structure
designs,
highlighted.
Several
widely
utilized
methods
customizing
given.
Various
practical
applications
sensing,
stealth
technology,
solar
energy
interference
suppression
reviewed.
Finally,
some
key
challenges
feasible
solutions
DBMAs’
development
provided.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(2), P. 1289 - 1324
Published: Jan. 2, 2024
A
significant
amount
of
progress
in
nanotechnology
has
been
made
due
to
the
development
engineered
nanoparticles.
The
use
metallic
nanoparticles
for
various
biomedical
applications
extensively
investigated.
Biomedical
research
is
highly
focused
on
them
because
their
inert
nature,
nanoscale
structure,
and
similar
size
many
biological
molecules.
intrinsic
characteristics
these
particles,
including
electronic,
optical,
physicochemical,
surface
plasmon
resonance,
that
can
be
altered
by
altering
size,
shape,
environment,
aspect
ratio,
ease
synthesis,
functionalization
properties,
have
led
numerous
applications.
Targeted
drug
delivery,
sensing,
photothermal
photodynamic
therapy,
imaging
are
some
these.
promising
clinical
results
NBTXR3,
a
high-Z
radiosensitizing
nanomaterial
derived
from
hafnium,
demonstrated
translational
potential
this
metal.
This
radiosensitization
approach
leverages
dependence
energy
attenuation
atomic
number
enhance
energy-matter
interactions
conducive
radiation
therapy.
High-Z
nanoparticle
localization
tumor
issue
differentially
increases
effect
ionizing
cancer
cells
versus
nearby
healthy
ones
mitigates
adverse
effects
reducing
overall
burden.
principle
enables
material
multifunctionality
as
contrast
agents
X-ray-based
imaging.
physiochemical
properties
hafnium
(Z
=
72)
particularly
advantageous
well-placed
K-edge
absorption
high
mass
coefficient
compared
elements
human
tissue
across
ranges
leads
attenuation.
Chemical
reactivity
allows
variety
composition,
functionalization.
Nanoparticles
such
oxide
exhibit
excellent
biocompatibility
inertness
prior
incidence
with
radiation.
Additionally,
optical
electronic
applicable
biosensing,
component
coatings,
semiconductors.
wide
interest
prompted
extensive
design
synthesis
facilitate
property
fine-tuning.
review
summarizes
synthetic
methods
hafnium-based
nanomaterials
imaging,
biosensing
mechanistic
focus.
discussion
future
perspective
section
highlights
elaborates
current
challenges.
By
focusing
factors
impacting
applicational
effectiveness
examining
limitations
aims
support
researchers
expedite
translation
nanomedicine.
Molecular Biology Reports,
Journal Year:
2024,
Volume and Issue:
51(1)
Published: July 22, 2024
Diabetic
foot
ulcers
(DFU)
are
a
debilitating
and
life-threatening
complication
of
Diabetes
Mellitus.
Ulceration
develops
from
combination
associated
diabetic
complications,
including
neuropathy,
circulatory
dysfunction,
repetitive
trauma,
they
affect
approximately
19-34%
patients
as
result.
The
severity
chronic
nature
stems
the
disruption
to
normal
wound
healing,
result
molecular
mechanisms
which
underly
pathophysiology.
current
standard-of-care
is
clinically
insufficient
promote
healing
for
many
DFU
patients,
resulting
in
high
frequency
recurrence
limb
amputations.
Biomaterial
dressings,
particular
those
derived
extracellular
matrix
(ECM),
have
emerged
promising
approach
treatment
DFU.
By
providing
template
cell
infiltration
skin
regeneration,
ECM-derived
biomaterials
offer
great
hope
A
range
approaches
exist
development
biomaterials,
use
purified
ECM
components,
decellularisation
processing
donor/
animal
tissues,
or
vitro-deposited
ECM.
This
review
discusses
assessment
wounds,
well
action
through
stimulate
healing.
Acta Biomaterialia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Biological
tissues
are
exposed
to
X-rays
in
medical
applications
(such
as
diagnosis
and
radiotherapy)
research
studies
(for
example
microcomputed
X-ray
tomography:
microCT).
Radiotherapy
may
deliver
doses
up
50Gy
both
tumour
healthy
tissues,
resulting
undesirable
clinical
side
effects
which
can
compromise
quality
of
life.
Whilst
cellular
responses
relatively
well-characterised,
X-ray-induced
structural
damage
the
extracellular
matrix
(ECM)
is
poorly
understood.
This
study
tests
hypotheses
that
ECM
proteins
ECM-rich
(purified
collagen
I
rat
tail
tendons
respectively)
structurally
compromised
by
exposure
used
breast
radiotherapy.
Protein
gel
electrophoresis
demonstrated
radiotherapy
equivalent
induce
fragmentation
constituent
α
chains
solubilised
purified
I.
However,
assembly
into
fibrils,
either
vitro
or
vivo,
prevented
but
not
changes
(as
characterised
LC-MS/MS
peptide
location
fingerprinting:
PLF).
In
subsequent
experiments
higher
(synchrotron)
induced
substantial
fibrillar
(chicken
tendon)
PLF
analysis
synchrotron-irradiated
tendon
identified
structure-associated
collagens
I,
VI,
XII,
proteoglycans
including
aggrecan,
decorin,
fibromodulin,
elastic
fibre
component
fibulin-1.
Thus,
affect
structure
key
tissue
components,
although
additional
will
be
required
understand
dose
dependent
effects.
STATEMENT
OF
SIGNIFICANCE:
systems
routinely
during
treatments
(radiotherapy)
imaging
(microCT).
impact
ionising
radiation
on
cells
well
interactions
between
not.
Here,
we
show
low
sufficient
its
forms.
Although
intermediate
was
determined,
high
exposures
achievable
using
a
synchrotron
source
had
an
even
greater
effect
molecules
and,
tendon,
structures
many
accessory
proteins,
The
unwanted
therefore
due
only
also
surrounding
matrix.
Frontiers in Surgery,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 3, 2025
At
present,
consensus
on
the
management
of
female
stress
urinary
incontinence
(SUI)
after
pelvic
radiotherapy
is
lacking.
We
aim
to
assess
clinical
effects
mid-urethral
sling
(MUS)
for
treatment
SUI
in
women.
conducted
a
retrospective
review
database
with
from
June
2015
February
2022.
The
efficacy
was
evaluated
by
International
Consultation
Incontinence
Questionnaire-Short
Form
(ICI-Q-SF)
questionnaire,
maximum
flow
rate
(Qmax)
and
postvoid
residual
(PVR)
urine.
All
patients
were
reviewed
postoperatively
an
outpatient
clinic.
identified
26
mean
age
59.35
±
7.32
years.
who
suffered
had
history
gynaecological
malignancies
received
radiotherapy.
21
(80.77%,
95%
CI:
0.621-0.915)
considered
have
successfully
improved
surgery,
ICI-Q-SF
scores
lower
than
pre-operative
at
2
weeks,
6
months
1
year
(P
<
0.01).
After
1-year
follow-up,
none
mesh
erosion.
following
malignancy
can
be
challenging
manage.
MUS
highly
effective
safe
option
radiotherapy,
additionally,
that
proper
tension
key
success
procedure.
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(1), P. 194 - 194
Published: Jan. 17, 2025
Radiation-induced
skin
toxicity,
resulting
from
ionizing
or
nonionizing
radiation,
is
a
common
disorder.
However,
the
underlying
relationship
between
microbiota
and
radiation-induced
toxicity
remains
largely
unexplored.
Herein,
we
uncover
microbiota–skin
interaction
based
on
genome-wide
association
study
(GWAS)
featuring
150
three
types
of
microenvironment.
Summary
datasets
human
were
extracted
GWAS
catalog
database,
summary
FinnGen
biobank.
Mendelian
Randomization
(MR)
analysis
was
leveraged
to
sort
out
causal
link
toxicity.
We
identified
33
connections
including
19
positive
14
negative
causative
directions.
Among
these
potential
associations,
genus
Staphylococcus
could
serve
as
risk
factor
for
especially
radiodermatitis.
And
Streptococcus
salivarius
protective
against
Additional
indicated
no
pleiotropy,
heterogeneity,
reverse
in
results.
comprehensively
assessed
associations
with
several
suggestive
links.
Our
results
provide
promising
targets
prevention
treatment
Radiation-induced
skin
injury
(RSI)
presents
a
significant
challenge
in
wound
care
due
to
its
complex
pathophysiology,
which
includes
increased
oxidative
stress,
impaired
angiogenesis,
and
delayed
re-epithelialization.
Transcriptomic
analysis
reveals
alterations
genes
associated
with
the
ferroptosis
pathway
following
radiation
exposure.
In
this
study,
we
introduce
microneedles
composed
of
silk
fibroin
hydrogel
loaded
deferoxamine
(SF+MNs+DFO)
inhibit
ferroptosis.
SF+MNs+DFO
exhibits
optimal
mechanical
properties
drug
release
kinetics.
Histopathological
shows
reduced
inflammation,
collagen
deposition
RSI
treated
SF+MNs+DFO,
leading
accelerated
tissue
regeneration
decreased
scarring.
Molecular
biology
studies
indicate
that
inhibits
by
reducing
concentration
free
Fe2+
body,
thereby
decreasing
generation
reactive
oxygen
species
(ROS)
lipid
peroxidation.
Immunofluorescence
further
confirm
neovascularization
fibrosis
SF+MNs+DFO-treated
RSI,
indicating
enhanced
repair.
not
only
but
also
promotes
angiogenesis
regeneration,
offering
promising
therapeutic
strategy
for
RSI.
conclusion,
DFO-loaded
SF
provide
precise
delivery,
iron
chelation,
improved
healing,
demonstrating
an
effective
approach
treating
